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您的检索式：作者名="Bingjun Bai"
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| 1 | GmNMHC5 may promote nodulation via interaction with GmGAI in soybean显示文摘Soybean(Glycine max[L.]Merr.)is a food and oil crop whose growth and yield are influenced by root and nodule development.In the present study,Gm NMHC5 was found to promote the formation of nodules in overexpressing mutants.In contrast,the number of nodules in Gmnmhc5 edited with CRISPR/Cas9 decreased sharply.In 35 S:Gm NMHC5 mutants,expression levels of genes involved in nodulation were significantly up-regulated.Both in vitro and in vivo biochemical analyses showed that Gm NMHC5 directly interacted with Gm GAI(a DELLA protein),and the content of gibberellin 3(GA_(3))in overexpressing mutants was lower than that in the wild type.These results revealed that Gm NMHC5 participates in the classical GA signaling pathway,and may regulate the content of GA_3 to match the optimal concentration required for nodule formation,thereby promoting nodulation by directly interacting with Gm GAI.A model illustrating the mechanism by which Gm NMHC5 promotes soybean nodulation is presented. | Wenting Wang Zhili Wang Wensheng Hou Li Chen Bingjun Jiang Wenya Ma Lijuan Bai Wenwen Song Cailong Xu Tianfu Han Yongjun Feng Cunxiang Wu | 2022 | The Crop Journal2022，10，1： | 0 |
| 2 | Tumor-suppressive function and mechanism of HOXB13 in right-sided colon cancer显示文摘Right-sided colon cancer(RCC)and left-sided colon cancer(LCC)differ in their clinical and molecular features.An investigation of differentially expressed genes(DEGs)between RCC and LCC could contribute to targeted therapy for colon cancer,especially RCC,which has a poor prognosis.Here,we identified HOXB13,which was significantly less expressed in RCC than in LCC and associated with prognosis in RCC,by using 5 datasets from the Gene Expression Omnibus(GEO).Tissue sample analysis showed that HOXB13 was differentially expressed between normal and only RCC tumor tissues.HOXB13 inhibited colon cancer cell proliferation and induced apoptosis both in vitro and in vivo.Furthermore,we found that HOXB13 might be regulated by DNMT3B and suppress C-myc expression to exert antitumor effects viaβ-catenin/TCF4 signals in RCC.In conclusion,the current study is the first to demonstrate that HOXB13 has a tumor-suppressive effect in RCC.High expression levels of HOXB13 are associated with prolonged overall survival in patients with RCC.The DNMT3B-HOXB13-C-myc signaling axis might be a molecular target for the treatment of RCC. | Binbin Xie Bingjun Bai Yuzi Xu Yunlong Liu Yiming Lv Xing Gao Fei Wu Zhipeng Fang Ying Lou Hongming Pan Weidong Han | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 0 |
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