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| 1 | An AIEgen/graphene oxide nanocomposite(AIEgen@GO)-based two-stage“turn-on”nucleic acid biosensor for rapid detection of SARS-CoV-2 viral sequence显示文摘The ongoing outbreak of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)pandemic has posed significant challenges in early viral diagnosis.Hence,it is urgently desirable to develop a rapid,inexpensive,and sensitive method to aid point-of-care SARS-CoV-2 detection.In this work,we report a highly sequence-specific biosensor based on nanocomposites with aggregationinduced emission luminogens(AIEgen)-labeled oligonucleotide probes on graphene oxide nanosheets(AIEgen@GO)for one step-detection of SARS-CoV-2-specific nucleic acid sequences(Orf1ab or N genes).A dual“turn-on”mechanism based on AIEgen@GO was established for viral nucleic acids detection.Here,the first-stage fluorescence recovery was due to dissociation of the AIEgen from GO surface in the presence of target viral nucleic acid,and the second-stage enhancement of AIEbased fluorescent signal was due to the formation of a nucleic acid duplex to restrict the intramolecular rotation of the AIEgen.Furthermore,the feasibility of our platform for diagnostic application was demonstrated by detecting SARS-CoV-2 virus plasmids containing both Orf1ab and N genes with rapid detection around 1 h and good sensitivity at pM level without amplification.Our platform shows great promise in assisting the initial rapid detection of the SARS-CoV-2 nucleic acid sequence before utilizing quantitative reverse transcription-polymerase chain reaction for second confirmation. | Qin Zhang Bohan Yin Jianhua Hao Linjie Ma Yingying Huang Xueying Shao Chuanqi Li Zhiqin Chu Changqing Yi Siu Hong Dexter Wong Mo Yang | 2023 | Aggregate2023，4，1： | 0 |
| 2 | Plastic Crystal Neopentyl Glycol/Multiwall Carbon Nanotubes Composites for Highly Efficient Barocaloric Refrigeration System显示文摘Plastic crystal neopentyl glycol(NPG)exhibits colossal barocaloric effect with high entropy changes.However,their application is restricted in several aspects,such as low thermal conductivity,substantial supercooling effect,and poor springback properties.In this work,multi-walled carbon nanotubes(MWCNTs)with ultra-high thermal conductivity and high mechanical strength were selected for performance enhancement of NPG.The optimal mixing ratio was determined to be NPG with 3 wt%MWCNTs composites,which showed a 6K reduction in supercooling without affecting the phase change enthalpy.Subsequently,comprehensive performance of the composites with optimal mixing ratio was compared with pure NPG At 40 MPa,390J·K^(-1)·kg^(-1)change in entropy and 9.9 K change in temperature were observed.Furthermore,the minimum driving pressure required to achieve reversible barocaloric effect was reduced by 19.2%.In addition,the thermal conductivity of the composite was increased by approximately 28%,significantly reducing the heat exchange time during a barocaloric refrigeration cycle.More importantly,ultra-high pressure release rate resulted in a73.7%reduction in the springback time of the composites,offering new opportunities for the recovery of expansion work. | DAI Zhaofeng SHE Xiaohui SHAO Bohan YIN Ershuai DING Yulong LI Yongliang ZHANG Xiaosong ZHAO Dongliang | 2024 | Journal of Thermal Science2024，33，1： | 0 |
| 3 | An energy-efficient dynamically reconfigurable cryptographic engine with improved power/EM-side-channel-attack resistance显示文摘Dear editor,With the prevalence of Internet of things(IoT)applications,energy efficiency is an essential feature for cryptographic engines besides the high security under resource constraints[1].In the meanwhile,security protocols normally involve various types of cryptographic algorithms,and both protocols and cryptographic algorithms are undergoing rapid evolution[2],posing significant flexibility challenges for cryptographic engines.Application specific integrated circuit accelerators have significant advantages in energy efficiency but cannot change their functionality after fabrication.General purpose processor(GPP)-based cryptographic engines are highly flexible to accommodate different algorithms. | Chenchen DENG Min ZHU Jinjiang YANG Youyu WU Jiaji HE Bohan YANG Jianfeng ZHU Shouyi YIN Shaojun WEI Leibo LIU | 2022 | Science China(Information Sciences)2022，65，4： | 0 |
| 4 | Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy显示文摘Adoptive T-cell therapy(ACT)is a promising therapeutic approach based on the concept of potent T-cell mediated immunity against the tumor.The outcome of antigen-specific T-cells responses relies on the interaction between T-cells and antigen-presenting cells,which provides signals for generating different T-cell phenotypes with different roles in tumor removal.However,such interaction is often not optimal in vivo and results in low therapeutic efficacy.To reach the full potential of the T-cell response,current research put effort into developing dynamic biomaterials as artificial antigen-presenting cells to study and regulate the T-cell activity for controlling T-cell fate.In this perspective,we provide(1)an overview of ACT and general T-cells behaviors,(2)explore the insight on how biomaterials can be used for studying and regulating T-cell behaviors,(3)and discuss conceptual gaps in knowledge for biomaterials-based immunotherapy. | Wai Ki Wong Bohan Yin Anel Rakhmatullina Jingying Zhou Siu Hong Dexter Wong | 2021 | Engineered Regeneration2021，2，1： | 0 |
| 5 | In vivo bioorthogonal labeling of rare-earth doped nanoparticles for improved NIR-II tumor imaging by extracellular vesiclemediated targeting显示文摘The development of efficient contrast agents for tumor-targeted imaging remains a critical challenge in the clinic.Herein,we proposed a tumor-derived extracellular vesicle(EV)-mediated targeting approach to improve in vivo tumor imaging using ternary downconversion nanoparticles(DCNPs)with strong near infrared II(NIR-II)luminescence at 1,525 nm.The EVs were metabolically engineered with azide group,followed by in vivo labeling of DCNPs through copper-free click chemistry.By taking advantage of the homologous targeting property of tumor derived EVs,remarkable improvement in the tumor accumulation(6.5%injection dose(ID)/g)was achieved in the subcutaneous colorectal cancer model when compared to that of individual DCNPs via passive targeting(1.1%ID/g).Importantly,such bioorthogonal labeling significantly increased NIR-II luminescence signals and prolonged the retention at tumor sites.Our work demonstrates the great potential of EVs-mediated bioorthogonal approach for in vivo labeling of NIR-II optical probes,which provides a robust tool for tumor-specific imaging and targeted therapy. | Hui Li Yanfeng Zhong Shumin Wang Menglei Zha Wenxing Gu Guoyong Liu Bohan Wang Zhendong Yu Yu Wang Kai Li Yuxin Yin Jing Mu Xiaoyuan Chen | 2023 | Nano Research2023，16，2： | 0 |
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