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55篇 您的检索式:作者名="Blits B"
    题名 作者 年代 出处 被引量
1Intercostal nerve implants t ransduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function显示文摘Blits B Dijkhuizen PA Boer GJ 2000Exp Neurol2000,164,1:2
2Lentivirus介导神经营养因子-3促进脊髓损伤大鼠功能恢复显示文摘目的探讨Lentivirus介导分泌神经营养因子-3(NT-3)直接体内转基因治疗大鼠脊髓损伤作用和机制。方法将28只Wistar大鼠在T10水平制成半横断损伤模型,随机分为体内转基因治疗组和损伤对照组,每组14只;用携带NT-3和绿色荧光蛋白(GFP)的Lentivirus对大鼠行直接体内转基因治疗;荧光显微镜观察体内转基因表达,后肢运动功能评分法(BBB评分)检测大鼠后肢功能恢复情况。结果用荧光显微镜检测到损伤脊髓内有较多的持续表达转基因的细胞;BBB评分结果显示,从伤后第4周开始,实验组大鼠后肢功能较对照组明显恢复(P<0.01),至第10周时,实验组和对照组BBB分差增大,达3.3分。结论Lentivirus是一种有效的转基因载体,由Lentivirus介导分泌NT-3的直接体内转基因治疗能够明显促进损伤脊髓的功能恢复。蔡培强 汤逊 林月秋 Oudega Mart 徐林 Blits B 阳运康 M.OUDEGA 2005中华创伤杂志2005,21,7:2
3Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes显示文摘Harper MM Grozdanic SD Blits B Kuehn MH Zamzow D Buss JE 2011Invest Optuhalmol Vis Sci2011,52,7:1
4Intravitreal injection of adeno-associated viral vectors results in the transduction of different types of retinal neurons in neonatal and adult rats:a comparison with lentiviral vectors显示文摘Harvey AR Kamphuis W Eggers R Symons NA Blits B Niclou S et ol 2002Mol Cell Neurosci2002,21,1:1
5Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function显示文摘BLITS B DIJKHUIZEN P A BOER G J 2000Exp Neurol2000,164,1:1
6Transplantation of BDNF- secreting mesenehymal stem eells provides neuroproteetion in chronically hypertensive rat eyes显示文摘Harper MM Grozdanie SD Blits B 2011Invest Ophthalmol Vis Sei2011,52,7:1
7Adeno-associated viral vectormediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limc function显示文摘Blits B Oudega M Boer GJ 2003Neurosci2003,118,1:1
8Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function显示文摘Blits B Dijkhuizen PA Boer GJ 2000Exp Neurol2000,164,1:1
9Intercostal nerve implants transduced with andenoviral vector encoding neurotrophin - 3 promote growth of injured rat corticospinal tract fibers and improve hind limb function显示文摘Blits B Dijkhuizen PA Boer GJ 2000Exp Neurol2000,164,1:1
10Adeno-aasociated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind~limb function显示文摘Blits B Oudega M Boer GJ 2003Neuroscience2003,118,:1
11Amelioration of chronic neuropathic pain after partial nerve injury by adenoassociated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord 显示文摘Eaton MJ Blits B Rultenberg MJ 2002Gene Ther2002,9,20:1
12Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function显示文摘 Dijkhuizen P A Boer G J 2000Exp Neurol2000,164,:1
13Intercostals nerve implants transduced with anadenoviral vector encoding neurotrophin -3 promoter regrowth of injured rat corticospinal trac fibers and improve hind limd function 显示文摘Blits B Dijkhuizen PA Boer GJ 2000Exp Neurol2000,164,1:1
14Amelioration of chronic neuropathic pain after partial nerve injury by adeno-associated viral (AAV) vector-mediated over-expression of BDNF in the rat spinal cord显示文摘Eaton MJ Blits B Ruitenberg MJ 2002Gene Therapy2002,9,20:1
15Direct gene therapy for repair of the spinal cord显示文摘Blits B Bunge MB 2006J Neurotrauma2006,5,34:1
16Direct gene therapy for repair of the spinal cord显示文摘 Bunge MB 2006J Neurotrauma2006,23,34:1
17Intercostal nerve implants transduced with andenoviral vector encoding neurotrophin - 3 promote growth of injured rat corticospinal tract fibers and improve hind limb function显示文摘Blits B Dijkhuizen PA Boer GJ 2000Exp Neurol2000,164,1:1
18Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor显示文摘Blits B Carlstedt TP Ruitenberg MJ 2004Exp Neurol2004,189,2:1
19Adeno-associated viral vector-mediated neurotrophin gene transfer in the injured adult rat spinal cord improves hind-limb function显示文摘Blits B Oudega M Boer GJ Bartlett Bunge M Verhaagen J 0,,:1
20Early necrosis and apoptosis of Schwann cells transplanted into the injured rat spinal cord 显示文摘Hill C E Hurtado A Blits B 2007Eur J Neurosci2007,26,6:1
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