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| 1 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 2 | Anatomy of the portal branches and the hepatic veins in the candate lobe of the liver 显示文摘 | Ortale JR Borges Keiralla LC | 2004 | Surg Radial Anat2004，26，4： | 1 |
| 3 | Tonin in rat heart with experimental hypertrophy显示文摘 | BORGES J C SILVA J A Jr GOMES M A | 2003 | Am J Physiol Heart Circ Physiol2003，284，6： | 1 |
| 4 | Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction 显示文摘 | Bonetti TC Borges E Jr Braga DP | 2013 | Reprod Biomed Online2013，26，1： | 1 |
| 5 | Tonin in rat heart with experimental hypertrophy显示文摘 | Borges JC Silva JA Jr Gomes MA | 2003 | Am J Physiol Heart Circ Physiol2003，284，6： | 1 |
| 6 | Anatomy of the portal branches and the hepatic veins in the caudate lobe of the liver显示文摘 | Ortale JR Borges KLC | 2004 | Surg Radiol Anat2004，26，5： | 1 |
| 7 | Micro-biological composition associated with vitamin D receptor gene polymorphism in chronic periodontitis显示文摘 | Borges MA Figueiredo LC Brito RB Jr | 2009 | Braz Oral Res2009，23，2： | 1 |
| 8 | Kihler's bone disease of the tarsal navicular 显示文摘 | Borges JL Guille JT Bowen JR | 1995 | J Pediatr Orthop1995，15，5： | 1 |
| 9 | Tonin in rat heart with experimental hypertrophy显示文摘 | Borges JC Silva JA Jr Comes MA | 2003 | Am J Physiol Heart Circ Physiol2003，284，6： | 1 |
| 10 | Tonin in rat heart with experimental hypertrophy显示文摘 | Borges JC Silva JA Jr Gomes MA | 2003 | Am J Physiol Heart Circ Physiol2003，284，6： | 1 |
| 11 | Proinflammatory and oxidative stress markers in patients with periodontal disease显示文摘 | Borges Jr I Moreira EAM De Oliveira TB | 2007 | Me?diators Inflamm2007，2007，45： | 1 |
| 12 | An improved method for the determination of petroleum hydrocarbons from soil using a simple ultrasonic extraction and fourier transform infrared spectrophotometry显示文摘 | Couto MN Borges JR Guedes P Almeida R Monteiro E Almeida CMR Basto MCP Vaseoncelos MTSD | 2014 | Petroleum Science and Technology2014，32，4： | 1 |
| 13 | Effect of crystallization rate on the formation of the polymorphs of solution east poly (vinylidene fluoride) 显示文摘 | GREGORIO R Jr BORGES D S | 2008 | Polymer2008，49，18： | 1 |
| 14 | Spinal dural arteriove- nous fistulas: experience with endovascular and surgical therapy显示文摘 | Eskandar EN Borges LF Budzik RF Jr | 2002 | J Neurosurg2002，96，2： | 1 |
| 15 | Spinal dural arteriovenous fistulas:experience with endovascular and surgical therapy显示文摘 | Eskandar EN Borges LF Budzik RF Jr | 2002 | J Neurosurg( Spine 2 )2002，96，： | 1 |
| 16 | Influence of the curing mode on the degree of conversion of a dual-cured self-adhesive resin luting cement beneath ceramic显示文摘 | Souza EJ Jr Borges BC Oliveira DC | 2013 | Acta Odontol Scand2013，71，34： | 1 |
| 17 | Spinal dural arteriovenous fistulas:experience with endovascular and surgical therapy显示文摘 | Eskandar E N Borges L F Budzik Jr R F | 2002 | J Neurosurg2002，96，2： | 1 |
| 18 | Pneumatic dilation versus laparoscopie Heller myotomy for the treatment of achalasia: variables related to a good response 显示文摘 | Borges AA Lemme EM Abrahao LJ Jr | 2014 | Dis Esophagus2014，27，1： | 1 |
| 19 | Acellular dermal matrix as a barrier in guided bone regeneration : aclinical, radiographic and histomorphometric study in dogs 显示文摘 | Borges GJ Novaes AB Jr Grisi MF | 2009 | Clin Oral Implants Res2009，20，10： | 1 |
| 20 | Spinal dural arteriove nous fistulas: experience with endovascular and surgical therapy显示文摘 | Eskandar E N Borges L F Budzik R F Jr | 2002 | J Neurosurg2002，96，2： | 1 |
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