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| 1 | An iterative criterion for H-Matrices显示文摘 | Li Bishan | 1998 | Linear Algebra and Its Applications1998，，1： | 1 |
| 2 | An Iterative Criterion for H-Matrices显示文摘 | Li Bishan Li Lei | 1998 | Linear Algebra Appl1998，271，： | 1 |
| 3 | Doubly diagonally dominant matrices显示文摘 | Li Bishan Tsatsomeros M J | 1997 | Linear Algebra Appl1997，261，： | 1 |
| 4 | Doubly diagonally dominant matrices 显示文摘 | Bishan Li Tsatsomeros M J | 1997 | Linear Algebra Appl1997，261，： | 1 |
| 5 | Doubly Diagonally Dominant Matrices显示文摘 | Li Bishan Tsatsomeros M J | 1997 | Linear Algebra and Its Applications1997，261，123： | 1 |
| 6 | An iterative criterion for H-matrices显示文摘 | Lei Li Masunori Harada | 1998 | Linear Algebra and Its Applications1998，271，： | 1 |
| 7 | Double diagonally dominant matrices显示文摘 | Li Bishan Tsatsonmeros M J | 1997 | Linear Algrbra Appl1997，261，13： | 1 |
| 8 | Glutamine metabolic microenvironment drives M2 macrophage polarization tomediate trastuzumab resistance in HER2-positive gastric cancer显示文摘Background:Trastuzumab is a first-line targeted therapy for human epidermal growth factor receptor-2(HER2)-positive gastric cancer.However,the inevitable occurrence of acquired trastuzumab resistance limits the drug benefit,and there is currently no effective reversal measure.Existing researches on the mechanism of trastuzumab resistance mainly focused on tumor cells themselves,while the understanding of the mechanisms of environment-mediated drug resistance is relatively lacking.This study aimed to further explore the mechanisms of trastuzumab resistance to identify strategies to promote survival in these patients.Methods:Trastuzumab-sensitive and trastuzumab-resistant HER2-positive tumor tissues and cells were collected for transcriptome sequencing.Bioinformatics were used to analyze cell subtypes,metabolic pathways,and molecular signaling pathways.Changes in microenvironmental indicators(such as macrophage,angiogenesis,and metabolism)were verified by immunofluorescence(IF)and immunohistochemical(IHC)analyses.Finally,a multi-scale agent-based model(ABM)was constructed.The effects of combination treatment were further validated in nude mice to verify these effects predicted by the ABM.Results:Based on transcriptome sequencing,molecular biology,and in vivo experiments,we found that the level of glutamine metabolism in trastuzumabresistant HER2-positive cells was increased,and glutaminase 1(GLS1)was significantly overexpressed.Meanwhile,tumor-derived GLS1 microvesicles drove M2macrophage polarization.Furthermore,angiogenesis promoted trastuzumab resistance.IHC showed high glutamine metabolism,M2 macrophage polarization,and angiogenesis in trastuzumab-resistant HER2-positive tumor tissues from patients and nudemice.Mechanistically,the cell division cycle 42(CDC42)promoted GLS1 expression in tumor cells by activating nuclear factor kappa-B(NF-κB)p65 and drove GLS1microvesicle secretion through IQmotif-containing GTPase-activating protein 1(IQGAP1).Based on the ABM and in vivo experiments,we confirmed that the combination of anti-glutamine metabolism,anti-angiogenesis,and pro-M1 polarization therapy had the best effect in reversing trastuzumab resistance in HER2-positive gastric cancer.Conclusions:This study revealed that tumor cells secrete GLS1 microvesicles via CDC42 to promote glutamine metabolism,M2 macrophage polarization,and pro-angiogenic function of macrophages,leading to acquired trastuzumab resistance in HER2-positive gastric cancer.A combination of anti-glutamine metabolism,anti-angiogenesis,and pro-M1 polarization therapy may provide a new insight into reversing trastuzumab resistance. | Xingbin Hu Zhenfeng Ma Beibei Xu Shulong Li Zhiqi Yao Bishan Liang Jiao Wang Wangjun Liao Li Lin Chunling Wang Siting Zheng Qijing Wu Qiong Huang Le Yu Fenghua Wang Min Shi | 2023 | Cancer Communications2023，43，8： | 0 |
| 9 | Molecular basis and mechanism of action of Albizia julibrissin in depression treatment and clinical application of its formulae显示文摘Albizzia julibrissin is empirically used as an antidepressant in clinical practice.Preclinical studies have indicated that its total extracts or bioactive constituents exerted antidepressant-like responses in animal models,providing the molecular basis to reveal its underlying mechanism of action.While attempts have been made to understand the antidepressant effect of A.julibrissin,many fundamental questions regarding its mechanism of action remain to be addressed at the molecular and systems levels.In this review,we conclusively discussed the mechanism of action of A.julibrissin and A.julibrissin formulae by reviewing recent preclinical and clinical studies conducted by using depressive animal models and depressive patients.Several representative bioactive constituents and formulae were highlighted as examples,and their mechanisms of action were discussed.In addition,some representative A.julibrissin formulae that have been shown to be compatible with conventional antidepressants in clinical practice were also reviewed.Furthermore,we discussed the future research directions to reveal the underlying mechanism of A.julibrissin at the molecular and systems levels in depression treatment.The integrated study using both the molecular and systematic approaches is required not only for improving our understanding of its molecular basis and mechanisms of action,but also for providing a way to discover novel agents or approaches for the effective and systematic treatment of depression. | Bishan Huang Yingyao Wu Chan Li Qingfa Tang Yuanwei Zhang | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
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