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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | SOFC technology development at Rolls-Royce显示文摘 | Gardner F J Day M J Brandon N P | 2000 | J Power Sources2000，86，： | 2 |
| 3 | 显示文摘 | Hart N Brandon N Day M | 2002 | J Power Sources2002，106，： | 1 |
| 4 | The direct electro- winning of gold from dilute cyanide leach liquors 显示文摘 | Brandon N P Mahmood M N Page P W | 1987 | Hydrometal- lurgy1987，18，3： | 1 |
| 5 | Modelling of cells,stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500 ~ 600 ℃显示文摘 | LEAH R T BRANDON N P AGUIAR P | 2005 | Power Sources2005，145，2： | 1 |
| 6 | Spinning-out a fuel cell com-pany froma UK University-2 years of progress at Ceres Power显示文摘 | Bance P Brandon N P Girvan B | | 0，，： | 1 |
| 7 | IcsA,a polarly localized autotransporter with an atypical signal peptide,uses the Sec apparatus for secretion,although the Sec apparatus is circumferentially distributed显示文摘 | Brandon LD Goehring N Janakiraman A | 2003 | Mol Microbiol2003，50，： | 1 |
| 8 | Delivery of the Cre recombinase by a self-deleting lentiviral vector:efficient gene targeting in vivo显示文摘 | Pfeifer A Brandon E P Kootstra N | 2001 | Proc Natl Acad Sci USA2001，98，11： | 1 |
| 9 | Modeling of ceils, stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500-600显示文摘 | Leah R T Brandon N P Aguiar P | 2005 | Journal of Power Sources2005，145，2： | 1 |
| 10 | How erosion builds mountains显示文摘 | PINTER N BRANDON M T | 1997 | Scientific American1997，276，： | 1 |
| 11 | Anode-supported intermediate temperature direct internal reforming solid oxide fuel cell I:model-based steady state performance显示文摘 | Aguiar P Adjiman C S Brandon N P | 2004 | Journal of Power Sources2004，138，12： | 1 |
| 12 | Influence of Potential on the Friction and Wear of Mild Steel in a Model Aqueous Lubricant显示文摘 | Brandon N P Bonanos N Fogarty P O | 1993 | J Appl Eleetrochem1993，23，： | 1 |
| 13 | The difference between selection and drift: a reply to Millsiein显示文摘 | Brandon R N | 2005 | Biology and Philosophy2005，20，： | 1 |
| 14 | Oceanographic variability and changes in Antarctic krill(Euphausia superba)abundance at South Georgia显示文摘 | Trathan P N Brierley A S Brandon M A | 2003 | Fish Oceanogr2003，12，6： | 1 |
| 15 | Development of metal supported solid oxide fuel cells for operation at 500-600℃显示文摘 | Corcoran D Ducker A | 2004 | Jouranl of Materials Engineering and Performance2004，13，3： | 1 |
| 16 | Recent advances in materials for fuel cells 显示文摘 | BRANDON N P SKINNER S STEELE B C H | 2003 | Annu Rev Mater Res2003，33，： | 1 |
| 17 | Anode-supported intermediate temperature direct internal reforming solid oxide fuel cell II: model-based dynamic performance and control显示文摘 | Aguiar P Adjiman C S Brandon N P | 2005 | Journal of Power Sources2005，147，12： | 1 |
| 18 | Study of Loss Mechanisms Using Half- Cell Measurements in a Regenerative Hydrogen Vanadium Fuel Cell 显示文摘 | Dewage H H Yufit V Brandon N P | 2016 | J Electrochem Soc2016，163，1： | 1 |
| 19 | Application of thermal imaging to validate a heat transfer model for polymer electrolyte fuel cells 显示文摘 | Matian M Marquis A Brandon N | 2012 | International Journal of Hydrogen Energy2012，35，12： | 1 |
| 20 | Porcine mannan-binding lectin A binds to actinobacillus snis and Hatmophilus parasuu显示文摘 | Brandon N L Jutta D H Janet I M | 2006 | Developmental and Comparative Immunology2006，30，： | 1 |
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