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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes: Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism 显示文摘 | Bruce CR Carey AL Hawley JA | 2003 | Diabetes2003，52，9： | 1 |
| 3 | Type 2 fractures of the distal clavicle: 1 new surgical technique显示文摘 | Goldberg JA Bruce WJ Sormabend DH | 1997 | J Shoulder Elbow Surg1997，6，4： | 1 |
| 4 | Mechanism of Actin Polymerization in Cellular ATP Depletion显示文摘 | Simon JA Melanie AH Bruce AM | 2003 | JBC2003，11，： | 1 |
| 5 | New methods for the evaluation and treatment of craniofacial dysostosis-associated cerebellar tonsillar herniation显示文摘 | Fearon JA Swift DM Bruce DA | 2001 | Plast Reconstr Surg2001，108，7： | 1 |
| 6 | Production and regeneration of Lactobacillus casei protoplasts显示文摘 | Lyang Ja Lee Wicknep Bruce M Chassy | 1984 | Appl Environ Microbiol1984，48，： | 1 |
| 7 | Depression in homeboundolder adults : recent advances in screening and psychoso-cial interventions显示文摘 | Choi NG Sirey JA Bruce ML | 2013 | Curr Trans 1 Geriatr Exp GerontolRep2013，2，1： | 1 |
| 8 | Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes:evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism显示文摘 | Bruce CR Carey AL Hawley JA | 2003 | Diabetes2003，52，9： | 1 |
| 9 | Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes:evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism显示文摘 | Bruce CR Carey AL Hawley JA | | 0，，： | 1 |
| 10 | Bilateral changes in foveal structure in individuals with amblyopia 显示文摘 | Bruce A Pacey IE Bradbury JA | 2013 | Ophthalmology2013，120，2： | 1 |
| 11 | Risk factors for idiopathic intracranial hypertension in men:a casecontrol study显示文摘 | Fraser JA Bruce BB Rucker J | 2010 | J Neurol Sci2010，290，： | 1 |
| 12 | Perceived stigma as a predictor of treatment discontinuation in young and older outpatients with depression显示文摘 | Sirey JA Bruce ML Alexopoulos G S | 2001 | Am J Psychiatry2001，158，： | 1 |
| 13 | Time-dependent changes inmyocardial structure following discrete injury in mice deficient of matrix metal-loproteinase-3显示文摘 | Mukherjee R Bruce JA McClister DM | 2005 | J Mol Cell Cardiol2005，39，2： | 1 |
| 14 | Medico-legal aspects of using tissueplasminogen activator in acute ischemic stroke显示文摘 | Bruce NT Neil WP Zivin JA | 2011 | Cerebrovasc Disand Stroke2011，13，3： | 1 |
| 15 | Prolonged deterioration of ischemic brain energy metabolism and acidosis associated with hyperglycemia: humancerebral infarction studied by serial 31P NMR spectroscopy显示文摘 | Levine SR Welch KM Helpern JA Chopp M Bruce R Selwa J | 1988 | Ann Neurol1988，23，4： | 1 |
| 16 | Risk factors for idiopathic intracranial hypertension in men: a case-control study显示文摘 | Fraser JA Bruce BB Rucker J | 2010 | J Neurol Sci2010，290，12： | 1 |
| 17 | Stigma as a barrier to recovery : Perceived stigma and patient-rated severity of illness as predictors of antidepressant drug adherence显示文摘 | Sirey JA Bruce ML Alexopoulos GS | 2001 | Psychiatric Serv- ices2001，52，12： | 1 |
| 18 | Response of oral lichen planus to topical tacrolimus in 37 patients显示文摘 | Byrd JA Davis MD Bruce A J | 2004 | Arch Dermatol2004，140，： | 1 |
| 19 | Response of oral li-chen planus to topical tacrolimus in 37 patients显示文摘 | Byrd JA Davis MD Bruce AJ | 2004 | ArchDermatol2004，140，12： | 1 |
| 20 | Medico-legal aspects of using tissue plasminogen activator in acute ischemic stroke 显示文摘 | Bruce NT Neil WP Zivin JA | 2011 | Curr Treat Options Cardiovasc Med2011，13，3： | 1 |
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