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| 1 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 2 | Comparison of caudal and intravenous clonidine in the prevention of agitation after sevoflurane in children 显示文摘 | Bock M Kunz P Chreckenberger R | 2002 | Br J Anaesthesia2002，88，6： | 1 |
| 3 | Integration of endocytosis and signal transduction by lipoprotein receptors 显示文摘 | Bock HH Herz J | 2003 | Sci STKE2003，176，： | 1 |
| 4 | The modular architecture of a new family of growth regulation related to connective tissue growth factor显示文摘 | | 1993 | FEBS Lett1993，327，2： | 1 |
| 5 | Anatomy of Apparent Seasonal Variations from GPS Derived Site Position Time Series 显示文摘 | DONG D FANG P BOCK Y | 2002 | JGR2002，107，4： | 1 |
| 6 | Integrated satellite interferometry: troposphere noise, GPS estimates, and implications for synthetic aperture radar products 显示文摘 | Williams S Bock Y Fang P | 1998 | Journal of Geophysical Research1998，103，27： | 1 |
| 7 | Comparison of caudal and intravenous elonidine in the prevention of agitation after sevoflurane in children显示文摘 | Bock M Kunz P Schreckenberger R | 2002 | Br J Anaesth2002，88，6： | 1 |
| 8 | Anatomy of Apparent Seasonal Variations from GPS-derived Site Position Time Series显示文摘 | Dong D Fang P Bock Y | 2002 | Journal of Geophysical Research2002，107，4： | 1 |
| 9 | Quality of life of patients with keloid and hypertrophic scarring 显示文摘 | Bock O Schmid-Ott G Malewski P | 2006 | Arch Dermatol Res2006，297，10： | 1 |
| 10 | Instantaneous ge- odetic positioning at medium distances with the Global Posi tioning System显示文摘 | Bock Y R Nikolaidis P J De Jonge | 2000 | Journal of Geophysical Research2000，105，28： | 1 |
| 11 | Real-time optimization and nonlinear model predictive control of processes governed by differential-algebraic equations显示文摘 | Diehl M Bock H G Schloder J P | 2002 | Journal of Process Control2002，12，4： | 1 |
| 12 | Anatomy of apparent seasonal variations from GPS derived site position time se- ries 显示文摘 | Dong D N Fang P Bock Y | 2002 | Journal of Geophysical Research2002，107，4： | 1 |
| 13 | Anatomy of Apparent Sea sonal Variations from GPS - Derived Position Site Time Series显示文摘 | Dong D Fang P Bock Y | 2002 | Journal of Geophysical Research2002，107，4： | 1 |
| 14 | Scarf截骨治疗拇外翻的中长期随访结果显示文摘Scarf截骨治疗拇外翻畸形的远期效果和复发率研究甚少。作者对108例行Scarf截骨的拇外翻患者(115足)进行研究,平均随访124个月。结果发现,AOFAS平均评分由术前的57分提高至95分,影像学测量(拇外翻角、跖骨间角和和籽骨位置)显著改善(P〈0.05),复发率为30%。 | Bock P Kluger R Kristen K H 李军 | 2015 | 临床骨科杂志2015，18，6： | 1 |
| 15 | Matrix comprehensive in-house validation and robustness check of a confirmatory method for the determination of four nitrofuran metabolites in poultry muscle and shrimp by LC-MS/MS显示文摘 | Bock C Gowik P Stachel C | 2007 | J Chromatogr B2007，856，： | 1 |
| 16 | Anatomy of apparent seasonal variations from GPS derived site position time series显示文摘 | Dong D Fang P Bock Y | 2002 | JGR2002，107，4： | 1 |
| 17 | Lone pair functionality in divalent lead compounds显示文摘 | Shimoni-Livny L Glusker J P Bock C W | 1998 | Inorg Chem1998，37，： | 1 |
| 18 | Plant disease severity estimated visually,by digital photography and image analysis,and by hyperspectral imaging显示文摘 | Bock C H Poole G H Parker P E | 2010 | Critical Reviews in Plant Sciences2010，29，2： | 1 |
| 19 | Hallux valgus and cartilage degeneration in the first metatarsophalangeal joint显示文摘 | Bock P Kristen KH Kr?ner A | 2004 | J Bone Joint Surg Br2004，86，5： | 1 |
| 20 | et al, Thrombin-thrombomodulin Activation of Protein C Facilitates the Activation of Progelatinase A显示文摘 | Pekovich S R Bock P E Hoover R L | 2001 | FEBS Lett2001，494，12： | 1 |
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