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您的检索式：作者名="Bozhen Wang"
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| 1 | Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen receptor transduced T cells显示文摘Recent progress in chimeric antigen receptor-modified T-cell(CAR-T cell) technology in cancer therapy is extremely promising, especially in the treatment of patients with B-cell acute lymphoblastic leukemia. In contrast, due to the hostile immunosuppressive microenvironment of a solid tumor, CAR T-cell accessibility and survival continue to pose a considerable challenge, which leads to their limited therapeutic efficacy. In this study, we constructed two anti-MUC1 CAR-T cell lines. One set of CAR-T cells contained SM3 single chain variable fragment(sc Fv) sequence specifically targeting the MUC1 antigen and co-expressing interleukin(IL) 12(named SM3-CAR). The other CAR-T cell line carried the SM3 sc Fv sequence modified to improve its binding to MUC1 antigen(named p SM3-CAR) but did not co-express IL-12. When those two types of CAR-T cells were injected intratumorally into two independent metastatic lesions of the same MUC1+ seminal vesicle cancer patient as part of an interventional treatment strategy, the initial results indicated no side-effects of the MUC1 targeting CAR-T cell approach, and patient serum cytokines responses were positive. Further evaluation showed that p SM3-CAR effectively caused tumor necrosis, providing new options for improved CAR-T therapy in solid tumors. | Fengtao You Licui Jiang Bozhen Zhang Qiang Lu Qiao Zhou Xiaoyang Liao Hong Wu Kaiqi Du Youcai Zhu Huimin Meng Zhishu Gong Yunhui Zong Lei Huang Man Lu Jirong Tang Yafen Li Xiaochen Zhai Xiangling Wang Sisi Ye Dan Chen Lei Yuan Lin Qi Lin Yang | 2016 | Science China(Life Sciences)2016，59，4： | 16 |
| 2 | Microwave synthesis of chain-like zircona nanofibers through carbon-induced self-assembly growth显示文摘 | Wanyu ZHAO Jian LI Bingbing FAN Gang SHAO Hailong WANG Bozhen SONG Shengnan WEI Rui ZHANG | 2017 | Frontiers of Materials Science2017，11，4： | 1 |
| 3 | Unlocking the bacterial contact-dependent antibacterial activity to engineer a biocontrol alliance of two species from natural incompatibility to artificial compatibility显示文摘Plant growth-promoting rhizobacteria(PGPR)contain various biocontrol bacteria with broad-spectrum antimicrobial activity,and their single species has been extensively applied to control crop diseases.The development of complex biocontrol community by mixing two or more PGPR members together is a promising strategy to enlarge the efficacy and scope of biocontrol.However,an effective method to assess the natural compatibility of PGPR members has not yet been established to date.Here,we developed such a tool by using the bacterial contactdependent antibacterial activity(CDAA)as a probe.We showed that the CDAA events are common in two-species interactions in the four selected representative PGPRs,represented by the incompatible interaction of Lysobacter enzymogenes strain OH11(OH11)and Lysobacter antibioticus strain OH13(OH13).We further showed that the CDAA between OH11 and OH13 is jointly controlled by a contact-dependent killing device,called the type IV secretion system(T4SS).By deleting the respective T4SS synthesis genes,the T4SS in both strains was co-inactivated and this step unlocked their natural CDAA,resulting in an engineered,compatible mutant alliance that co-displayed antibacterial and antifungal activity.Therefore,this study reveals that releasing bacterial CDAA is effective to rationally engineer the biocontrol community. | Qianhua Wu Bozhen Wang Xi Shen Danyu Shen Bingxin Wang Qinggang Guo Tao Li Xiaolong Shao Guoliang Qian | 2021 | Stress Biology2021，1，1： | 1 |
| 4 | Fatigue Behaviour of Tubular Joints Made of China-Made Platform Steel显示文摘In China, a nationwide research program on fatigue behaviour of tubular joints made of China-made platform steel was carried out from 1983 to 1990, which was set by the Tubular Joint Research Committee for Offshore Structures (TJCOS) of China. This paper gives an outline of the basic properties of the China-made platform steel and fatigue test of tubular joints, including test specimens, test particulars and test results. A p-S-N curve based on the test results was established which reveals that the fatigue strength of tubular joints is fairly good. The thickness effect and effect of corrosion on fatigue strength in sea water are briefly discussed. | Wang Gnanghai and Chen Bozhen Senior Research Engineer, China Ship Scientific Research Center (CSSRC), Wuxi Professor, Shanghai Jiao Tong University, Shanghai | 1992 | China Ocean Engineering1992，7，1： | 1 |
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