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| 1 | Industrial upgrading based on global innovation chains:A case study of Huawei technologies Co.,Ltd.Shenzhen显示文摘Although China is a global trade power,it has low value-added trade,which lies at the bottom of the global value chain.Therefore,there is an urgent need to change the unfavorable position of the international division of labor in China.The global innovation chain is a new development of innovation through which China can implement open innovation and utilize the world's advanced knowledge,technology,information,and other resources to enhance its innovation capabilities,promote industrial upgrading,and improve the status of its global value chains.This paper takes Huawei as an example of international cooperation and innovation,aspects that have allowed the company to rapidly improve its position and prestige in the industry.The case study of Huawei suggests that China should introduce talent,increase investment abroad,attract foreign investment,expand intellectual property trade,develop outsourcing and international strategic research and development alliances,build a global innovation chain,and promote industrial upgrading to elevate the status of its international division of labor. | Xuejun Lin Bingqian Liu Jiaxu Han Xiangyue Chen | 2018 | International Journal of Innovation Studies2018，2，3： | 5 |
| 2 | Bisulfite-free mapping of DNA cytosine modifications:challenges and perspectives显示文摘The mapping of DNA cytosine modifications is crucial for understanding the dynamic landscape of epigenetic regulation.While bisulfite sequencing has been the gold standard for decades,it suffers from limitations such as DNA degradation and low library quality due to harsh chemical treatment.In recent years,bisulfite-free methods have emerged as promising alternatives for detecting and quantifying DNA cytosine modifications.These methods employ enzymatic and chemical strategies to investigate cytosine modifications without the need for bisulfite treatment.This review provides an overview of the historical context of bisulfite-based methods and presents the current landscape of bisulfite-free methods.The advantages and limitations of each approach are discussed,along with insights into their applications.Furthermore,the review explores the existing challenges in the field and presents future perspectives and potential directions for advancing bisulfite-free mapping methods.The continued progress in bisulfite-free techniques holds great promise for unraveling the intricate nature of DNA cytosine modifications and their functional implications in diverse biological processes and diseases. | Yanfang Du Ying Tang Bingqian Lin Xiaochen Xue Yafen Wang Yibin Liu | 2023 | Science China Chemistry2023，66，11： | 0 |
| 3 | Chinese Tuina remodels the synaptic structure in neuropathic pain rats by downregulating the expression of N-methyl D-aspartate receptor subtype 2B and postsynaptic density protein-95 in the spinal cord dorsal horn显示文摘OBJECTIVE:To investigate whether the Chinese massage system,Tuina,exerts analgesic effects in a rat model of chronic constriction injury(CCI)by remodeling the synaptic structure in the spinal cord dorsal horn(SCDH).METHODS:Sixty-nine male Sprague–Dawley rats were randomly and evenly divided into the normal group,sham group,CCI group,CCI+Tuina group,CCI+MK-801[an N-methyl D-aspartate receptor subtype 2B(NR2B)antagonist]group,and CCI+MK-801+Tuina group.The neuropathic pain model was established using CCI with right sciatic nerve ligation.Tuina was administered 4 d after CCI surgery,using pressing manipulation for 10 min,once daily.Motor function was observed with the inclined plate test,and pain behaviors were observed by the Von Frey test and acetone spray test.At 19 d after surgery,the L3-L5 spinal cord segments were removed.Glutamate,interleukin 1β(IL-1β),and tumor necrosis factor-α(TNF-α)levels were detected by enzyme-linked immunosorbent assay.The protein expression levels of NR2B and postsynaptic density protein-95(PSD-95)were detected by Western blot,and the synaptic structure was observed by transmission electron microscopy(TEM).RESULTS:CCI reduced motor function and caused mechanical and cold allodynia in rats,increased glutamate concentration and TNF-αand IL-1βlevels,and increased expression of synapse-related proteins NR2B and PSD-95 in the SCDH.TEM revealed that the synaptic structure of SCDH neurons was altered.Most of these disease-induced changes were reversed by Tuina and intrathecal injection of MK-801(P<0.05 or<0.01).For the majority of experiments,no significant differences were found between the CCI+MK-801 and CCI+MK-801+Tuina groups.CONCLUSIONS:Chinese Tuina can alleviate pain by remodeling the synaptic structure,and NR2B and PSD-95 receptors in the SCDH may be among its targets. | HUANG Hongye WANG Bingqian CHEN Shuijin FANG Jiayu WANG Xiaohua CHEN Lechun JIANG Yu ZHANG Huanzhen CHEN Jincheng LIN Zhigang | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 0 |
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