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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Metaphor in Idiom Comprehension显示文摘 | Raymond W. Gibbs Josephine M. Bogdanovich Jeffrey R. Sykes Dale J. Barr | 1997 | Journal of Memory and Language1997，，2： | 2 |
| 3 | A real-time PCR assay for the specific identification of serotype 0:9 of Yersinia enterocolitica显示文摘 | JACOBSEN N R BOGDANOVICH T SKURNIK M | 2005 | Journal of Microbiological Methods2005，63，2： | 1 |
| 4 | Three-dimensional variation impact contact analysis of composite bars and plates 显示文摘 | Yushanov S P | 2000 | Composites:Part A2000，31，： | 1 |
| 5 | Functional im- provement of dystrophic muscle by myostatin blockade显示文摘 | Bogdanovich S Krag TO Barton ER | 2002 | Nature2002，420，： | 1 |
| 6 | Functional im- provement of dystrophic functional improvement of dystrophic muscle by myostat显示文摘 | Bogdanovich S Ragtob K Barton E R | 2002 | Nature2002，420，： | 1 |
| 7 | Functional improvement of dystrophic muscle by myostatin blockade显示文摘 | Bogdanovich S Krag T O Barton E R | 2002 | Nature2002，420，6914： | 1 |
| 8 | Inhibitionof choroidal and corneal pathological neovascularizationby Plgfl-de gene transfer 显示文摘 | Tarallo V Bogdanovich S Hirano Y | 2012 | Invest Ophthalmol VisSci2012，53，13： | 1 |
| 9 | Fatigue tensile behavior of carbon/epoxy composite reinforced with non-crimp 3D orthogonal woven fabric显示文摘 | Karahan M Lomov S V Bogdanovich A E | 2011 | Composites Science and Technology2011，71，16： | 1 |
| 10 | Myostatin propeptide--mediated amelioration of dystrophic pathophysiology显示文摘 | Bogdanovich S Perkins KJ Krag TO Whittemore LA Khurana TS | 2005 | FASEB J2005，19，： | 1 |
| 11 | On the understanding of tensile elastic and strength properties of integrally woven 3D carbon composites 显示文摘 | Dickinson L C Bogdanovich A E | 2002 | American Society of Mechanical Engineers Textile Engineering Division2002，11，2： | 1 |
| 12 | Functional improvement of dystrophic muscle by myostatin blockade显示文摘 | Bogdanovich S Krag TO Barton ER | 2002 | Nature2002，420，6914： | 1 |
| 13 | Functional improvement of dystrophic muscle by myostatin blockade显示文摘 | BOGDANOVICH S KRAG T O B BARTON E R | 2002 | Nature2002，420，6914： | 1 |
| 14 | Metal-polymer nanocomposites produced by the melt-compounding interaction of an aliphatic polyamide with metal particles显示文摘 | Pesetskii S.S Jurkowski B Krivoguz Y.M Davydov A.A. Bogdanovich S.P | | 0，，03： | 1 |
| 15 | PME-1, an extended-spectrum β-1actamase identified in Pseudomonas aeruginosa 显示文摘 | TIAN G B ADAMS-HADUCH J M BOGDANOVICH T | 2011 | Antimicrob Agents Chemother2011，55，6： | 1 |
| 16 | Fabrication and mechanical characterization of carbon nanotube yarns,3-Dbraids,and their composites显示文摘 | Bogdanovich A Bradford P Mungalov D | 2007 | Sample Journal2007，43，1： | 1 |
| 17 | Metaphor in Idiom Comprehension显示文摘 | GIBBS R BOGDANOVICH J SYKES J | 1997 | journal of Memory and Language1997，，37： | 1 |
| 18 | Antistaphylococcal activity of ceftobiprole,a new broad-spectrum cephalosporin显示文摘 | BOGDANOVICH T EDNIE LM SHAPIRO S | 2005 | Antimicrob Agents Chemother2005，49，10： | 1 |
| 19 | Three-Dimensional analysis of thick composite plates with multiple layers显示文摘 | Bogdanovich A E Deepak B P | 1997 | Composite1997，，28： | 1 |
| 20 | Molecular epidemiology of carbapenem-nonsusceptible Acinetobacter baumannii in the United States显示文摘 | Adams-Haduch JM Onuoha EO Bogdanovich T | 2011 | J Clin Microbiol2011，49，11： | 1 |
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