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| 1 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis显示文摘AIM:To investigate the significance of Thrombospondin-1 (TSP-1) expression and its relationship with angiogenesis during experimental fibrosis. METHODS:Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN). The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS:Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis (GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P < 0.05). Moreover, TSP-1 expression was found to be correlated with angiogenesis (P < 0.05). CONCLUSION:The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 (TGF-β1), TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver. | Gülsüm zlem Elpek Güzide Ayse Gkhan Sevgi Bozova | 2008 | World Journal of Gastroenterology2008，14，14： | 7 |
| 2 | An unusual cause of cholecystitis:Heterotopic pancreatic tissue in the gallbladder显示文摘Gallbladder localization of heterotopic pancreas (HP) is uncommon and very rarely gives rise to symptoms. Herein we report a case of HP found in the gallbladder neck presented with signs and symptoms of cholecystitis. The patient was a 40-year old male, suffering from epigastric pain, abdominal fullness and fever. On physical examination, the right upper abdomen was tender with a positive Murphy’s sign. Ultrasonographic examination showed a hydropic gallbladder without stones and he underwent a cholecystectomy. Pathological examination revealed an intramural nodule (9 mm) in the neck region which is consisted of acini, ducts and islet cells of an aberrant pancreatic tissue. Although HP is encountered rarely in the gallbladder and is found incidentally during pathological studies, this case emphasizes that HP might cause symptoms and present clinically as cholecystitis. For this reason, in patients presenting with symptomatic gallbladder diseases, including cholecystitis without any other pathology, HP should be taken into consideration before it is diagnosed as 'idiopathic’’. | Glsm zlem Elpek Sevgi Bozova Gkben Y■d■r■m Kpesiz Mehmet ■■ | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 3 | Hypoxia-inducible factor-1alpha expression in experimental cirrhosis:correlation with vascular endothelial growth factor expression and angiogenesis显示文摘 | Bozova S Elpek GO | | 0，，07： | 1 |
| 4 | Hypoxia-inducible factor-lalpha expression in experimental cirrhosis: correlation with vascular endothelial growth factor expression and angiogenesis显示文摘 | Bozova S Elpek GO | 2007 | APMIS2007，115，7： | 1 |
| 5 | Inflammatory myofibroblastic tumor of the liver: a case report显示文摘 | Sürer E Bozova S G?khan GA | 2009 | Turk J Gastroenterol2009，20，2： | 1 |
| 6 | H-ras oncogene expression and angiogenesis in experimental liver cirrhosis 显示文摘 | Elpek GO Unal B Bozova S | 2013 | Gastroenterol Res Pract2013，8689，： | 1 |
| 7 | Hypoxia - inducible factor - 1 αexpression in experimental cirrhosis: correlation with vascular endothelial growth factor expression and angiogenesis 显示文摘 | Bozova S Elper G O | 2007 | APM1S2007，115，7： | 1 |
| 8 | Hypoxia-inducible factor-1α expression in experimental cirrhosis: corelation with vascular endothelial growth factor expression and angiogenesis显示文摘 | BOZOVA S ELPEK G O | 2007 | APMIS2007，115，： | 1 |
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