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| 1 | Electroporative interleukin-10 gene transfer ameliorates carbon tetrachlo-ride-induced murine liver fibrosis by MMP and TIMP modulation显示文摘瞄准:肝纤维变性代表响应长期的肝损伤愈合并且结疤的一个过程。为肝纤维变性的有效治疗正在缺乏。Interleukin-10 (IL-10 ) 是 cytokine 下面调整支持 inflammatory 回答并且在肝的纤维发生上有调节效果。这研究的目的是调查 electroporative IL-10 基因治疗是否在老鼠上有肝的 fibrolytic 效果。方法:肝的纤维变性被在老鼠管理四氯化碳(CCl4 ) 10 个星期导致。在肝的纤维变性被建立以后,人的 IL-10 表示原生质标志经由 electroporation 被交付。组织病理学说,反向的抄写聚合酶链反应(RT-PCR ) ,弄污的免疫,和明胶 zymography 被用来调查 IL-10 的行动的可能的机制。结果:人的 IL-10 基因治疗在老鼠颠倒了导致 CCl4 的肝纤维变性。RT-PCR 表明那 IL-10 基因治疗稀释了肝 TGF-beta1,骨胶原 alpha1, fibronectin,和房间粘附分子在规定上面的 mRNA。后面的基因转移,两个都, alpha 光滑的肌肉肌动朊和 cyclooxygenase-2 的激活显著地被稀释。而且, IL-10 显著地禁止了矩阵 metalloproteinase-2 (MMP-2 ) 和矩阵 metalloproteinase (TIMP ) 的织物禁止者在 CCl4 沉醉以后的激活。结论:我们证明那 IL-10 基因治疗在老鼠稀释了导致 CCl4 的肝纤维变性。在调整 fibrogenic 和支持 inflammatory 基因回答上面阻止的 IL-10。它的溶胶原效果可以被归因于 MMP 和 TIMP 调整。IL-10 基因治疗可以是对有潜在的临床的使用的肝纤维变性的一种有效治疗学的形式。 | Wen-ying CHOU Cheng-nan LU Tsung-hsing LEE Chia-ling WU Kung-sheng HUNG Allan M CONCEJERO Bruno JAWAN Cheng-haung WANG | 2006 | Acta Pharmacologica Sinica2006，27，4： | 25 |
| 2 | Interventional radiology in living donor liver transplant显示文摘The shortage of deceased donor liver grafts led to the use of living donor liver transplant(LDLT).Patients who un-dergo LDLT have a higher risk of complications than those who undergo deceased donor liver transplantation(LT).Interventional radiology has acquired a key role in every LT program by treating the majority of vascular and nonvascular post-transplant complications,improving graft and patient survival and avoiding,in the majority of cases,surgical revision and/or re-transplant.The aim of this paper is to review indications,diagnostic modalities,technical considerations,achievements and potential complications of interventional radiology procedures after LDLT. | Yu-Fan Cheng Hsin-You Ou Chun-Yen Yu Leo Leung-Chit Tsang Tung-Liang Huang Tai-Yi Chen Hsien-Wen Hsu Allan M Concerjero Chih-Chi Wang Shih-Ho Wang Tsan-Shiun Lin Yueh-Wei Liu Chee-Chien Yong Yu-Hung Lin Chih-Che Lin King-Wah Chiu Bruno Jawan Hock-Liew Eng Chao-Long Chen | 2014 | World Journal of Gastroenterology2014，20，20： | 5 |
| 3 | Living donor liver transplantation with body-weight more or less than 10 kilograms显示文摘AIM: To compare the outcomes of pediatric patients weighing less than or more than 10 kg who underwent liver transplantation.METHODS: Data for 196 pediatric patients who underwent living donor liver transplantation between June 1994 and February 2011 were reviewed retrospectively.The information for each patient was anonymized and de-identified before analysis. The data included information regarding the pre-transplant conditions, intraoperative fluid replacement and outcomes for each patient. The 196 patients were divided into two groups: those with body weights of less than 10 kg were included in group 1(G1; n =101), while those with body weights of more than 10 kg were included in group 2(G2; n = 95). For each group, the patients' ages, body weights, heights,pediatric end stage liver disease scores, anesthesia times, and warm and cold ischemic times were analyzed. In addition, between-group comparisons were also made. Mann-Whitney U tests were used to compare all the variables except for complications and survival rates, which were analyzed using χ 2 tests and Kaplan-Meier tests, respectively.RESULTS: The general medical conditions of the G1patients were worse than those of the G2 patients, as shown by the higher pediatric end stage liver disease scores and poorer Z-scores. In addition, the preoperative Hb and serum albumin levels were all lower for the G1 patients than for the G2 patients. The G1 patients also had significantly more intraoperative blood loss than the G2 patients. In addition, the intraoperative fluid requirements for the G1 patients,including leukocyte poor red blood cell transfusions,5% albumin infusions and crystalloid infusions, were significantly higher than those for the G2 patients. The risk of intraoperative portal vein thrombosis was higher for the patients in G1 than for those in G2. However,the one-year survival rates(95.9% and 96.8% for G1 and G2, respectively) and three-year survival rates(94.9% and 94.6% for G1 and G2, respectively) for both groups were similar.CONCLUSION: Patients weighing less than 10 kg typically have poorer conditions, but their survival rates are comparable to those of children weighing more than 10 kg. | Sheng-Chun Yang Chia-Jung Huang Chao-Long Chen Chih-Hsien Wang Shao-Chun Wu Tsung-Hsiao Shih Sin-Ei Juang Ying-En Lee Bruno Jawan Yu-Feng Cheng Kwok-Wai Cheng | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 4 | SINGLE IMAGING MODALITY EVALUATION OF LIVING DONORS IN LIVER TRANSPLANTATION: MAGNETIC RESONANCE IMAGING1显示文摘 | Yu Fan Cheng Chao Long Chen Tung Liang Huang Tai Yi Chen Tze Yu Lee Yaw Sen Chen Chih Chi Wang Vanessa de Villa Shigeru Goto Yuan Cheng Chiang Hock Liew Eng Bruno Jawan Hak Kim Cheung | 2001 | Transplantation2001，，9： | 1 |
| 5 | Stress Response to Hepatectomy in Patients with a Healthy or a Diseased Liver显示文摘 | Albert Kuo-Mao Lan M.D. Hsiang-Ning Luk M.D. Ph.D. Shigeru Goto M.D. Ph.D. Shyr-Ming Sheen Chen M.D. Hock-Liew Eng M.D. Yaw-Sen Chen M.D. Vanessa H. Villa M.D. Ph.D. Chih Chi Wang M.D. Yu-Fen Cheng M.D. Chao-Long Chen M.D. Ju-Hao Lee M.D. Bruno Jawan M | 2003 | World Journal of Surgery2003，，7： | 1 |
| 6 | Interventional radiologic procedures in liver transplantation显示文摘 | Yu Fan Cheng Yaw Sen Chen Tung Liang Huang Vanessa de Villa Tai Yi Chen Tze Yu Lee Chih Chi Wang Yuan Cheng Chiang Hock Liew Eng Hak Kim Cheung Bruno Jawan Shih Hor Wang Shigeru Goto Chao Long Chen | 2001 | Transplant International2001，，4： | 1 |
| 7 | Dextrose in the banked blood products does not seem to affect the blood glucose levels in patients undergoing liver transplantation显示文摘AIM: Hyperglycemia commonly seen in liver transplantation (LT) has often been attributed to the dextrose in the storage solution of blood transfusion products. The purpose of the study is to compare the changes of the blood glucose levels in transfused and non-transfused patients during LT. METHODS: A retrospective study on 60 biliary pediatric patients and 16 adult patients undergoing LT was carried out. Transfused pediatric patients were included in Group Ⅰ (GI), those not transfused in Group Ⅱ (GⅡ). Twelve adult patients were not given transfusion and assigned to Group Ⅲ (GⅢ); whereas, four adult patients who received massive transfusion were assigned to Group Ⅳ (GⅣ). The blood glucose levels, volume of blood transfused, and the volume of crystalloid infused were recorded, compared and analyzed. RESULTS: Results showed that the changes in bloodglucose levels during LT for both non-transfused and minimally transfused pediatric groups and non-transfused and massively-transfused adult groups were almost the same. CONCLUSION: We conclude that blood transfusion does not cause significant changes in the blood glucose levels inthis study. | Kwok-Wai Cheng Chia-Chih Tseng Chih-Hsien Wang Yaw-Sen Chen Chih-Chi Wang Tung-Liang Huang Hock-Liew Eng King-Wah Chiu Shih-Hor Wang Chih-Che Lin Tsan-Shiun Lin Yueh-Wei Liu Bruno Jawan | 2005 | World Journal of Gastroenterology2005，11，18： | 1 |
| 8 | Human Opioid Receptor A118G Polymorphism Affects Intravenous Patient-controlled Analgesia Morphine Consumption after Total Abdominal Hysterectomy显示文摘 | Wen-Ying Chou Cheng-Haung Wang Ping-Hsin Liu Chien-Cheng Liu Chia-Chih Tseng Bruno Jawan | 2006 | Anesthesiology2006，，2： | 1 |
| 9 | Intra‐operative management of low portal vein flow in pediatric living donor liver transplantation显示文摘 | Ting‐Lung Lin Li‐Wei Chiang Chao‐Long Chen Shih‐Hor Wang Chih‐Che Lin Yueh‐Wei Liu Chee‐Chien Yong Tsan‐Shiun Lin Wei‐Feng Li Bruno Jawan Yu‐Fan Cheng Tai‐Yi Chen Allan M. Concejero Chih‐Chi Wang | 2012 | Transplant International2012，，5： | 1 |
| 10 | Outcomes of long storage times for cryopreserved vascular grafts in outflow reconstruction in living donor liver transplantation显示文摘 | Chih‐Chi Wang Salvador Lopez‐Valdes Ting‐Lung Lin Anthony Yap Chee‐Chien Yong Wei‐Feng Li Shih‐Ho Wang Chih‐Che Lin Yueh‐Wei Liu Tsan‐Shiun Lin Allan M. Concejero Hock‐Liew Eng Douglas Henry Yu‐Fan Cheng Bruno Jawan Chao‐Long Chen | 2014 | Liver Transpl2014，，2： | 1 |
| 11 | Major Hepatectomy in Children: Approaching Blood Transfusion-free显示文摘 | Chih-Che Lin MD Chao-Long Chen MD Yu-Fan Cheng MD King-Wah Chiu MD Bruno Jawan MD Chih-Cheng Hsaio MD | 2006 | World Journal of Surgery2006，，6： | 1 |
| 12 | Effect of autologous blood donation on the central venous pressure, blood loss and blood transfusion during living donor left hepatectomy显示文摘AIM: Autologous blood donation (ABD) is mainly used to reduce the use of banked blood. In fact, ABD can be regarded as acute blood loss. Would ABD 2-3 d before operation affect the CVP level and subsequently result in less blood loss during liver resection was to be determined.METHODS: Eighty-four patients undergoing living donor left hepatectomy were retrospectively divided as group Ⅰ (GⅠ)and group Ⅱ (GⅡ) according to have donated 250-300 mL blood 2-3 d before living donor hepatectomy or not. The changes of the intraoperative CVP, surgical blood loss,blood products used and the changes of perioperative hemoglobin (Hb) between groups were analyzed and compared by using Mann-Whitney Utest.RESULTS: The results show that the intraoperative CVP changes between GⅠ (n = 35) and GⅡ (n = 49) up to graft procurement were the same, subsequently the blood loss,but ABD resulted in significantly lower perioperative Hb levels in GⅠ.CONCLUSION: Since none of the patients required any blood products perioperatively, all the predonated bloods were discarded after the patients were discharged from the hospital, It indicates that ABD in current series had no any beneficial effects, in term of cost, lowering the CVP, blood loss and reduce the use of banked blood products, but resulted in significant lower Hb in perioperative period. | Bruno Jawan Yu-Fan Cheng Chia-Chi Tseng Yaw-Sen Chen Chih-Chi Wang Tung-Liang Huang Hock-Liew Eng Po-Ping Liu King-Wah Chiu Shih-Hor Wang Chih-Che Lin Tsan-Shiun Lin Yueh-Wei Liu Chao-Long Chen | 2005 | World Journal of Gastroenterology2005，11，27： | 0 |
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