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| 1 | Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry显示文摘Background In a three-month report from the CGA-TAVI registry, we found the Multidimensional Prognostic Index (MPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. Methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the MPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan- Meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk MPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating MPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The MPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients. | Martijn S.van Mourik Nathalie van der Velde Giulio Mannarino Marie-Pierre Thibodeau Jean-Bernard Masson Gennaro Santoro Jan Baan Sofie Jansen Jana Kurucova Martin Thoenes Cornelia Deutsch ANDreas W.Schoenenberger ANDrea Ungar Peter Bramlage M Marije Vis | 2019 | Journal of Geriatric Cardiology2019，16，6： | 3 |
| 2 | Treatment of peripheral arterial disease using stem and progenitor cell therapy 显示文摘 | Lawall H Bramlage P Amann B | 2011 | J Vase Surg2011，53，2： | 1 |
| 3 | Non-steroidal mineralocorticoid receptor antagonism for the treatment of cardiovascular and renal disease 显示文摘 | Bramlage P Swift S L Thoenes M | 2016 | Eur J Heart Fail2016，18，1： | 1 |
| 4 | Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs 显示文摘 | SoutschekJ Akinc A Bramlage B | 2004 | Nature2004，432，7014： | 1 |
| 5 | Comparison of 3,000 and 5,000 IU aXa/day certoparin in the prevention of deep-vein thrombosis after total hip replacement显示文摘 | Bramlage P Michaelis HC Melzer N | | 0，，01： | 1 |
| 6 | Therapeutic silen- cing of an endogenous gene by systemic administration of modified siRNAs显示文摘 | Soutschek J Akinc A Bramlage B | 2004 | Nature2004，432，7014： | 1 |
| 7 | Cost-effectiveness of the artificial liver support system MARS in patients with acute-on-chronic liver failure 显示文摘 | Hessel FP Bramlage P Wasem J | 2010 | Eur J Gastroenteroi Hepatol2010，22，2： | 1 |
| 8 | Comparison of selective AT1-receptor blockade versus ACE inhibition for restenosis prophylaxis in patients with peripheral occlusive arterial disease after stent angioplasty: a randomized, controlled, proaf-of-eoncept study显示文摘 | Schindler C Mueller A Bramlage P | 2007 | Angiology2007，58，6： | 1 |
| 9 | Role of the vasodilator peptide angiotensin-( 1-7 ) in cardiovascular drug therapy显示文摘 | Schindler C Bramlage P Kirch W Ferrario C M | 2007 | Vasc Health Risk Manag2007，3，： | 1 |
| 10 | Developmental changes of cuticular con-stituents and their association with ethylene during fruit ripening in‘Delicious’ apples显示文摘 | JU Z G BRAMLAGE W J | 2001 | Postharvest Biology and Technology2001，21，3： | 1 |
| 11 | Nephropathy : an overview for daily practice 显示文摘 | Pittrow D Wittchen HU Bramlage P | 2003 | Fortschr Med Orig2003，121，1： | 1 |
| 12 | Diabetes treatment patterns and goal achievement in primary diabetes care ( DiaRegis )-study protocol and patient characteristics at baseline显示文摘 | Bramlage P Binz C Gitt AK | 2010 | Cardiovasc Diabetol2010，53，9： | 1 |
| 13 | Superficial scald of‘Granny Smith'apples is exp ressed as a typical chilling injury显示文摘 | Watkins C B Bramlage W J Cregoe B A | 1995 | American Society Horticulture Science1995，120，1： | 1 |
| 14 | Frequency of albuminu- ria in primary care: a cross-sectional study 显示文摘 | Bramlage P Pittrow D Lehnert H | 2007 | Eur J Cardiovasc Prey Rehabil2007，14，1： | 1 |
| 15 | Comparison of calcium chloride,calcium phophate,and a calcium chelate as foliar sprays for MICNTOSH apple trees显示文摘 | BRAMLAGE W J | 1985 | J Amer Soc Hort1985，110，6： | 1 |
| 16 | Roles of ethylene in the development of superficial scald in Cortland apples显示文摘 | Du Z J Bramlage W J | 1994 | American Society Horticulture Science1994，119，3： | 1 |
| 17 | Cost effectiveness of the artificial liver support system MARS in patients with acute on chronic liver failure显示文摘 | Hessel FP Bramlage P Wasem J | 2010 | Eur J Gastroenterol Hepatol2010，22，2： | 1 |
| 18 | Interaction of orchard factors and mineral nutrition on quality of pome fruit显示文摘 | Bramlage W J | 1993 | Acta Hort1993，32，6： | 1 |
| 19 | Modulatory effects of inflammation and therapy on GDF-5 expression in rheumatoid arthritis synovium显示文摘 | BRAMLAGE C P KAPS C UNGETHUM U | 2008 | Scand J Rheumatol2008，37，6： | 1 |
| 20 | The influence of mineral nutrition on the quality and storage performance of pome fruits grown in North America 显示文摘 | Bramlage W J Drake M Lord W J | 1980 | Acta Horticuhurae1980，，92： | 1 |
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