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| 1 | Fat:A matter of disturbance for the immune system显示文摘Obesity is increasingly being recognized as a risk factor for a number of benign and malignant gastrointestinal conditions. However, literature on the underlying pathophysiological mechanisms is sparse and ambiguous. There is compelling evidence that both overnutrition and undernutrition negatively interfere with the immune system. Overnutrition has been found to increase susceptibility to the development of inflammatory diseases, autoimmune diseases and cancer. In the regulation of immune and in? ammatory processes, white adipose tissue plays a critical role, not only as an energy store but also as an important endocrine organ. The obese state is characterised by a low-grade systemic in? ammation, mainly as a result of increased adipocytes as well as fat resident-and recruited-macrophage activity. In the past few years, various products of adipose tissue including adipokines and cytokines have been characterised and a number of pathways linking adipose tissue metabolism with the immune system have been identified. Activation of the innate immune system plays a major role in hepatic steatosis. Non-alcoholic fatty liver disease includes a wide spectrum of diseases, from pure steatosis to non-alcoholic steato-hepatitis in the absence of signif icant alcohol consumption. Although steatosis is considered a non-progressive disease, non-alcoholic steatohepatitis may deteriorate in advanced chronic liver diseases, cirrhosis, and hepatocellular carcinoma. An important parallel between obesityrelated pathology of adipose tissue and liver pertains to the emerging role of macrophages, and growing evidence suggests that Kupffer cells critically contribute to progression of non-alcoholic fatty liver disease. Moreover, a close link between specif ic immune activation and atherosclerosis has been well established, suggesting that fat can directly trigger immune responses. This review discusses the role of fat as 'a matter of disturbance for the immune system' with a focus on hepatic steatosis. | Alessandro Federico Elena D’Aiuto Francesco Borriello Giusi Barra Antonietta Gerarda Gravina Marco Romano Raffaele De Palma | 2010 | World Journal of Gastroenterology2010，16，38： | 12 |
| 2 | 抗生素耐药性环境中产生和转移的人类健康风险评估(HHRA)显示文摘[背景]直到最近,人们才明确环境能影响抗生素耐药性风险对临床结果的影响,但迄今为止,很少有文献记录正式评估这些风险的方法。[目标]我们研究可能的方法,并试图确定人类健康风险评估(HHRA)的研究需求,这项评估注重环境在抗生素耐药性病原体所致的抗生素治疗失败中所起的作用。[方法]作者参加了2012年3月4—8日在加拿大魁北克省举行的研讨会,定义抗生素耐药性风险与人类健康环境评估的范围和目标。我们专注于环境中耐药性产生'热点区域'的关键要素,(与食品无关的)暴露评估以及剂量反应,以描述风险特征,从而改善抗生素耐药性管理的方案。[讨论]识别传统风险评估中有助于评估环境中抗生素耐药性的各个新方面。包括:a)解释附加的选择压力对环境耐药基因组的作用,即随着时间的推移,促使抗生素耐药性细菌(ARB)产生;b)在相关的环境组成部分的'热点区域'中识别和描述水平基因转移(HGT)率;c)针对不同健康结局和途径的ARB剂量修改传统的剂量反应方法。[结论]我们建议将抗生素耐药性产生造成的环境影响纳入所有涉及ARB的HHRA过程之中。由于可用的数据有限,一种多标准决策分析方法将有助于进行环境中抗生素耐药性的HHRA,并使风险管理者了解环境抗生素耐药性。 | Nicholas J.Ashbolt Alejandro Amézquita Thomas Backhaus Peter Borriello Kristian K.Brandt Peter Collignon Anja Coors Rita Finley William H.Gaze Thomas Heberer John R.Lawrence D.G.Joakim Larsson Scott A.McEwen James J.Ryan Jens Schnfeld Peter Silley Jason R.Snape Christel Van den Eede Edward Topp 王晓宇 张伊人 操仪 | 2014 | 环境与职业医学2014，31，2： | 3 |
| 3 | Location Systems for Ubiquitous Computing 显示文摘 | Jeffrey Hightower Gaetano Borriello | 2001 | IEEE Computer2001，34，8： | 2 |
| 4 | Building the Internet of Things Using RFID: The RFID Ecosystem Experience显示文摘 | Welbourne Evan Battle Leilani Cole Garret Gould Kayla Rector Kyle Raymer Samuel Balazinska Magdalena Borriello Gaetano | 2009 | IEEE Internet Computing2009，，3： | 2 |
| 5 | Embeddingthe Internet:Embedded computation Meets the World Wide Web显示文摘 | Borriello G Want R | 2000 | Communication of ACM2000，43，： | 1 |
| 6 | Resveratrol: from basic studies to bedside 显示文摘 | Borriello A Bencivenga D Caldarelli I | 2014 | Cancer Treat Res2014，159，： | 1 |
| 7 | Location systems for ubiquitous computing显示文摘 | HIGHTOWER J BORRIELLO G | 2001 | Computer2001，34，8： | 1 |
| 8 | Loss of CTLA-4 Leads to Massive Lymphoproliferation and Fatal Multiorgan Tissue Destruction,Revealing a Critical Negative Regulatory Role of CTLA-4显示文摘 | TIVOL EA BORRIELLO F SCHWEITZER AN | 1995 | Immunity(S0889-1591)1995，3，5： | 1 |
| 9 | Polymerization of 3-methyl-1-butene promoted by metallocene catalysts显示文摘 | Borriello A Busico V Cipullo R | 1996 | Macromol Rapid Commm1996，17，8： | 1 |
| 10 | Location Systems for Ubiquitous Computing显示文摘 | Hightower J Borriello G | 2001 | IEEE Computer2001，1，34： | 1 |
| 11 | Natalizumab treatment in pediatric multiple sclerosis: a case report 显示文摘 | BORRIELLO G PROSPERINI L LUCHETI'I A | 2009 | Eur J Paediatr Neurol2009，13，： | 1 |
| 12 | Loss of CTLA-4 Leads to Massive Lymphoproliferation and Fatal Muhiorgan Tissue Destruction, Revealing a Critical Negative Regulatory Role of CTLA-4显示文摘 | Tirol EA Borriello F Schweitzer AN | 1995 | Immunity1995，3，5： | 1 |
| 13 | Survey on Information Appliances显示文摘 | Borriello G | 2000 | IEEE Computer Graphics and Applications2000，20，3： | 1 |
| 14 | Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4显示文摘 | Elizabeth A. Tivol Frank Borriello A.Nicola Schweitzer William P. Lynch Jeffrey A. Bluestone Arlene H. Sharpe | 1995 | Immunity1995，，5： | 1 |
| 15 | Embedded Computation Meets the WorldWide-Web显示文摘 | Want R | 2000 | Communications of the ACM2000，43，5： | 1 |
| 16 | Disappearing hardware 显示文摘 | Want R Borriello G Pering T | 2002 | IEEE Pervasive Computing2002，1，1： | 1 |
| 17 | Multiple routine alpha 1-protease inhibitor genes show unusual evolutionary divergence显示文摘 | Borriello F Krauter K S | 1991 | Proc Natl Acad Sci USA1991，88，21： | 1 |
| 18 | Resveratrol: from basic studies to bedside 显示文摘 | Borriello A Bencivenga D Caldarelli I etal | 2014 | Cancer Treat Res2014，159，： | 1 |
| 19 | Loss of CTLA-4 leads to massivelymphoproliferation and fatal muhiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4显示文摘 | Tivol EA Borriello F Schweitzer AN | 1995 | Immunity1995，3，5： | 1 |
| 20 | on resveratrol, a promising agent in the prevention of cardiovascular diseases and control of glucose homeostasis 显示文摘 | Borriello A Cucciolla V Dietary polyphenols: Focus Della Ragione F | 2010 | Nutr Metab Cardiovas2010，20，： | 1 |
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