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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-Analysis显示文摘 | Ulrike Peters Shuo Jiao Fredrick R. Schumacher Carolyn M. Hutter Aaron K. Aragaki John A. Baron Sonja I. Berndt Stéphane Bézieau Hermann Brenner Katja Butterbach Bette J. Caan Peter T. Campbell Christopher S. Carlson Graham Casey Andrew T. Chan Jenny Chan | 2012 | Gastroenterology2012，，： | 4 |
| 3 | Seronegative myasthenia gravis: clinical features, response to therapy and synthsis of acetylcholine receptor antibodies in vitro显示文摘 | Birmanns B Brenner T Abramsky O | 1991 | J Neurol Sci1991，102，2： | 2 |
| 4 | Small-cell carcinomas of the gastrointestinal tract : a review 显示文摘 | BRENNER B TANG LH KLIMSTRA DS | 2004 | J Clin Oncol2004，22，13： | 1 |
| 5 | Nitric oxide:a key factor behind thedysfunctionality of endothelial progenitor cells in diabetes mellitus type-2显示文摘 | Hamed S Brenner B Roguin A | 2011 | Cardiovasc Res2011，91，1： | 1 |
| 6 | Glomeruli and Blood Pressure:Less of One,More of the Other显示文摘 | Brenner B M Garcia D L Anderson S | 1988 | Hypertens1988，1，： | 1 |
| 7 | Diabetes and thyroid cancer risk in the National Institutes of Health-AARP Diet and Health Study显示文摘 | Aschebrook-Kilfoy B Sabra MM Brenner A | 2011 | Thyroid2011，21，： | 1 |
| 8 | Renoprotective benefits of RAS inhibition : from ACEI to angiotens in II antagonists 显示文摘 | TAAL M W BRENNER B M | 2000 | Kidney Int2000，57，5： | 1 |
| 9 | Hypercoagulability and recurrent miscarriages 显示文摘 | Brenner B | 2010 | Clin Adv Hematol Oncol2010，8，7： | 1 |
| 10 | Small bowel obstruction caused by secondary tumors显示文摘 | Idelevich E Kashtan H Mayor E Brenner B | 2006 | Surg Oncol2006，15，1： | 1 |
| 11 | Drug- related thrombosis in hematologic malignancies显示文摘 | Nadir Y Hoffman R Brenner B | 2004 | Rev Clin Exp Hematol2004，8，： | 1 |
| 12 | Organic geochemistry of recent sediments from Guaymas Basin 显示文摘 | Simoneit B R T Mazurek M Brenner S | 1979 | Gulf of California Deep Sea Res1979，26，： | 1 |
| 13 | DNA Commission of the ISFG (International Society of Forensic Genetics):recommendations on forensic analysis using Y-chromosome STRs显示文摘 | Gill P Brenner C Brinkmann B | 2001 | Int J Legal Med2001，114，6： | 1 |
| 14 | Theoretical kinetic studies of models for binding myosin subfragment-1 to regulated ac- tin : Hill model versus geeves model 显示文摘 | Chen Y Yan B Chalovich JM Brenner B | 2001 | Biophys J2001，80，： | 1 |
| 15 | Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty:a double-blind,randomised control ed trial显示文摘 | Kakkar AK Brenner B Dahl OE | | 0，，9632： | 1 |
| 16 | Heparanase induces tissue fac- tor expression in vascular endothelial and cancer ceils 显示文摘 | Nadir 'Y Brenner B Zetser A | 2006 | J Thromb Haemost2006，4，11： | 1 |
| 17 | Effects of enoxaparin on late pregnan- cy complications and neonatal outcome in women with recurrent preg- nancy loss and thrembophilia: resultsfrem the Live-Enox study 显示文摘 | Brenner B Bar J Ellis M | 2005 | Fertil Steril2005，84，3： | 1 |
| 18 | Mieropartieles and placental hemostasis 显示文摘 | Aharon A Brenner B | 2009 | Thromb Res2009，123，2： | 1 |
| 19 | Treatment of localized esophageal cancer显示文摘 | Brenner B Ilson DH Minsky BD | 2004 | Semin Oncol2004，，： | 1 |
| 20 | Molecular cloning of the pufferfish (Takifugu rubripes) Mx gene and functional characterization of its promoter显示文摘 | Yap W H Brenner S Venkatesh B | 2003 | Immunogenetics2003，54，： | 1 |
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