|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Global Analysis of Protein Activities Using Protein Chips显示文摘 | Bilgin M Bangham R | 2001 | Science2001，293，5537： | 1 |
| 3 | The regional cerebral blood flow changes in major depressive disorder with and without psychotic features 显示文摘 | Gonul AS Kula M Bilgin AG | 2004 | Prog Neuropsychopharmacol Biol Psychiatry2004，28，6： | 1 |
| 4 | Global analysisof protein activities using proteome chips 显示文摘 | ZHU H BILGIN M BANGHAM R | 2001 | Science2001，293，5537： | 1 |
| 5 | Role of ghrelin in the regulation of gastric acid secretion involving nitrergic mechanisms in rats显示文摘 | Bilgin H M Tumer C Diken H Kelle M Sermet A | 2008 | Physiol Res2008，57，： | 1 |
| 6 | Comparison of non-linear models for describing the growth of scrotal circumference in Awassi male lambs显示文摘 | Bilgin O C Emsen E Davis M E | 2004 | Small Rumi- nant Research2004，52，： | 1 |
| 7 | Comprcssion of electrocardiogram signals using JPEG2000显示文摘 | Bilgin A Marcellin M V Ahhach M I | 2003 | IEEE Transactions on Consumer Electronics2003，49，4： | 1 |
| 8 | For which cancer types can neuron-specific enolase be clinically helpful in Turkish patients? 显示文摘 | Bilgin E Dizdar Y Serilmez M | 2013 | Asian Pac J Cancer Prey2013，14，4： | 1 |
| 9 | Global analysis of protein activities using proteome chips显示文摘 | Zhu H Bilgin M Bangham R | 2001 | Science2001，293，5537： | 1 |
| 10 | The PEARL Model: Gaining Competitive Advan- tage Through Sustainable Development 显示文摘 | Bilgin M | 2009 | Journal of Busi- ns Ethics2009，85，3： | 1 |
| 11 | Global analysis of protein activities using proteome chips 显示文摘 | Zhu H Bilgin M Bangham R | 2001 | Science2001，293，5537： | 1 |
| 12 | Growth performance of Awassi lambs fed calf milk replacer显示文摘 | Emsen E M Yaprak M Bilgin O C | 2004 | Small Ruminant Re search2004，53，： | 1 |
| 13 | Technology trans- fer and enterprise performance: A firm-level analysis in China显示文摘 | Bilgin M H Lau C M Karabulut G | 2012 | Journal of Business Economics and Manage- ment2012，13，3： | 1 |
| 14 | Global analysis of protein activities using proteome chips显示文摘 | Zhu H Bilgin M Bangham R | 2001 | Science2001，293，5537： | 1 |
| 15 | Re-evaluation of building damage during recent earthquakes in Turkey 显示文摘 | Inel M Omen H B Bilgin H | 2008 | Engineering Structures2008，30，2： | 1 |
| 16 | Living-related partial liver transplantation in pediatric patients显示文摘 | Haberal M Bilgin N | 1998 | Transplantation Proceedings1998，30，： | 1 |
| 17 | Resourceconstrained rate control for motion JPEG2000显示文摘 | Dagher J C Ali Bilgin Marcellin M W | 2003 | IEEE Trans Image Processing2003，12，12： | 1 |
| 18 | Which is a better treatment for carotid artery stenosis :stenting or endarterectomy?显示文摘 | BURGAZLI KM BILGIN M KAVUKCU E | 2013 | Eur Rev Med Pharmacol Sci2013，17，8： | 1 |
| 19 | Dominant rock properties affecting the performance of conical picks and the comparison of some experimental and theoretical results 显示文摘 | Bilgin N Demircin M A Copur H | 2006 | International Journal of Rock Mechanics & Mining Science2006，3，： | 1 |
| 20 | Identification of Four Soybean Reference Genes for Gene Expression Normalization 显示文摘 | Libauh M Thibivilliers S Bilgin D D | 2008 | The Plant Genome2008，1，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员