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| 1 | Comparative effectiveness of traditional chemoembolization with or without sorafenib for hepatocellular carcinoma显示文摘AIM: To compare the overall survival (OS) and progression-free survival (PFS) with associated adverse events (AE) in patients with unresectable hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) + sorafenib vs TACE alone. METHODS: In this retrospective cohort study we collected data on all consecutive patients with a diagnosis of unresectable HCC between 2007 and 2011 who had been treated with TACE + sorafenib or TACE alone. We hypothesized that the combination therapy is superior to TACE alone in improving the survival in these patients. Data extracted included patient's demographics, etiology of liver disease, histology of HCC, stage of liver disease with respect to model of end stage liverdisease score and Child-Turcotte-Pugh (CTP) classification and Barcelona Clinic Liver Cancer (BCLC) staging for HCC. Computed tomography scan findings, alpha fetoprotein levels, number of treatments and related AE were also recorded and analyzed. RESULTS: Of the 43 patients who met inclusion criteria, 13 were treated with TACE + sorafenib and 30 with TACE alone. There was no significant difference in median survival: 20.6 mo (95%CI: 13.4-38.4) for the TACE + sorafenib and 18.3 mo (95%CI: 11.8-32.9) for the TACE alone (P = 0.72). There were also no statistically significant differences between groups in OS (HR = 0.82, 95%CI: 0.38-1.77; P = 0.61), PFS (HR = 0.93, 95%CI: 0.45-1.89; P = 0.83), and treatment-related toxicities (P = 0.554). CTP classification and BCLC staging for HCC were statistically significant (P = 0.001, P = 0.04 respectively) in predicting the survival in patients with HCC. The common AE observed were abdominal pain, nausea, vomiting and mild elevation of liver enzymes. CONCLUSION: Combination therapy with TACE + sorafenib is safe and equally effective as TACE alone in patients with unresectable HCC. CTP classification and BCLC staging were the significant predictors of survival. Future trials with large number of patients are needed to further validate this observation. | Adnan Muhammad Manish Dhamija Gitanjali Vidyarthi Donald Amodeo William Boyd Branko Miladinovic Ambuj Kumar | 2013 | World Journal of Hepatology2013，5，7： | 16 |
| 2 | Multifunctional Land Use --An Opportunity for Promoting Urban Agriculture in Europe显示文摘 | Tjeerd Deelstra Donald Boyd Maaike van den Biggelaar | 2001 | Urban Agriculture Magazine2001，，4： | 1 |
| 3 | Measuring Test Measurement Error:A General Approach 显示文摘 | Boyd Donald Lankford Hamilton Loeb Susanna | 2013 | Journal of Educational and Behavioral Statistics2013，38，6： | 1 |
| 4 | The Influence of School Administrators on Teacher Retention Decisions显示文摘 | Donald Boyd Pamela Grossman Marsha Ing Hamihon Lankford Susanna Loeb James Wyckoff | 2011 | Amer- ican Education Research Journal2011，48，2： | 1 |
| 5 | Exposures to carbon monoxide,hydrogen cyanide and their mixtures: Interrelationship between gas exposure concentration, time to incapacitation, carboxyhemoglobin and blood cyanide in rats显示文摘 | Arvind K Donald C Boyd R | 1995 | Journal of Applied Toxicology1995，15，5： | 1 |
| 6 | Initial evaluation of the acute and chronic multiple ligament injured knee显示文摘 | Vinyard TR Boyd J Mac Donald PB | 2012 | J Knee Surg2012，25，4： | 1 |
| 7 | Summary and recommendations of the fourth international workshop-conference on gestational diabetes mellitus显示文摘 | Boyd EM Donald RC | 1998 | Diabetes Care1998，21，： | 1 |
| 8 | The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: paving the way for new diagnostic criteria for gestational diabetes mellitus显示文摘 | Donald R. Coustan Lynn P. Lowe Boyd E. Metzger Alan R. Dyer | 2010 | American Journal of Obstetrics and Gynecology2010，，6： | 1 |
| 9 | The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: paving the way for new diagnostic criteria for gestational diabetes mellitus显示文摘 | Donald R. Coustan Lynn P. Lowe Boyd E. Metzger Alan R. Dyer | 2010 | American Journal of Obstetrics and Gynecology2010，，6： | 1 |
| 10 | The Kock Ileal Neobladder: Updated Experience in 295 Male Patients显示文摘 | Donald A. Elmajian John P. Stein David Esrig John A. Freeman Eila C. Skinner Stuart D. Boyd Gary Lieskovsky Donald G. Skinner | 1996 | The Journal of Urology1996，，3： | 1 |
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