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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Risk factors for coronary heart disease in women with systemic lupus erythematosus: the Toronto Risk Factor Study显示文摘 | Bruce IN Urowitz MB Gladman DD | 2003 | Arthritis Rheum2003，48，11： | 1 |
| 3 | Natural history of hypercholester- olemia in systemic lupus erythematosus显示文摘 | Bruce IN Urowitz MB Gladman DD | 1999 | J Rheumatol1999，26，11： | 1 |
| 4 | A 10-year follow-up of the outcome of lumbar microdiscectomy 显示文摘 | Gordon F Bruce I Sele MB | 1998 | Spine1998，23，10： | 1 |
| 5 | Intrathecal baclofen formanagement of spastic cerebral palsy:multicenter trial显示文摘 | Gilmartin R Bruce D Storrs B MB | 2000 | J Child Neurol2000，15，3： | 1 |
| 6 | A 10 -year follow -up of tile outcome of lumbar microdsicectomy 显示文摘 | Gordon F Bruce I Sele MB | 1998 | Spine1998，23，： | 1 |
| 7 | A 10-year follow-up of the outcome of lumbar microdsicectomy显示文摘 | Gordon F Bruce I Sele MB | 1998 | Spine1998，23，10： | 1 |
| 8 | Risk factors for coronary heart disease in women with systemic lupus erythematosus: the Toronto risk factor study 显示文摘 | Bruce IN Urowitz MB Gladman DD | 2003 | Arthritis Rheum2003，48，： | 1 |
| 9 | Does the Extent of Operation Influence the Prognosis in Patients With Melanoma Metastatic to Inguinal Nodes?显示文摘 | G. Bruce Mann MB BS PhD FRACS Daniel G. Coit MD | 1999 | Annals of Surgical Oncology1999，，3： | 1 |
| 10 | Natural history of hypercholesterolemia in SLE显示文摘 | Bruce IN Urowitz MB Gladman BD Hallett DC | 1999 | J-Rheumatol1999，26，10： | 1 |
| 11 | Premature atherosclerosis in systemic lupus erythematosus显示文摘 | Bruce IN Gladman DD Urowitz MB | 2000 | Rheum Dis Clin North Am2000，26，2： | 1 |
| 12 | Contribution of traditional risk factors to coronary atery disease in patients with SLE显示文摘 | Rahman P Urowitz MB Gladman BD Bruce IN | 1999 | J-Rheumatol1999，26，： | 1 |
| 13 | Risk factors for cornary heart disease in women with systemic lupus erythernatosus: the Toronto Risk Factor Study 显示文摘 | Bruce IN Urowitz MB Gladman DD | 2003 | Anhritis Rheum2003，48，11： | 1 |
| 14 | Detection and modification of risk factors for coronary artery disease in patients with systemic lupus erythematosus, a quality improvement study 显示文摘 | Bruce IN Gladman DD Urowitz MB | 1998 | Clin Exp Rheumatol1998，16，： | 1 |
| 15 | Effect of cancer screening and desirable health behaviors on functional status, self - rated health, health service use and mortality显示文摘 | Gerda GF Bruce MB Maragatha NK | 2007 | JAGS2007，55，： | 1 |
| 16 | A 10 - year follow-up of the out- come of lumbar microdsicectomy显示文摘 | Gordon F Bruce I Sele MB | 1998 | Spine1998，23，： | 1 |
| 17 | Risk factors for coronary heart disease in women with systemic lupus erythematosus 显示文摘 | Bruce IN Urowitz MB Gladdman DD | 2003 | Arthritis Rheum2003，48，： | 1 |
| 18 | Interactions among toxins that inhibit N-type and P-type calcium channels显示文摘 | Stefan 1M Linda MB Bruce PB | | J Gem Physlol0，119，： | 1 |
| 19 | Prolonged remission in systemic lupus erythematosus 显示文摘 | Urowitz MB Feletar M Bruce IN | 2005 | J Rheumatol2005，32，8： | 1 |
| 20 | 单剂量丙泊酚注射对慢性每日头痛患者疼痛和生活质量的影响:一项随机双盲对照试验显示文摘背景有少量的病例研究提倡静脉输注丙泊酚来治疗慢性每日头痛(chronicdailyheadache;CDH),然而,尚无该疗法的随机对照试验。在本随机双盲对照试验中,我们的目的是观察单剂量的静脉丙泊酚输注(2.4mg&g)能否显著降低CDH患者临床不适及接下来30天的疼痛。方法符合标准的CDH成人患者,分别静脉输注丙泊酚(n=20)或安慰剂咪达唑仑(n=20)对照组。主要的结果评估包括:①治疗30天后头痛失劳动力调查评分(HeadacheDisabilityInventory;HDI);②头痛指数(HeadacheIndex,HI),治疗期间30天的头痛强度总评估;③采用用药量化评分表(MedicationQuantificationScale,第1II版)评估镇痛药消耗量。结果输注丙泊酚30天后,HDI降低了9.47点(标准差14.1)(P=0.009),但是其降低程度比认为头痛相关失劳动力调查指数(HDI)有临床意义的降低程度更小。与对照组相比,HDI无显著统计差异。在降低平均头痛强度(用头痛指数评估)或用药量化表(MedicationQuantification Scale)(第111版)方便,组内及两组间无统计学差异。结论单剂量的丙泊酚静脉输注(2.4mg/kg)产生了有统计学意义的变化,但是在输注药物后30天CDH失劳动力方面的改变无临床意义。丙泊酚也不能减轻头痛强度和减少镇痛药的应用。本研究不支持静脉输注丙泊酚临床治疗CDH。 | Mark K. Simmonds, MB ChB Saifudin Rashiq, BM BS Igor A. Sobolev, MD Bruce D. Dick, PhD Daniel P. Gray, MD Bradley J. Stewart, MD Kathryn I. Jamieson-Lega, BSc 苏海华(译) | 2011 | 麻醉与镇痛2011，7，5： | 0 |
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