|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | The lithium intercalation compound Li2CoSiO4 and its behaviour as a positive electrode for lithium batteries 显示文摘 | NESS C DELOBEL B ARMSTRONG A R BRUCE P G | 2007 | Chem Commun (Camb)2007，46，： | 1 |
| 3 | Selection and characterization of β-lactam-β-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 β-lactamase gene显示文摘 | Sergei B V Bruce G Lakshmi P K | 1998 | Antimicrob Agents Chemother1998，42，： | 1 |
| 4 | Study of the mechanism for poly (p-phenylene) benzoxazole polymerization-A remarkable reaction pathway to make rigid-rod polymers显示文摘 | Ying H S Jerry P H Bruce B | 1998 | Macromolecules1998，31，： | 1 |
| 5 | 查看详情显示文摘 | H L Nguyen P N Horton M B Hursthouse C Legon D W Bruce | | 0，，： | 1 |
| 6 | DNA extraction from several cacti显示文摘 | Candelario M J Natalia D Bruce P B | 2000 | Hort Science2000，35，6： | 1 |
| 7 | Analysis of alkylphenol ethoxylate metabolites in the aquatic environment using liquid chromatography - electrospray spectrometry 显示文摘 | Ferguson P L Charles R I Bruce J B | 2000 | Analytical Chemistry2000，72，18： | 1 |
| 8 | The Presentation of CEOs in the Press,1990-2000:Increasing Salience,Positive Valence,and a Focus onCompetency and Personal Dimensions of Image显示文摘 | Dong-Jin P Bruce K B | 2004 | Journal ofPublic Relations Research2004，16，1： | 1 |
| 9 | Nanostructured materials for advanced energy conversion and storage devices显示文摘 | ARICO A S BRUCE P SCROSATI B | | 0，，04： | 1 |
| 10 | Group interentions for the prevenion of inju-ries in young children, a systematic review 显示文摘 | Bruce B McGrath P | 2005 | Injury Preven-tion2005，11，： | 1 |
| 11 | Nanomaterials for rechargeable lithium batteries显示文摘 | Bruce P G Scrosati B Tarascon J M | 2008 | Angewandte Chemie:International Edition2008，47，16： | 1 |
| 12 | Nanomaterials for rechargeable lithimn batteries 显示文摘 | Bruce P G Scrosati B Tarascon J M | 2008 | Angcwandte Chemie International Edition2008，47，： | 1 |
| 13 | Effects of broodstock dietary lipid on fatty acid compositions of eggs from sea bass ( Dicentrarchus labrax )显示文摘 | Farndale B M Bruce M P | 1997 | Aquaculture1997，149，： | 1 |
| 14 | Atypical idiopathic intracranial hypertension:normal BMI and older patients显示文摘 | Bruce B B Kedar S Van Stavern G P | | 0，，22： | 1 |
| 15 | Significance of dysregulated metadherin and microRNA-375 in head and neck cancer显示文摘 | HUI A B BRUCE J P ALAJEZ N M | | 0，，24： | 1 |
| 16 | Nanomaterials for rechargeable lithium batteries显示文摘 | BRUCE P G SCROSATI B TARASCON J M | 2008 | Angew Chem Int Ed2008，47，： | 1 |
| 17 | Cis-acting elements involved in photoregulation of an oat phytochrome promoter in rice显示文摘 | BRUCE W B QUAIL P H | 1990 | Plan Cell1990，，2： | 1 |
| 18 | Nanomate rials for rechargeable lithium batteries显示文摘 | BRUCE P G SCROSATI B TARASCON J M | 2008 | Angewandte Chemie-International Edition2008，47，： | 1 |
| 19 | Nanomaterials for rechargeable lithium batteries显示文摘 | BRUCE P G SCROSATI B TARASCON J M | 2008 | Angewandte Chemle Interna- tional Edition2008，47，16： | 1 |
| 20 | Nanomaterials for rechargeable lithium batteries 显示文摘 | BRUCE P G SCROSATI B TARASCON J M | 2008 | Angewandte Chemie International Edition2008，，16： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员