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| 1 | Expression of infection-related genes in parasites and host during murine experimental infection with Leishmania ( Leishmania ) 显示文摘 | Pereira B A Britto C Alves C R | 2012 | Microbial Pathogenesis2012，52，2： | 1 |
| 2 | Simultaneous follow-up of mouse colon lesions by colonoscopy and endoluminal ultrasound biomicroscopy显示文摘AIM:To evaluate the potential use of colonoscopy and endoluminal ultrasonic biomicroscopy(eUBM)to track the progression of mouse colonic lesions.METHODS:Ten mice were treated with a single azoxy-methane intraperitoneal injection(week 1)followed by seven days of a dextran sulfate sodium treatment in their drinking water(week 2)to induce inflammationassociated colon tumors.eUBM was performed simultaneously with colonoscopy at weeks 13,17-20 and21.A 3.6-F diameter 40 MHz mini-probe catheter was used for eUBM imaging.The ultrasound mini-probe catheter was inserted into the accessory channel of a pediatric flexible bronchofiberscope,allowing simultaneous acquisition of colonoscopic and eUBM images.During image acquisition,the mice were anesthetized with isoflurane and kept in a supine position over a stainless steel heated surgical waterbed at 37℃.Both eUBM and colonoscopic images were captured and stored when a lesion was detected by colonoscopy or when the eUBM image revealed a modified colon wall anatomy.During the procedure,the colon was irrigated with water that was injected through a flush port on the mini-probe catheter and that acted as the ultrasound coupling medium between the transducer and the colon wall.Once the acquisition of the last eUBM/colonoscopy section for each animal was completed,the colons were fixed,paraffin-embedded,and stained with hematoxylin and eosin.Colon images acquired at the first time-point for each mouse were compared with subsequent eUBM/colonoscopic images of the same sites obtained in the following acquisitions to evaluate lesion progression.RESULTS:All 10 mice had eUBM and colonoscopic images acquired at week 13(the first time-point).Two animals died immediately after the first imaging acquisition and,consequently,only 8 mice were subjected to the second eUBM/colonoscopy imaging acquisition(at the second time-point).Due to the advanced stage of colonic tumorigenesis,5 animals died after the second time-point image acquisition,and thus,only three were subjected to the third eUBM/colonoscopy imaging acquisition(the third time-point).eUBM was able to detect the four layers in healthy segments of colon:the mucosa(the first hyperechoic layer moving away from the mini-probe axis),followed by the muscularis mucosae(hypoechoic),the submucosa(the second hyperechoic layer)and the muscularis externa(the second hypoechoic layer).Hypoechoic regions between the mucosa and the muscularis externa layers represented lymphoid infiltrates,as confirmed by the corresponding histological images.Pedunculated tumors were represented by hyperechoic masses in the mucosa layer.Among the lesions that decreased in size between the first and third time-points,one of the lesions changed from a mucosal hyperplasia with ulceration at the top to a mucosal hyperplasia with lymphoid infiltrate and,finally,to small signs of mucosal hyperplasia and lymphoid infiltrate.In this case,while lesion regression and modification were observable in the eUBM images,colonoscopy was only able to detect the lesion at the first and second time-points,without the capacity to demonstrate the presence of lymphoid infiltrate.Regarding the lesions that increased in size,one of them started as a small elevation in the mucosa layer and progressed to a pedunculated tumor.In this case,while eUBM imaging revealed the lesion at the first time-point,colonoscopy was only able to detect it at the second time-point.All colonic lesions(tumors,lymphoid infiltrate and mucosal thickening)were identified by eUBM,while colonoscopy identified just76%of them.Colonoscopy identified all of the colonic tumors but failed to diagnose lymphoid infiltrates and increased mucosal thickness and failed to differentiate lymphoid infiltrates from small adenomas.During the observation period,most of the lesions(approximately67%)increased in size,approximately 14%remained unchanged,and 19%regressed.CONCLUSION:Combining eUBM with colonoscopy improves the diagnosis and the follow-up of mouse colonic lesions,adding transmural assessment of the bowel wall. | Rossana C Soletti Kelly Z Alves Marcelo AP de Britto Dyanna G de Matos Mnica Soldan Helena L Borges Joo C Machado | 2013 | World Journal of Gastroenterology2013，19，44： | 1 |
| 3 | Efficacy of chest CT in a pediatric ICU:a prospective study显示文摘 | Thomas K E Owens C M Britto J | 2000 | Chest2000，117，6： | 1 |
| 4 | Advanced Oxidation Process of Phenolic Compounds in Industrial Wasterwater 显示文摘 | Britto J M Rangel M C | 2008 | Quim Nova2008，31，： | 1 |
| 5 | Down-regulation of ABCBI transporter by atorvastation in a human hepatoma cell line and in human peripheral blood mononuclear cells显示文摘 | RODRIGUES A C CURI R BRITTO L R | 2006 | Biochim Biophys Acta2006，1760，12： | 1 |
| 6 | NADPH Oxidase and the degeneration of dopaminergic neurons in parkinsonian mice显示文摘 | HERNANDES M S CAFE-MENDES C C BRITTO L R | 2013 | Oxid Med Cell Longev2013，2013，15： | 1 |
| 7 | NADPH oxidaseand the degeneration of dopaminergic neurons in parkinsonian mice显示文摘 | Hemandes M S Caf6-Mendes C C Britto L R | 2013 | Oxid Med Cell Longev2013，2013，15： | 1 |
| 8 | A methodology for unveiling global innovation networks: Patent citations as clues to cross border knowledge flows显示文摘 | Ribeiro L C Kruss G Britto G | 2014 | Scientometrics2014，101，1： | 1 |
| 9 | Cloning and daily expression of the timeless gene in Aedes aegypti (Diptera: Culicidae)显示文摘 | Gentile C Meireles-Filho AC Britto C | 2006 | Insect Biochem Mol Biol2006，36，11： | 1 |
| 10 | Paleoparasitology of Chagas disease revealed by infected tissues from Chilean mum-mies显示文摘 | Ferreira LF Britto C Cardoso MA | 2000 | Acta Trop2000，75，： | 1 |
| 11 | Numerical and centrifuge modeling of coupled heat flow and consolidation around hot cylinders buried in clay 显示文摘 | Britto A M Savvidou C Maddocks D V | 1989 | Geotechnique1989，39，1： | 1 |
| 12 | Handwritten digit segmentation : a comparative study 显示文摘 | Ribas F C Oliveira L S Britto Jr A S | 2013 | International Journal on Document Analysis and Recognition2013，16，2： | 1 |
| 13 | 998 Assessment of antitumor properties of the essential oil from the leaves of Guatteria Friesiana显示文摘 | BEZERRA D P BRITTO A C S OLIVEIRA A C A | 2012 | European Journal of Cancer2012，48，5： | 1 |
| 14 | Discoidin domain re- ceptor 1 on bone marrow-derived cells promotes macro- phage accumulation during atherogenesis 显示文摘 | Franco C Britto K Wong E | 2009 | Circ Res2009，105，： | 1 |
| 15 | A methodology for unveiling global innovation networks:patent citations as clues to cross border knowledge flows显示文摘 | Ribeiro L C Kruss G Britto G | 2014 | Scientometrics2014，101，1： | 1 |
| 16 | Comparisnn of debris extruded apieally and working time used by protaper universal rotary anti protaper retreatment system during gutta-percha removal显示文摘 | Uezu M K N Britto M L B Nabeshima C K | 2010 | Journal of Applied OraL Science2010，18，6： | 1 |
| 17 | Finite element analysis of the coupled heat flow and consolidation around hot buried objects显示文摘 | Britto A M Savvidou C Gunn M J Booker J R | 1995 | Soils and Foundations1995，，1： | 1 |
| 18 | Comparison of de- bris extruded apically and working time used by ProTaper Universal rotary and ProTaper retreatment system during gutta-percha removal 显示文摘 | Uezu M K N Britto M L B Nabeshima C K | 2010 | Journal of Applied Oral Science2010，18，6： | 1 |
| 19 | Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the RD mouse retina显示文摘 | Duvoisin RM Zhang C Hamassaki Britto DE | | 0，，： | 1 |
| 20 | Finite element analysis of the coupled heat flow and consolidation around hot buried objects显示文摘 | Britto A M Savvidou C Gunn M J | 1995 | Soils and Foundations1995，，1： | 1 |
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