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| 1 | Effect of cholecystokinin octapeptide on tumor necrosis factor α transcription and nuclear factor-κB activity induced by lipopolysaccharide in rat pulmonary interstitial macrophages显示文摘AIM: To elucidate the anti-inflammatory mechanism ofan intestinal neuropeptide, sulfated cholecystokininoctapeptide (sCCK-8), the effects of sCCK-8 onlipopolysaccharide (LPS)-induced tumor necrosis factorpulmonary interstitial macrophages (PIMs) werestudied.METHODS: PIMs from rat were stimulated with LPS(:1mg @ L-1) in the presence or absence of sCCK-8 (10-8-:10-6mol@ L-1) or/and CCK receptor antagonistproglumide (2 mg @ L-1). The expression of TNF-α mRNAwas assayed by reverse transcription polymerase chainreaction (RT-PCR) at 3h of the stimulation, and nuclearelectrophoretic mobility shift assay (EMSA) at 1 h ofat 30 min of the stimulation was detected by Westernblot.RESULTS: sCCK-8, at concentrations from 10-8 mol @ L-1to 10-6 mol @ L-1 obviously inhibited LPS-induced TNF-αdependent manner, P<0.05, P<0.01. Stimulation PIMsP<0.01, which was elevated by sCCK-8, P<0.05. Thewere attenuated by CCK receptor antagonistproglumide, P<0.01.CONCLUSION: sCCK-8 inhibits LPS-induced TNF-α mRNAwhich is mediated through CCK receptors and inhibitinginflammatory mechanisms of sCCK-8. | Bin Cong Shu-Jin Li Yi-Ling Ling Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China Yu-Xia Yao Molecular Biological Laboratory,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China Gui-jun Zhu Department of chest surgey,The Fourth Hospital,Hebei Medical University,Shijiazhuang 050017,Hebei Province,China | 2002 | World Journal of Gastroenterology2002，8，4： | 31 |
| 2 | First total synthesis of (±)-abyssinoflavanone V显示文摘全部的合成(卤)-abyssinoflavanone V 首先通过 C-prenylation,酉分的氢氧根组的选择保护,丁间醇醛冷凝作用,环合和从便宜 4-hydroxybenzaldehyde 和 2,4,6-trihydroxyacetophenone 开始的 deprotection 被完成,与全部的产量 24% 。新混合物的所有结构被红外, 1H NMR 和 MS 证实。 | Jin Hui Yang Yan Min Zhao Cong Bin Ji | 2008 | Chinese Chemical Letters2008，19，6： | 19 |
| 3 | Effect of endogenous hydrogen sulfide on oxidative stress in oleic acid-induced acute lung injury in rats显示文摘背景尖锐的肺损害(所有)是在在 ALl.Endogenous 氢硫化物( H2S )的致病的一个重要角色能禁止的紧急情况 care.Oxidative 压力戏的普通批评疾病在老鼠的氧化应力胃的 mucosal epithelium.In 这研究,我们在 rats.Methods 在油的导致酸的尖锐的肺损害在氧化压力的规定检验了 H2S 的可能的角色所有的老鼠模特儿被油的酸( OA )的intra尾巴静脉注射劝诱 .NaHs 答案被注射 | WANG Cong WANG Hai-ying LIU Zhi-wei FU Yan ZHAO Bin | 2011 | Chinese Medical Journal2011，，21： | 15 |
| 4 | Genetic variation of yellow pigment and its components in foxtail millet(Setaria italica(L.) P.Beauv.) from different eco-regions in China显示文摘Kernel color is an important trait for assessing the commercial and nutritional quality of foxtail millet.Yellow pigment content(YPC)and carotenoid components(lutein and zeaxanthin)of 270 foxtail millet accessions,including 50 landraces and 220improved cultivars,from four different eco-regions in China were surveyed using spectrophotometry and high performance liquid chromatography methods.Results indicated that YPC had rich variance,ranging from 1.91 to 28.54 mg kg^(–1),with an average value of 17.80 mg kg^(–1).The average YPC of improved cultivars(18.31 mg kg^(–1))was significantly higher than that of landraces(15.51 mg kg^(–1)).The YPC in cultivars from the Loess Plateau spring sowing region(LPSSR)was the highest(20.59 mg kg^(–1)),followed by the North China summer sowing region(NCSSR,18.25 mg kg^(–1)),the northeast spring sowing region(NSSR,17.25 mg kg^(–1)),and the Inner Mongolia Plateau spring sowing region(IMPSSR,13.92 mg kg^(–1)).The variation coefficients of YPC in cultivars from NSSR,LPSSR,and IMPSSR were higher than that from NCSSR.A similar carotenoid profile was also obtained for 270 foxtail millet cultivars.Lutein and zeaxanthin accounted for approximately 55–65%of YPC in accessions.The lutein content was higher than zeaxanthin content in all cultivars.The ratio of lutein to zeaxanthin ranged from 1.51 to 6.06 with an average of 3.34.YPC was positively correlated with lutein(r=0.935,P<0.01),zeaxanthin(r=0.808,P<0.01),and growth duration(r=0.488,P<0.01),whereas it was negatively correlated with grain protein(r=-0.332,P<0.01)and 1 000-kernel weight(r=-0.153,P<0.05).Our study is useful for screening and selecting cultivars with high levels of yellow pigment and for enhancing phytochemical concentrations in breeding programs. | YANG Yan-bing JIA Guan-qing DENG Li-gang QIN Ling CHEN Er-ying CONG Xin-jun ZOU Ren-feng WANG Hai-lian ZHANG Hua-wen LIU Bin GUAN Yan-an DIAO Xian-min YIN Yan-ping | 2017 | Journal of Integrative Agriculture2017，16，11： | 15 |
| 5 | Indoor SVOC pollution in China:A review显示文摘Epidemiological and toxicological studies have proved that semi-volatile organic compounds (SVOCs) may have significant adverse effects on human health.For example,phthalic acid esters (PAEs),polybrominated diphenyl ethers (PBDEs) and polycyclic aromatic hydrocarbons (PAHs) may harm the endocrine,reproductive and respiratory systems of humans.Moreover,some SVOCs are carcinogenic.This paper summarizes the source emission characteristics for typical SVOCs observed indoors,evaluates the gas-phase and particle-phase concentrations of indoor di-2-ethylhexyl phthalate (DEHP) under the steady-state condition,estimates the exposure of PAEs and the health risk of PAHs,and then proposes some solutions to some urgent problems for indoor SVOC pollution.The results show that the production and consumption quantities of plasticizers,coal and cigarettes in China are the highest in the world,and that the consumption of flame retardants and pesticides are also very high.As estimated,indoor plasticizer and flame retardant concentrations are higher in China than that of the developed countries such as the USA,which implies that indoor SVOC pollution may be more serious in China.According to the model analysis,DEHP remains mainly in the particle-phase under the steady-state condition;the particle-phase concentration of DEHP increases with increasing particle concentration.The exposure of DEHP is higher for children than it is for adults.It is estimated that 260 thousand people are diagnosed with cancer resulting from exposure to PAHs every year.A multidisciplinary approach to the further study of indoor SVOC pollution is necessary. | WANG LiXin ZHAO Bin LIU Cong LIN Hui YANG Xu ZHANG YinPing | 2010 | Chinese Science Bulletin2010，55，15： | 13 |
| 6 | Hydrogen sulfide donor regulates alveolar epithelial cell apoptosis in rats with acute lung injury显示文摘 | LIU Wen-li LIU Zhi-wei LI Tian-shui WANG Cong ZHAO Bin | 2013 | Chinese Medical Journal2013，，3： | 13 |
| 7 | Enhanced invasion in vitro and the distribution patterns in vivo of CD133+ glioma stem cells显示文摘背景最近的研究建议了癌症干细胞基于他们的电阻引起肿瘤复发到放射疗法和 chemotherapy.Although glioblastoma 房间的高度侵略的性质也在当前的治疗的失败被含有,癌症干细胞是否涉及学习试图估计在 Sprague-Dawley ( SD )老鼠大脑肿瘤从 C6 glioma 房间线和 GSC 的分发模式导出的 glioma 干细胞( GSC )的侵略能力的 invasiveness.This 。 | YU Sheng-ping YANG Xue-jun ZHANG Bin MING Hao-lang CHEN Cong REN Bing-cheng LIU Zhi-feng LIU Bin | 2011 | Chinese Medical Journal2011，，17： | 12 |
| 8 | A Domestication-Associated Gene GmPRR3b Regulates the Circadian Clock and Flowering Time in Soybean显示文摘Improved soybean cultivars have been adapted to grow at a wide range of latitudes,enabling expansion of cultivation worldwide.However,the genetic basis of this broad adaptation is still not clear.Here,we report the identification of GmPRR3b as a major flowering time regulatory gene that has been selected during domestication and genetic improvement for geographic expansion.Through a genome-wide association study of a diverse soybean landrace panel consisting of 279 accessions,we identified 16 candidate quantitative loci associated with flowering time and maturity time.The strongest signal resides in the known flowering gene E2,verifying the effectiveness of our approach.We detected strong signals associated with both flowering and maturity time in a genomic region containing GmPRR3b.Haplotype analysis revealed that GmPRR3bH6 is the major form of GmPRR3b that has been utilized during recent breeding of modern cultivars.mRNA profiling analysis showed that GmPRR3bH6 displays rhythmic and photoperiod-dependent expression and is preferentially induced under long-day conditions.Overexpression of GmPRR3bH6 increased main stem node number and yield,while knockout of GmPRR3bH6 using CRISPR/Cas9 technology delayed growth and the floral transition.GmPRR3bH6 appears to act as a transcriptional repressor of multiple predicted circadian clock genes,including GmCCAIa,which directly upregulates J/GmELF3a to modulate flowering time.The causal SNP(Chr12:5520945)likely endows GmPRR3bH6 a moderate but appropriate level of activity,leading to early flowering and vigorous growth traits preferentially selected during broad adaptation of landraces and improvement of cultivars. | Cong Li Ying-hui Li Yanfei Li Hongfeng Lu Huilong Hong Yu Tian Hongyu Li Tao Zhao Xiaowei Zhou Jun Liu Xinan Zhou Scott A.Jackson Bin Liu Li-juan Qiu | 2020 | Molecular Plant2020，13，5： | 11 |
| 9 | Speciation and fractionation of heavy metals in soil experimentally contaminated with Pb, Cd, Cu and Zn together and effects on soil negative surface charge显示文摘Speciation and fractionation of heavy metals in soil subsamples experimentally loaded with Pb, Cd, Cu and Zn in orthogonal design was investigated by sequential extraction, and operationally defined as water soluble and exchangeable(SE), weakly specific adsorbed(WSA), Fe and Mn oxides bound(OX) and organic bound(ORG). The results showed that fractions of heavy metals in the soil subsamples depended on their speciation. About 90% of Cd and 75% of Zn existed in soil subsamples in the SE fraction. Lead and Cu existed in soil subsamples as SE, WSA and OX fractions simultaneously, although SE was still the major fraction. Organic bound heavy metals were not clearly apparent in all the soil subsamples. The concentration of some heavy metal fractions in soil subsamples showed the good correlation with ionic impulsion of soil, especially for the SE fraction. Continuous saturation of soil subsamples with 0.20 mol/L NH 4Cl, which is the first step for determination of the negative surface charge of soil by the ion retention method, resulted in desorption of certain heavy metals from the soil. It was found that the percentage desorption of heavy metals from soil subsamples depended greatly on pH, the composition and original heavy metal content of the soil subsamples. However, most of the heavy metals in the soil subsamples were still be retained after multiple saturation. Compared with the parent soil, the negative surface charge of soil subsamples loaded with heavy metals did not show difference significantly from that of the parent one by statistical analysis. Heavy metals existed in the soil subsamples mainly as exchangeable and precipitated simultaneously. | ZHOU Dong mei, HAO Xiu zhen, TU Cong, CHEN Huai man, SI You bin (Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China. ) | 2002 | Journal of Environmental Sciences2002，14，4： | 10 |
| 10 | Cancer-associated fibroblasts in breast cancer:Challenges and opportunities显示文摘The tumor microenvironment is proposed to contribute substantially to the progression of cancers,including breast cancer.Cancer-associated fibroblasts(CAFs)are the most abundant components of the tumor microenvironment.Studies have revealed that CAFs in breast cancer originate from several types of cells and promote breast cancer malignancy by secreting factors,generating exosomes,releasing nutrients,reshaping the extracellular matrix,and suppressing the function of immune cells.CAFs are also becoming therapeutic targets for breast cancer due to their specific distribution in tumors and their unique biomarkers.Agents interrupting the effect of CAFs on surrounding cells have been developed and applied in clinical trials.Here,we reviewed studies examining the heterogeneity of CAFs in breast cancer and expression patterns of CAF markers in different subtypes of breast cancer.We hope that summarizing CAFrelated studies from a historical perspective will help to accelerate the development of CAF-targeted therapeutic strategies for breast cancer. | Dengdi Hu Zhaoqing Li Bin Zheng Xixi Lin Yuehong Pan Peirong Gong Wenying Zhuo Yujie Hu Cong Chen Lini Chen Jichun Zhou Linbo Wang | 2022 | Cancer Communications2022，42，5： | 9 |
| 11 | First total synthesis of two nematicidal prenylated flavanones显示文摘全部的合成(±)-8-(3-methylbut-2-enyl)-2-phenyl-2,3-dihydrochromen-4-one 并且(±)-2-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one 首先通过 C-prenylation,酉分的氢氧根组的保护,丁间醇醛冷凝作用,环合和从便宜 benzaldehyde, 4-hydroxybenzaldehyde 和 2-hydroxyacetophenone 开始的 deprotection 被完成,与 20 和 16.3% 的全部的产量。新混合物的所有结构被红外证实, 1 H NMR 和 MS。 | Jin Hui Yang Shi Zhi Jiang Yan Min Zhao Yun Feng Li Cong Bin Ji Wan Yi Liu | 2009 | Chinese Chemical Letters2009，20，9： | 9 |
| 12 | Electrical response grading versus House-Brackmannscale for evaluation of facial nerve injury after Bell's palsy: a comparative study显示文摘OBJECTIVE: There are no convenient techniques to evaluate the degree of facial nerve injury during a course of acupuncture treatment for Bell's palsy. Our previous studies found that observing the electrical response of specific facial muscles provided reasonable correlation with the prognosis of electroacupuncture treatment. Hence, we used the new method to evaluate the degree of facial nerve injury in patients with Bell's palsy in comparison with the House-Brackmann scale. The relationship between therapeutic effects and prognosis was analyzed to explore an objective method for evaluating Bell's palsy. METHODS: The facial nerve function of 68 patients with Bell's palsy was assessed with both electrical response grading and the House-Brackmann scale before treatment. Then differences in evaluation results of the two methods were compared. All enrolled patients received electroacupuncture treatment with disperse-dense wave at 1/100 Hz for 4 weeks. After treatment, correlation analysis was conducted to fi nd the relationship between electrical response and therapeutic effects or prognosis.RESULTS: Checking consistency between electrical response grading and House-Brackmann scale: Kappa value 0.028(P = 0.578). Correlation analysis: the two methods were correlated with the prognosis, and electrical response grading(rER = 0.789) was better than the House-Brackmann scale(rHB = 0.423). CONCLUSION: Electrical response grading is superior to the House-Brackmann scale in efficacy and reliability, and can conveniently assess the degree of facial nerve injury. The House-Brackmann scale is suitable for the patients with mild facial nerve injury, but its evaluation quality for severe facial nerve injury is poor. | Bin Huang Zhang-ling Zhou Li-li Wang Cong Zuo Yan Lu Yong Chen | 2014 | Journal of Integrative Medicine2014，12，4： | 9 |
| 13 | Biology,invasion and management of the agricultural invader:Fall armyworm,Spodoptera frugiperda(Lepidoptera:Noctuidae)显示文摘The fall armyworm(FAW),Spodoptera frugiperda(J.E.Smith),is native to the Americas.It has rapidly invaded 47 African countries and 18 Asian countries since the first detection of invasion into Nigeria and Ghana in 2016.It is regarded as a super pest based on its host range(at least 353 host plants),its inherent ability to survive in a wide range of habitats,its strong migration ability,high fecundity,rapid development of resistance to insecticides/viruses and its gluttonous characteristics.The inherently superior biological characteristics of FAW contribute to its invasiveness.Integrated pest management(IPM)of FAW has relied on multiple applications of monitoring and scouting,agricultural control,chemical pesticides,viral insecticides,sex attractants,bio-control agents(parasitoids,predators and entomopathogens)and botanicals.Knowledge gaps remain to be filled to:(1)understand the invasive mechanisms of S.frugiperda;(2)understand how to prevent its further spread and(3)provide better management strategies.This review summarizes the biological characters of FAW,their association with its invasiveness and IPM strategies,which may provide further insights for future management. | Jing WAN HUANG Cong LI Chang-you ZHOU Hong-xu REN Yong-lin LI Zai-yuan XING Long-sheng ZHANG Bin QIAO Xi LIU Bo LIU Cong-hui XI Yu LIU Wan-xue WANG Wen-kai QIAN Wan-qiang Simon MCKIRDY WAN Fang-hao | 2021 | Journal of Integrative Agriculture2021，20，3： | 7 |
| 14 | Empirical analysis of airport network and critical airports显示文摘Air transport network, or airport network, is a complex network involving numerous airports. Effective management of the air transport system requires an in-depth understanding of the roles of airports in the network. Whereas knowledge on air transport network properties has been improved greatly, methods to find critical airports in the network are still lacking. In this paper, we present methods to investigate network properties and to identify critical airports in the network. A novel network model is proposed with airports as nodes and the correlations between traffic flow of airports as edges. Spectral clustering algorithm is developed to classify airports. Spatial distribution characteristics and intraclass correlation of different categories of airports are carefully analyzed. The analyses based on the fluctuation trend of distance-correlation and power spectrum of time series are performed to examine the self-organized criticality of the network. The results indicate that there is one category of airports which dominates the self-organized critical state of the network. Six airports in this category are found to be the most important ones in the Chinese air transport network. The flights delay occurred in these six airports can propagate to the other airports, having huge impact on the operation characteristics of the entire network. The methods proposed here taking traffic dynamics into account are capable of identifying critical airports in the whole air transport network. | Cong Wei Hu Minghua Dong Bin Wang Yanjun Feng Cheng | 2016 | Chinese Journal of Aeronautics2016，29，2： | 7 |
| 15 | Effect of cholecystokinin octapeptide on diacylglyceroI-PKC signaling pathway in rat pulmonary interstitial macrophages stimulated by lipopolysaccharide显示文摘Aim:To investigate the effect of cholecystokinin octapeptide(CCK-8)on thediacylglycerol-protein kinase C(DAG-PKC)signaling pathway in rat pulmonaryinterstitial macrophages(PIM)stimulated by lipopolysaccaride(LPS).Methods:The PIM from rat lung tissues were isolated using the collagenase digestionmethod combined with alveolar lavage and pulmonary vessel perfusion.DAGcontent and PKC activity were measured by radioenzymatic assay.The transloca-tion of PKCζ was determined by semi-quantitative immunoblot analysis.Results:CCK-8,at high concentrations(1×10^(-6)-1×10^(-5)mol/L),decreased DAG content andinhibited PKC activity and PKCζ translocation compared with that in rat restingPIM of a control group(P<0.01).LPS increased DAG content,and promoted PKCactivity and PKC~ translocation(P<0.01).CCK-8 decreased LPS-induced DAGcontent and inhibited LPS-induced PKC activity and PKCζ translocation signifi-cantly at 1×10^(-8)-1×10^(-5)mol/L(P<0.01).This inhibitory effect of CCK-8 could beabrogated partly by proglumide(non-selective CCK receptor antagonist),CR-1409(selective CCK-A receptor antagonist),and CR-2945(selective CCK-Breceptor antagonist)in a concentration-dependent manner(P<0.01).Conclusion:CCK-8 was a negative modulator of the DAG-PKC signaling pathway in rat restingPIM,which is very important for maintaining body homeostasis.It significantlyinhibited LPS-induced DAG content,PKC activity and PKCζ translocation in aconcentration-dependent manner.The CCK receptor,especially the CCK-Areceptor,might play a major role in this process. | Shun-jiang XU Wei-juan GAO Bin CONG Chun-ling MA Shu-jin LI Yi-ling LING Zhen-yong GU Yu-xia YAO | 2005 | Acta Pharmacologica Sinica2005，26，12： | 6 |
| 16 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 17 | Prediction of the precessing vortex core in the Francis-99 draft tube under off-design conditions by using Liutex/Rortex method显示文摘The turbulent flow in the draft tube of a Francis turbine is very complicated while working under off-design conditions. Although the off-design conditions were widely studied, the vortex core line in the draft tube of a Francis turbine with splitter blades is not well understood, especially the vortex rope property. This letter presents a prediction of the behavior of the vortex rope in the draft tube of the Francis-99 turbine obtained by the computational fluid dynamics (CFD), where the Liutex/Rortex method, as the most recent vortex definition, is applied to analyze the periodical precession of the vortex rope in the draft tube cone. The advantage of this Liutex/Rortex method is shown by its enhanced ability to represent the vortex rope structurewith the vortex-core lines. Furthermore, since it seems to be very hard to define a sharp boundary surface for the whole vortex structure, it is advantageousfocusing only on the vortex core line,by which different vortex structures can be clearly differentiated. The evolution of the vortex core and the process of the vortex breakdown in the draft tube are revealed, which might help to comprehend the development of the turbulent flow in the draft tube. | Cong Trieu Tran Xin-ping Long Bin Ji Chaoqun Liu | 2020 | Journal of Hydrodynamics2020，32，3： | 6 |
| 18 | Hypomethylation of proximal CpG motif of interleukin-lO promoter regulates its expression in human rheumatoid arthritis显示文摘目的: 人的 interleukin-10 (IL10 ) 的倡导者,为压制发炎关键的 cytokine 和调整有免疫力的回答,与 CpG 主题包含一个保存 interspecies 的序列。这研究的目的是调查 CpG 主题的 methylation 是否能在风湿性关节炎(RA ) 调整 IL10 的表示。 | Li-hong FU Chun-ling MA Bin CONG Shu-jin LI Hai-ying CHEN Jing-ge ZHANG | 2011 | Acta Pharmacologica Sinica2011，32，11： | 6 |
| 19 | A transient expression system in soybean mesophyll protoplasts reveals the formation of cytoplasmic GmCRY1 photobody-like structures显示文摘Soybean(Glycine max(L.) Merr.), grown for its plant oils and proteins, is one of the most important crops throughout the world.Generating stable and heritable transgenic soybeans is relatively inefficient;therefore, there is an urgent need for a simple and high-efficient transient transformation method by which to enable the investigation of gene functions in soybeans, which will facilitate the elucidation and improvement of the molecular mechanisms regulating the associated agronomic traits. We established a system of transient expression in soybean mesophyll protoplasts and obtained a high level of protoplast transfection efficiency(up to 83.5%). The subcellular activity of the protoplasts was well preserved, as demonstrated by the dynamic formation of GmCRY nucleus photobodies(NPs) and/or cytoplasmic photobody-like structures(CPs) in response to blue light.In addition, we showed that GmCRY1b CPs colocalized with GmCOP1b, a co-ortholog of Arabidopsis thaliana CONSTITUTIVE PHOTOMORPHOGENIC 1(COP1), which provided new insight into the potential roles of GmCRY1s in the cytoplasm. | Lu Xiong Cong Li Hongyu Li Xiangguang Lyu Tao Zhao Jun Liu Zecheng Zuo Bin Liu | 2019 | Science China(Life Sciences)2019，62，8： | 6 |
| 20 | Echinococcus Granulosus: Suitable in vitro Protoscolices Culture Density显示文摘The present study is to determine the suitable protoscolices (PSCs) density for long-time culturing in vitro.The PSCs were divided into eight groups with different densities and the viability tests were carried out with 0.1%methylene blue staining.Then the infection ability of cultured PSCs was assessed by the mean cyst weight of mice inoculated intraperitoneally with PSCs after 8 months post-infection.During the 22 days of culture。 | LIU Cong Shan ZHANG Hao Bing YIN Jian Hai JIANG Bin HAN Xiu Min | 2013 | Biomedical and Environmental Sciences2013，26，11： | 5 |
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