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| 1 | TNF-α Induces Transient Resistance to Fas-Induced Apoptosis in Eosinophilic Acute Myeloid Leukemia Cells显示文摘Tumor necrosis factor α (TNF-α) has been recognized as an activator of nuclear factor κB (NF-κB), a factor implicated in the protection of many cell types from apoptosis. We and others have presented evidence to suggest that Fas-induced apoptosis may be an important aspect of the resolution of inflammation, and that delayed resolution of inflammation may be directly associated with NF-κB-dependent resistance to Fas. Because TNF-α activates NF-κB in many cell types including inflammatory cells such as eosinophils, we examined effects of TNF-α signaling on the Fas-mediated killing of an eosinophilic cell line AML14. While agonist anti-Fas (CH11) treatment induced apoptosis in AML14 cells, no significant cell death occurred in response to TNF-α alone. Electrophoretic mobility shift assay (EMSA) revealed that TNF-α induced NF-κB transactivation in AML14 cells in a time- and dose-dependent fashion, and subsequent supershift assays indicated that the translocated NF-κB was the heterodimer p65 (RelA)/p50. Pre-treatment of cells with TNF-α dramatically decreased the CH11-induced cell death in a transient fashion, accompanied by suppression of activation of caspase-8 and caspase-3 activation. Inhibition of NF-κB transactivation by inhibitors, BAY 11-7085 and parthenolide, reversed the suppression of Fas-mediated apoptosis by TNF-α. Furthermore, TNF-α up-regulated X-linked inhibitor of apoptosis protein (XIAP) transiently and XIAP levels were correlated with the temporal pattern of TNF-α protection against Fas-mediated apoptosis. This finding suggested that TNF-α may contribute to the prolonged survival of inflammatory cells by suppression of Fas-mediated apoptosis, the process involved with NF-κB transactivation,anti-apoptotic XIAP up-regulation and caspase | Yimin Qin Sogyong Auh Lyubov Blokh Catherine Long Isabelle Gagnon Kimm J. Hamann | 2007 | Cellular & Molecular Immunology2007，4，1： | 19 |
| 2 | Roots of continuous pieeewise monotone maps of an interval显示文摘 | Blokh A Coven E Misiurewicz M | 1991 | Acta Math Univ Co- menian1991，60，： | 1 |
| 3 | Measurable dynamics of S_unimodal maps of the interval显示文摘 | Lyubich M Yu | 1991 | Ann Sci cole Norm Sup(4)1991，24，4： | 1 |
| 4 | Roots of continuous piecewise monotone maps of an interval显示文摘 | Blokh A Coven E Misiurewicz M | | 0，，： | 1 |
| 5 | Sets that force recurrence 显示文摘 | BLOKH A FIELDSTEEL A | 2000 | Proc Amer Math Soc2000，130，12： | 1 |
| 6 | Heat transfer in furnaces of high-power boilers 显示文摘 | Blokh A G Zhuravlev Yu A Gorb E I | 1993 | Heat Transfer Research1993，25，3： | 1 |
| 7 | The spectral decomposition for one-dimen- sional maps 显示文摘 | BLOKH A | 1995 | Dynamics Reported1995，4，： | 1 |
| 8 | Metastatic choriocarcinoma in a middle-aged man presenting as a right thigh mass with venous thrombosis:a case report显示文摘 | Blokh I Oiseth SJ Fuks J | 2003 | Med Oncol2003，20，2： | 1 |
| 9 | The space of ω - limit sets of continuous map of the interval 显示文摘 | Blokh A Bruekner A M Humke P D | 1996 | Transactions of the American Mathematical Society1996，，4： | 1 |
| 10 | Crosslinking of Butadiene-Nitrile Rubber by Hydrogen Sulfide in the Presence of Sulfur显示文摘 | Nosnikov A F Blokh G A Lazurovich T Y | 1968 | Khimicheskaya Tekhnologiya1968，，7： | 1 |
| 11 | Vulcanization of Filled Rubber Mixtures Based on Butadiene-Nitrile Rubbers by Hydrogen Sulfide in the Presence of Organic Peroxides or Sulfur Dioxide Introduced on Zeolites显示文摘 | Nosnikov A F Blokh G A | 1967 | Khimicheskaya Tekhnologiya1967，，9： | 1 |
| 12 | New order for periodic orbits of interval maps显示文摘 | BLOKH A M M | 1997 | Ergod Th & Dynam Sys1997，17，： | 1 |
| 13 | The set of all iterates is nowhere dense in C(,)显示文摘 | BLOKH A M | 1992 | Trans Amer Math Soc1992，333，： | 1 |
| 14 | Phylogenetic characterization of Clostridium related segmented filamentous bacteria in mice based on 16S ribosomal RNA analysis显示文摘 | SNEL J BLOKH J KENGENH M P | 1994 | Systemat Appl Microbial1994，17，2： | 1 |
| 15 | Comparison of 16S rRNA sequences of segmented filamentous bacteria isolated from mice, rats, and chickens and proposal of ' Candidatus Arthomitus' 显示文摘 | SNEL J HEINEN P P BLOKH J ct al | 1995 | Int J Syst Bacteriol1995，45，4： | 1 |
| 16 | Trees with snowflkes and zero entropy aps显示文摘 | BLOKH A M | 1994 | Topology1994，33，： | 1 |
| 17 | Metastatic ehorinearcinoma in a mid- die-aged man presenting as aright thigh mass with venous thrombosis: a case report显示文摘 | Blokh I Oiseth SJ Fuks J | 2003 | Med Onco12003，20，2： | 1 |
| 18 | Heat transfer in fumaces of high - power boilers显示文摘 | BLOKH A G | 1993 | Heat Transfer Research1993，25，3： | 1 |
| 19 | Trees with snowflakes and zero entropy maps 显示文摘 | BLOKH A M | 1994 | Topology1994，33，： | 1 |
| 20 | Recurrent critical points and typical limit sets for conformal measures 显示文摘 | Blokh A M Mayer J C Oversteegen L G | 2000 | Topology and Its Applications2000，108，： | 1 |
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