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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | Mindfulness and self-compassion:Exploring pathways to adolescent emotional well-being显示文摘 | Bluth K Blanton P W | 2014 | Journal of Child and Family Studies2014，23，7： | 1 |
| 3 | The influence of self-compassion on emotional well-being among early and older adolescent males and females显示文摘 | Bluth K Blanton P W | 2015 | The Journal of Positive Psychology2015，10，3： | 1 |
| 4 | The influence of self-compassion on emotional well-being among early and older adolescent males and females显示文摘 | Bluth K Blanton P W | 2015 | J Posit Psychol2015，10，3： | 1 |
| 5 | Cytokine-induced sickness behavior显示文摘 | Kelley K W Bluthe R M Dantzer R | 2003 | Brain Behav Immun2003，17，1： | 1 |
| 6 | TNFalpha-induced sickness behavior in mice with functional 55 kD TNF receptors is blocked by central IGF-I显示文摘 | Palin K Bluthe R M McCusker R H | 2007 | J Neuroimmunol2007，187，： | 1 |
| 7 | Effects of insulin like growth factor-I on cytokineinduced sickness behavior in mice显示文摘 | Bluthe R M Kelley K W Dantzer R | 2006 | Brain Behav Immun2006，20，： | 1 |
| 8 | Androgen dependent vasopressinergic neurotransmission attenuates interleukin-1-induced sick-nessbehavior显示文摘 | Dantzer R Bluthe R M Kelley K W | 1991 | Brain Res1991，557，： | 1 |
| 9 | Parent/child transactional processes pre- dictive of resilience or vulnerability to 'substance abuse disor- ders'显示文摘 | Kumpfer K L Bluth B | 2004 | Substance Use &Misuse2004，39，5： | 1 |
| 10 | Sickness behavior as a new target for drug development显示文摘 | Kent S Bluthe R M Kelly K W | 1992 | Trends in Pharmacological Sciences1992，131，1： | 1 |
| 11 | Mindfulness and Self-Compassion:Exploring Pathways to Adolescent Emotional Well-Being显示文摘 | Bluth K Blanton P W | 2012 | Journal of Child and Family Studies2012，，： | 1 |
| 12 | Sickness Behavior As a New Target for Drug Development显示文摘 | Kent S Bluthe R M Kelley K W | 1992 | Trends Pharmacol Sci1992，13，1： | 1 |
| 13 | Sickness behavior as a new target for drug development 显示文摘 | Bluthé R-M Kelly K W | 1992 | Trends Pharmacol Sci1992，13，： | 1 |
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