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354篇 您的检索式:作者名="Bruining H"
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1Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed.Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals 2021World Journal of Gastroenterology2021,27,25:4
2Antibody phage display technology and its application 显示文摘Hoogenboom H R de Bruine A P Hufton S E 1998Immunotechnology1998,4,:2
3Prevention of lactic acidosis due to metform in intox ication in contrastmedia nephropathy显示文摘Landewe-Cleuren S van Zwam W H de Bruin T W 2000NedTudschr Geneeskd2000,144,40:1
4Psychiatric characteristics in a self-selected sample of boys with Klinefeher syndrome 显示文摘Bruining H Swaab H Kas M 2009Pediatrics2009,123,5:1
5Enhancement of gas-liquid mass transfer by a dispersed second liquid phase显示文摘Bruining W J Joosten G E H Beenackers A A C M 1986Chem Eng Sci1986,41,7:1
6Hemiplegic gait : analysis of temporal variables显示文摘Brandstater ME de Bruin H Gowland C 1983Arch Phys Med Rehabil1983,64,:1
7Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia显示文摘BRUINS P TE VELTHUIS H YAZDANBAKHSH A P 1997Circulation1997,96,:1
8Activation of the complement system during and after eardiopulmonary bypass surgery: postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia显示文摘BRUINS P TE VELTHUIS H YAZDANBAKHSH A P 1997Circul tion1997,96,:1
9Activation of the complement system during and after cardioputmonary bypass surgery:pestsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia显示文摘Bruins P Te Velthuis H Yazdanbakhsh AP 1997Circulation1997,96,:1
10Wild Cantor attractors exist显示文摘 Keller G Nowicki T 1996Annals of Mathematics1996,143,1:1
11Activation of thecomplement system during and after cardiopulmonary bypass surgery:post-surgery activation involves C-reactive protein and is associatedwith post operative arrhythmia显示文摘Bruins P Velthuis H Yazdanbakhsh AP 1997Circulation1997,96,10:1
12Genome scanfor blood pressure in Dutch dyslipidemic families reveals linkage to alocus on chromosome 4p显示文摘Allayee H de Bruin TW Michelle Dominguez K 2001Hypertension2001,38,4:1
13The scintillation method tested over a dry vineyard area显示文摘De Bruin H A R Van Den Hurk B J J M Koshiek W 1995Boundary-Layer Meteorology1995,76,:1
14Sensors and Actuators显示文摘Allen H V Terry S C De Bruin D W 198920:153-1611989,20,:1
15Activation of the complement system during and after cardiopulmonary bypass surgery: postsurgery activation involves C - reactive protein and is associated with postoperative arrhythmia 显示文摘Bruins P te-Velthuis H Yazdan AP 1997Circulaction1997,96,10:1
16Re- sources access needs and capabilities as mediators of the re- lationship between VC firm size and syndication显示文摘VERWAAL E BRUINING H WRIGHT M 2010Small Business Economics2010,34,3:1
17Hemiplegic gait:analysis of temporal variables显示文摘Brandstater ME de Bruin H Gowland C 1983Arch Phys Med Rehabil1983,64,12:1
18Activation of the complement system during and after cardiopulmonary bypass surgery:postsurgery activation involves C-reactive protein and is associated with postoperative arrhythmia显示文摘 Velthuis H Yazdanbakhsh AP 1997Circulation1997,96,10:1
19Restoration of wet dune sla- cks on the Dutch Wadden Sea islands : Recolonization after large- scale sod cutting显示文摘Grootjans AP Everts H Bruin K 2001Restoration Ecology2001,9,2:1
20Food Security in China and Contingency Planning: the Significance of Grain Reserves 显示文摘Bruins H J Bu F 2006Journal of Contingencies & Crisis Management2006,,3:1
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