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| 1 | Management of hepatocellular carcinoma in the elderly显示文摘Mean age of hepatocellular carcinoma(HCC) patients has been progressively increasing over the last decades and ageing of these patients is becoming a real challenge in every day clinical practice. Unfortunately, international guidelines on HCC management do not address this problem exhaustively and do not provide any specific recommendation. We carried out a literature search in MEDLINE database for studies reporting on epidemiology, clinical characteristics and treatment outcome of HCC in elderly patients. Available data seem to indicate that in elderly patients the outcome of HCC is mostly influenced by liver function and tumor stage rather than by age and the latter should not influence treatment allocation. Age is not a risk for resection and older patients with resectable HCC and good liver function could gain benefit from surgery. Mild comorbidities do not seem a contraindication for surgery in aged patients. Conversely, major resection in elderly, even when performed in experienced high-volume centres, should be avoided. Both percutaneous ablation and transarterial chemoembolization are not contraindicated in aged patients and safety profile of these procedures is acceptable. Sorafenib is a viable option for advanced HCC in elderly provided that a careful evaluation of concomitant comorbidities, particularly cardiovascular ones, is taken into account. Available data seem to suggest that in either elderly and younger, treatment is a main predictor of outcome. Consequently, a nihilistic attitude of physicians towards under- or no-treatment of aged patients should not be longer justified. | Mauro Borzio Elena Dionigi Giancarlo Parisi Ivana Raguzzi Rodolfo Sacco | 2015 | World Journal of Hepatology2015，7，11： | 2 |
| 2 | Survival benefit of liver resection for patients with hepatocellular carcinoma across different Barcelona Clinic Liver Cancer stages: a multicentre study显示文摘 | Alessandro Vitale Patrizia Burra Anna Chiara Frigo Franco Trevisani Fabio Farinati Gaya Spolverato Michael Volk Edoardo G. Giannini Francesca Ciccarese Fabio Piscaglia Gian Lodovico Rapaccini Mariella Di Marco Eugenio Caturelli Marco Zoli Franco Borzio Gi | 2014 | Journal of Hepatology2014，，： | 2 |
| 3 | Barcelona Clinic Liver Cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study显示文摘 | Alessandro Vitale Rafael Ramirez Morales Giacomo Zanus Fabio Farinati Patrizia Burra Paolo Angeli Anna Chiara Frigo Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Catur | 2011 | Lancet Oncology2011，，7： | 2 |
| 4 | Hepatocyte proliferation rate is a powerful parameter for predicting hepatocellular carcinoma development in liver cirrbosis显示文摘 | Borzio M Trere D Borzio F | 1998 | Mol pathol1998，51，2： | 1 |
| 5 | Advanced precancer- ous lesions in the liver显示文摘 | Tommaso L D Sangiovanni A Borzio M | 2013 | Best Practice & Research Clinical Gastro- enterology2013，27，2： | 1 |
| 6 | Translocation of gut bacteria in rats with cirrhosis to mesenteric lymph nodes partially explains the pathogenesis of spontaneous bacterial peritonitis显示文摘 | Runyon BA Squier S Borzio M | 1994 | J Hepatol1994，21，5： | 1 |
| 7 | Ad- vanced precancerous lesions in the liver显示文摘 | DI TOMMASO L SANGIOVANNI A BORZIO M | 2013 | Best Pract Res Clin Gastroenterol2013，27，2： | 1 |
| 8 | Translocation of gut bacteria inratswith cirrhosis to mesenteric lymph nodes partially explains the pathogenesis of spontaneous bac- terial peritonitis显示文摘 | Runyon BA Squier S Borzio M | 1994 | J hepatol1994，21，5： | 1 |
| 9 | Cost-effectiveness of semi-annual surveillance for hepatocellular carcinoma in cirrhotic patients of the Italian Liver Cancer population显示文摘 | Alessandro Cucchetti Franco Trevisani Matteo Cescon Giorgio Ercolani Fabio Farinati Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Caturelli Maria Chiaramonte Antonio D | 2012 | Journal of Hepatology2012，，5： | 1 |
| 10 | Bacterial infection in patients with advanced cirrhosis:a multicentre prospective stuay显示文摘 | Salerno E Piantoni L | 2001 | Dig Liver Dis2001，33，： | 1 |
| 11 | Translocati0n of gut bacteria in ratswith cirrhosis to mesenteric lymph nodes partially explains the pathogenesis of spontaneous bacterial peritonitis 显示文摘 | Runyon BA Squier S Borzio M | 1994 | J Hepatol1994，21，5： | 1 |
| 12 | Bacterial infection in patients with advanced cirrhosis:a multicentre prospective study显示文摘 | Salerno F Piantoni L | 2001 | Dig Liver Dis2001，33，： | 1 |
| 13 | Barcelona Clinic Liver Cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study显示文摘 | Alessandro Vitale Rafael Ramirez Morales Giacomo Zanus Fabio Farinati Patrizia Burra Paolo Angeli Anna Chiara Frigo Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Catur | 2011 | Lancet Oncology2011，，7： | 1 |
| 14 | Hepatocyte proliferation rate is a powerful parameter for predicting hepatocellular carcinoma development in liver cirrhosis显示文摘 | Borzio M Trere D Borzio F | 1998 | Mol Pathol1998，51，2： | 1 |
| 15 | The changing scenario of hepatocellular carcinoma over the last two decades in Italy显示文摘 | Valentina Santi Daniela Buccione Antonio Di Micoli Gianluca Fatti Marta Frigerio Fabio Farinati Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Caturelli Maria Chiaramon | 2011 | Journal of Hepatology2011，，2： | 1 |
| 16 | Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: A prospective study显示文摘 | Borzio M Bruno S Roncalli M | 1995 | Gastroenterology1995，108，： | 1 |
| 17 | Bacterial infection in patients with advanced cirrhosis:a muhieentre prospective study显示文摘 | Borzio M Salerno F Piantoni L | 2001 | Dig Liver Dis2001，33，： | 1 |
| 18 | Bacterial infection in patients with advanced cirrhosis : a multicentre prospective study显示文摘 | BORZIO M SALERNO F PIANTONI L | 2001 | Dig Liver Dis2001，33，1： | 1 |
| 19 | The changing scenario of hepatocellular carcinoma over the last two decades in Italy显示文摘 | Valentina Santi Daniela Buccione Antonio Di Micoli Gianluca Fatti Marta Frigerio Fabio Farinati Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Caturelli Maria Chiaramon | 2011 | Journal of Hepatology2011，，2： | 1 |
| 20 | Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study显示文摘 | Borzio M Salerno F Piantoni L | 2001 | Dig Liver Dis2001，33，1： | 1 |
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