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3篇 您的检索式:作者名="Brian Garvin"
    题名 作者 年代 出处 被引量
1The role of serotonin in irritable bowel syndrome: Implications for management显示文摘Brian Garvin John W. Wiley 2008Current Gastroenterology Reports2008,,4:2
2Science to support conservation action in a large river system:The Willamette River,Oregon,USA显示文摘Management and conservation efforts that support the recovery and protection of large rivers are daunting,reflecting the complexity of the challenge and extent of effort(in terms of policy,economic investment,and spatial extent)needed to afford measurable change.These large systems have generally experienced intensive development and regulation,compromising their capacity to respond to disturbances such as climate change orwildfire.Functionally,large river and basin management require insights gained from social,ecological,geophysical,and hydrological sciences.This multidisciplinary perspective can unveil the integrated relationship between a river network's biotic community and seasonally variableenvironmental conditions that are ofteninfluencedbyhumanactivities.Large rivers andtheir basins are constantly changing due to anthropogenic influences and as climate modifies patterns of temperature and precipitation.Because of these factors,the state of knowledge must advance to address changing conditions.The Willamette River,in western Oregon,USA,is a prime example of a basin that has experienced significant degradation and investment in rehabilitation in recent decades.Innovative science has facilitated development of fine-scale,spatially extensive datasets and models that can generate targeted conservation and rehabilitation actions that are prioritized across the entire river network.This prioritization allows investment decisions to be driven by site-specific conditions while simultaneously considering potentials for ecological improvement.Here,we review hydrologic,geomorphic,ecologic,and social conditions in the Willamette River basin through time—including pre-settlement,river development,andcontemporary periods—andoffer a futurevisionfor consideration.Currently,detailed informationaboutfish populations and habitat,hydrologic conditions,geomorphology,water quality,and land use can be leveraged to make informed decisions about protection,rehabilitation,and development.The time is ripe for strategic management and goal development for the entireWillamette River,and these efforts can be informed by comprehensive science realized through established institutions(e.g.,public agencies,non-profitwatershed groups,Tribes,and universities)focusedon conservation and management.The approaches to science and social-network creation that were pioneered in the Willamette River basin offer insights into thedevelopment of comprehensive conservation-based planning that could be implemented in other large river systems globally.Rebecca Flitcroft Luke Whitman James White Rose Wallick Laurel Stratton Garvin Cassandra Smith Robert Plotnikoff Michael Mulvey Tobias Kock Krista Jones Peter Gruendike Carolyn Gombert Guillermo Giannico Andrew Dutterer Daniel Brown Hannah Barrett Brian Bangs Robert M.Hughes 2023Water Biology and Security2023,2,4:0
3Cortical and spinal evoked potential response to electrical stimulation in human rectum显示文摘AIM: To study a novel technique to record spinal and cortical evoked potentials (EPs) simultaneously in response to electrical stimulation in the human rectum. METHODS: Eight male and nine female healthy volunteers participated. Stimulating electrodes were attached to the rectal mucosa at 15 cm and 12 cm above the dentate line. Recording skin electrodes were positioned over vertebrae L4 through S2. The electrical stimulus was a square wave of 0.2 ms duration and the intensity of the stimulus varied between 0 and 100 mA. EP responses were recorded using a Nicolet Viking IV programmable signal conditioner.RESULTS: Simultaneous recording of cortical and spinal EPs was obtained in > 80% of the trials. The EP responses increased with the intensity of the electrical stimulation, were reproducible overtime, and were blocked by application of Lidocaine jelly at the site of stimulation. The morphology (N1/P1), mean ± SD for latency (spinal N1, 4.6 ± 0.4 ms; P1, 6.8 ± 0.5 ms; cortical N1, 136.1 ± 4.2 ms; P1, 233.6 ± 12.8 ms) and amplitude (N1/P1, spinal, 38 ± 7 μV; cortical 19 ± 3 μV) data for the EP responses were consistent with those in the published literature. Reliable and reproducible EP recordings were obtained with the attachment of the electrodes to the rectal mucosa at predetermined locations between 16 and 8 cm above the anal verge, and the distance between the attachment sites of the electrodes (the optimal distance being approximately 3.0 cm between the two electrodes). CONCLUSION: This technique can be used to assess potential abnormalities in primary afferent neural pathways innervating the rectum in several neurodegenerative and functional pain disorders.Brian Garvin Lisa Lovely Alex Tsodikov Danielle Minecan Shaungson Hong John W Wiley 2010World Journal of Gastroenterology2010,16,43:0
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