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| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Network applications of Bloom Filters : asurvey显示文摘 | Broder A Mitzenmacher M | 2004 | Internet Mathematics2004，1，4： | 1 |
| 3 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 4 | Min-wise independent permutations 显示文摘 | Broder A Z Charikar M Frieze A M | 2000 | Journal of Computer and System Sciences2000，60，3： | 1 |
| 5 | Summary cache: a scalable wide-area Web cache sharing protocol显示文摘 | FAN L CAO P ALMEIDA J BRODER A Z | 2000 | IEEE-ACM Trans on Networking2000，8，3： | 1 |
| 6 | Inhibition of the TWEAK/ Fnl4 pathway attenuates renal disease in nephrotoxic serum ne- phritis显示文摘 | Xia Y Campbell SR Broder A | 2012 | Clin Immunol2012，145，2： | 1 |
| 7 | Summary cache : A scalable wide--area web cache sharing protocol显示文摘 | Fan Li Cao P Almeida J and Broder A | 2000 | IEEE/ A CM Transactions on Networking2000，8，3： | 1 |
| 8 | A theoretical and empirical exegesis of the consumer involvement construct: The psychology of the food shopper显示文摘 | Broderic A Mueller R | 1999 | Journal of Marketing Theory and Practice1999，7，4： | 1 |
| 9 | Graph structure in the Web 显示文摘 | BRODER A KUMAR R MAGHOUL F | 2000 | Computer Networks2000，33，6： | 1 |
| 10 | Syntactic clustering of the web 显示文摘 | Broder A Z Glassman S C Manasse M S | 1997 | Computer Networks and ISDN Systems1997，29，8： | 1 |
| 11 | Graph Structure In The Web显示文摘 | Broder A Kumar R Maghoul | | 0，，01： | 1 |
| 12 | A taxonomy of web search 显示文摘 | Broder A | 2002 | SIGIR Forum2002，36，2： | 1 |
| 13 | Graph structure in the web显示文摘 | Broder A Kumar R Maghoul F Raghavan P Rajagopalan S Stata R Tomkins A Wiener J | 2000 | Computer Networks2000，33，： | 1 |
| 14 | Graph strueture in the web 显示文摘 | A Broder | 2000 | Computer net- works2000，33，1： | 1 |
| 15 | Network applications of Bloom filters: a survey显示文摘 | Broder A Mitzenmacher M | 2002 | Internet Mathematics2002，1，4： | 1 |
| 16 | A taxonomy of web search显示文摘 | Broder A | 2002 | ACM Sigir Forum2002，36，2： | 1 |
| 17 | Graph structure in the web显示文摘 | Broder A Kumar R Maghoul F | 2000 | Compute Networks2000，33，123456： | 1 |
| 18 | Graph structure in the Web 显示文摘 | Broder A Kumar Maghoul F Raghavan P Rajagopalan S Stata R Tomkins A WienerJ | 2000 | Computer Networks2000，33，： | 1 |
| 19 | Graph Structure in the Web显示文摘 | Broder A Kumar R Maghoul F | 2000 | Computer Networks2000，33，16： | 1 |
| 20 | Hydroxychloroquine use is associated with lower odds of persistently positive antiphospholipid antibodies and/or lupus anticoagulant in systemic lupus erythematosus显示文摘 | Broder A Putterman C | 2013 | J Rheumatol2013，40，1： | 1 |
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