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| 1 | Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes显示文摘Topical administration of phenylethyl resorcinol(PR) has attracted much attention as skin lightening agent with potent anti-tyrosinase activity. Two novel types of elastic carriers were developed to overcome the limitation of PR as topical delivery by increasing the solubility, stability and decreasing skin irritation compared to conventional liposomes. In addition, it also promotes skin penetration of PR to reach deep skin layer at the target site. The lead formulations were obtained from the invasomes containing 1%(w/v) d-limonene mixed with 10%(v/v) absolute ethanol as the skin enhancer, and transfersomes containing 15%(w/w) sodium deoxycholate(SDC) as edge activator. All formulations gave a vesicle size < 500 nm, polydispersity index(PDI) < 0.3, high zeta potential, entrapment efficiency > 50%, and good stability on storage at 30 °C at 75% RH for 4 months. Transfersomes have a lower degree of deformability(6.63%) than invasomes(25.26%). In contrast, the liposomes as rigid vesicles do not show a deformable property. This characteristic affects the skin permeation, and thus, transfersomes with high elastic property provided a significantly higher cumulative amount, steady state flux( J ss) and permeability coefficient( K p) compared to other formulations. However, in vitro PR accumulation in full-thickness newborn pig skin demonstrated that the application of elastic carrier formulations gave significantly higher accumulation than liposomes, and gave anti-tyrosinase activity up to 80%. These results are straightforwardly related to the results of cellular level study. Transfersomes and invasomes showed higher tyrosinase inhibition activity and melanin content reduction when compared to liposomes in B16 melanoma cells. In addition, acute irritation test in rabbits confirmed that these formulations are safe for skin application. Therefore, elastic vesicle carriers have theefficiency to deliver PR into the deep skin in both quantity and effectiveness which are better than conventional liposomes and appropriate for a skin lightening product. | Thanaporn Amnuaikit Tunyaluk Limsuwan Pasarat Khongkow Prapaporna Boonme | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，5： | 5 |
| 2 | Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions 显示文摘 | JUNYAPRASERT VB BOONME P SONGKRO S | 2007 | J Pharm Pharm Sci2007，10，3： | 1 |
| 3 | Characteriza- tion and release kinetics of nicotinamide microemulsion-based gels 显示文摘 | BOONME P SUKSAWAD N SONGKRO S | 2012 | J Cosmet Sci2012，63，6： | 1 |
| 4 | Nanoencapsulation of polyphenols for protective effect against colon-rectal cancer显示文摘 | Santos IS Ponte BM Boonme P | 2013 | Biotechnol Adv2013，31，5： | 1 |
| 5 | Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC 显示文摘 | TEERANACHAIDEEKUL V BOONME P SOUTO E B etal | 2008 | J Controlled Release2008，128，2： | 1 |
| 6 | A BEM-based meshless method for plates on biparametric elastic foundation with internal supports 显示文摘 | Chinnaboon Boonme Katsikadelis John T Chucheepsakul Somchai | 2007 | Computer Methods in Applied Mechanics and Engineering2007，196，33： | 1 |
| 7 | In- fluence of oil content on physieoehemical properties and skin distribution of Nile red-loaded NLC 显示文摘 | Teeranachaideekul V Boonme P Souto EB | 2008 | J Control Release2008，128，2： | 1 |
| 8 | Plates on two-parameter elastic foundations with nonlinear boundary conditions by the boundary element method显示文摘 | BOONME C | 2003 | Computers and Structures2003，81，： | 1 |
| 9 | Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl pahnitate/water/Brij 97 : 1-butanol 显示文摘 | BOONME P KRAUEL K GRAF A | 2006 | AAPS PharmSciTech2006，7，2： | 1 |
| 10 | Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC显示文摘 | Teeranachaideekul V Boonme P Souto E B | 2008 | J Controlled Release2008，128，2： | 1 |
| 11 | Plates on two-parameter elastic foundations with nonlinear boundary conditions by the boundary element method显示文摘 | SOMCHAI C BOONME C | 2003 | Computers and Structures2003，81，： | 1 |
| 12 | Applications of microemulsions in cosmetics显示文摘 | Boonme P | 2007 | J Cosmet Dermatol2007，6，4： | 1 |
| 13 | Junyaprasert, Characterization of microemulsion structures in the pseudoternary phase diagram of isopropyl palmitate/water/Brij 97 : 1 - butanol 显示文摘 | P Boonme K Krauel A Graf | 2006 | AAPS PharmSciTech2006，7，2： | 1 |
| 14 | Liquid and solid self-microemulsifying drug delivery systems for improving the oral bioavailability of andrographolide from a crude extract of Andrographis paniculata 显示文摘 | SERMKAEW N KETJINDA W BOONME P | 2013 | Eur J Pharm Sci2013，50，34： | 1 |
| 15 | Nanoencapsulation of poly- phenols for protective effect against colon-rectal cancer显示文摘 | Santos IS Ponte BM Boonme P | 2012 | Biotech- nol Adv2012，，： | 1 |
| 16 | Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC显示文摘 | Teeranachaideekul V Boonme P Souto EB | 2008 | J Controlled Release2008，128，2： | 1 |
| 17 | Evaluation of cross-linked chitosan microparticles containing metronidazole for periodontitis treatment 显示文摘 | Pichayakorn W Boonme P | 2013 | Mater Sci Eng C Mater Biol Appl2013，33，3： | 1 |
| 18 | Nanoencapsulation of polyphenols for protective effect against colon–rectal cancer显示文摘 | Isis S. Santos Bruno M. Ponte Prapaporn Boonme Amélia M. Silva Eliana B. Souto | 2013 | Biotechnology Advances2013，，5： | 1 |
| 19 | Applications of microemulsions显示文摘 | Boonme P | | 0，，4： | 1 |
| 20 | Microemulsion-based hydrogels of itraconazole:Evaluation of characteristics and stability显示文摘Itraconazole (ITZ) is a broad spectrum triazole antifungal drug and commercially available as oral forms. However, effective topical forms are interesting to avoid systemic adverse effects,to directly deliver antifungal drugs to the target sites and to enhance patient compliance (1)Microemulsion-based hydrogel (MBH), a semisolid form of microemulsion (ME), is one of novel formulations practically used as topical drug carriers [2]. | Prapaporn Boonme Jarika Kaewbanjong Sugitta Sangduangyang Suttipa Suksawat Veerawat Teeranachaideekul | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 0 |
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