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55篇 您的检索式:作者名="Bochev"
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1Secretion of immunoregulatory cytokines by mesenchymal stem cells显示文摘According to the minimal criteria of the International Society of Cellular Therapy, mesenchymal stem cells(MSCs) are a population of undifferentiated cells defined by their ability to adhere to plastic surfaces when cultured under standard conditions, express a certain panel of phenotypic markers and can differentiate into osteogenic, chondrogenic and adipogenic lineages when cultured in specific inducing media. In parallel with their major role as undifferentiated cell reserves, MSCs have immunomodulatory functions which are exerted by direct cell-to-cell contacts, secretion of cytokines and/or by a combination of both mechanisms. There are no convincing data about a principal difference in the profile of cytokines secreted by MSCs isolated from different tissue sources, although some papers report some quantitative but not qualitative differences in cytokine secretion. The present review focuses on the basic cytokines secreted by MSCs as described in the literature by which the MSCs exert immunodulatory effects. It should be pointed out that MSCs themselves are objects of cytokine regulation. Hypothetical mechanisms by which the MSCs exert their immunoregulatory effects are also discussed in this review. These mechanisms may either influence the target immune cells directly or indirectly by affecting the activities of predominantly dendritic cells. Chemokines are also discussed as participants in this process by recruiting cells of the immune systems and thus making them targets of immunosuppression. This review aims to present and discuss the published data and the personal experience of the authors regarding cytokines secreted by MSCs and their effects on the cells of the immune system.Dobroslav Kyurkchiev Ivan Bochev Ekaterina Ivanova-Todorova Milena Mourdjeva Tsvetelina Oreshkova Kalina Belemezova Stanimir Kyurkchiev 2014World Journal of Stem Cells2014,6,5:20
2Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome显示文摘Margarita Alexandrova Petyo Bochev Vanya Markova Blagovest Bechev Marina Popova Maya Danovska Virginia Simeonova 2003Journal of Clinical Neuroscience2003,,5:2
3Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells显示文摘Ivanova-Todorova E Bochev I Mourdjeva M 2009Immunol Lett2009,126,12:1
4Aecuary of least squares methods for the Navier Stokes equations显示文摘Bochev P B Gunzburger M D 1993Comput Fluid1993,22,54:1
5Least-squares finite element methods for first-order elliptic systems显示文摘Bochev P B 2004International Journalof Numerical Analysis and Modeling2004,1,1:1
6On least-squares finite element methods for the Poisson equation and theirconnection to the Dirichlet and Kelvin principles显示文摘Bochev P Gunzburger M 2005SIAM Journal on Numerical Analysis2005,43,1:1
7Adipose tissue- derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells显示文摘Ivanova-Todorova E Bochev I Mourdjeva M 2009Immunol Lett2009,126,12:1
8Dynamics of free radical processes in acute ischemicstroke: influence on neurological status and outcome 显示文摘Alexandrova M Bochev P Markova V 2004Clin Neurosci2004,11,:1
9Seed nitrogen content and its relation to some M metabolism elements in lines by hybridization显示文摘Tsanev V Popova E Bochev B 1993Cereal Reseach Communication1993,21,23:1
10Brain metastases de?tectability of routine whole body 18F-FDG PET and low dose CT scanning in 2502 asymptomatic patients with solid extracranial tumors显示文摘Bochev P Klisarova A Kaprelyan A 2012HellJ Nucl Med2012,15,2:1
11Reduced extracellular phagocyte ox- idative activity, antioxidant level changes and increased oxidative damage in healthy human blood as a function of age 显示文摘Alexandrova ML Bochev PG 2009Age (Dordr)2009,31,2:1
12Dynamics of free radical processes in acute ischemic stroke:influence on neurological status and out come显示文摘Alexandrova M Bochev P Markova V 0,,05:1
13Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome显示文摘Margarita Alexandrova Petyo Bochev Vanya Markova Blagovest Bechev Marina Popova Maya Danovska Virginia Simeonova 2003Journal of Clinical Neuroscience2003,,5:1
14Stabili- zation of low-order mixed finite elements for the stokes equations显示文摘Bochev P B Dohrmann C R Gunzburger M D 2006SIAM J Numer Anal2006,44,:1
15Stabilization of low-order mixed finite elements for the stokes equations显示文摘Bochev P B Dohrmann C R Gunzburger M D 2006SIAM J Numer Anal2006,44,:1
16Stabilization of low-order mixed finite elements for the Stokes equations显示文摘Bochev P B Dohrmann C R Gunzburger M D 2006SIAM Journal on Numerical Analysis2006,44,1:1
17Reduced extracellular phagocyte oxidative activity, antioxidant level changes and increased oxida- tive damage in healthy human blood as a function of age 显示文摘Alexandrova ML Bochev PG 2009Age (Dordr)2009,31,2:1
18Stabilization of low-order mixed finite elements for the Stokes equations 显示文摘Bochev P Dohnmann C Gunzburger M 2005SIAM J Numer Anal2005,44,1:1
19Oxidative stress during the chronic phase after stroke 显示文摘Alexandrova ML Bochev PG 2005Free Rad Biol Med2005,39,3:1
20Adipose tis- sue - derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow - de- rived mesenchymal stem cells 显示文摘Ivanova - Todorova E Bochev I Mourdjeva M 2009Immunology letters2009,126,12:1
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