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1篇 您的检索式：作者名="Bongjun Kim"

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		题名	作者	年代	出处	被引量
	1	S100A4 released from highly bone-metastatic breast cancer cells plays a critical role in osteolysis显示文摘Bone destruction induced by breast cancer metastasis causes severe complications,including death,in breast cancer patients.Communication between cancer cells and skeletal cells in metastatic bone microenvironments is a principal element that drives tumor progression and osteolysis.Tumor-derived factors play fundamental roles in this form of communication.To identify soluble factors released from cancer cells in bone metastasis,we established a highly bone-metastatic subline of MDA-MB-231 breast cancer cells.This subline(mtMDA)showed a markedly elevated ability to secrete S100A4 protein,which directly stimulated osteoclast formation via surface receptor RAGE.Recombinant S100A4 stimulated osteoclastogenesis in vitro and bone loss in vivo.Conditioned medium from mtMDA cells in which S100A4 was knocked down had a reduced ability to stimulate osteoclasts.Furthermore,the S100A4 knockdown cells elicited less bone destruction in mice than the control knockdown cells.In addition,administration of an anti-S100A4 monoclonal antibody(mAb)that we developed attenuated the stimulation of osteoclastogenesis and bone loss by mtMDA in mice.Taken together,our results suggest that S100A4 released from breast cancer cells is an important player in the osteolysis caused by breast cancer bone metastasis.	Haemin Kim Bongjun Kim Sang Il Kim Hyung Joon Kim Brian YRyu Junho Chung Zang Hee Lee Hong-Hee Kim	2019	Bone Research2019，7，4：	2

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