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| 1 | Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy显示文摘Paclitaxel(PTX) is one of the most effective anticancer drugs for the treatment of various solid tumors, but its clinical use is limited by its poor solubility, low bioavailability, and severe systemic toxicity. Encapsulation of PTX in polymeric nanoparticles is used to overcome these problems but these micelles still need improvements in stability, pharmacokinetics, therapeutic efficacy, and safety profiles. In this study, we demonstrate a facile fabrication of a stable PTX-binding micelle made from poly(ethylene glycol)-block-dendritic polylysine, whose primary amines were reacted with phenethyl isothiocyanate(PEITC), a hydrophobic anticancer agent under clinical study. The amphiphilic conjugate(PEG-Gx-PEITC; Gx, the generation of the polylysine dendron) formed well-defined micelles whose core was composed of phenyl groups and thiourea groups binding PTX via π-π stacking and hydrogen bonding. Compared with the PTX-loaded poly(ethylene glycol)-block-poly(D,L-lactide)(PEGPDLLA/PTX) micelles in clinical use, PTX-loaded PEG-Gx-PEITC third-generation(PEG-G3-PEITC/PTX) micelles showed slowed blood clearance, enhanced tumor accumulation, and thus much improved in vivo therapeutic efficacy in both subcutaneous and orthotopic human breast cancer xenografts. Therefore, PEG-G3-PEITC is a promising drug delivery system for PTX in the treatment of breast cancer. | Jiajia Xiang Bihan Wu Zhuxian Zhou Shiqi Hu Ying Piao Quan Zhou Guowei Wang Jianbin Tang Xiangrui Liu Youqing Shen | 2018 | Science China(Life Sciences)2018，61，4： | 6 |
| 2 | Viability Thresholds of Ischemic Penumbra of Hyperacute Stroke Defined by Perfusion-Weighted MRI and Apparent Diffusion Coefficient显示文摘 | L. R?hl L. ?stergaard C.Z. Simonsen P. Vestergaard-Poulsen G. Andersen M. Sakoh D. Le Bihan C. Gyldensted | 2001 | Stroke: Journal of the American Heart Association2001，，5： | 2 |
| 3 | Singular value decomposition of quaternion matrices: a new tool for vector-sensor signal processing显示文摘 | Nicolas Le Bihan Jér?me Mars | 2004 | Signal Processing2004，，7： | 2 |
| 4 | MR imaging ofintravox- el incoherent motions: application to difusion an d perfusion in neurologic disorder显示文摘 | Le Bihan D Breton E Lallemand D | 1986 | Radiology1986，161，2： | 1 |
| 5 | Diffusion tensor imaging:concepts and applications 显示文摘 | Le Bihan D Mangin J F Poupon C | 2001 | J Magn Reson Imaging2001，13，4： | 1 |
| 6 | Diffusion tensor imaging: concepts and applications显示文摘 | Le Bihan D Mangin JF Poupon C | 2001 | J Magn Reson Imaging2001，13，4： | 1 |
| 7 | Echo-planarimaging of diffusion and perfusion显示文摘 | Turner R Le Bihan D Chesnick AS | 1991 | Magn Reson Med1991，19，2： | 1 |
| 8 | Ghrelin levels and sleeve gastrectomy in super-super-obesity显示文摘 | Cohen R Uzzan B Bihan H | 2005 | Obes Surg2005，15，10： | 1 |
| 9 | Evaluation of an integrated strategy for proteomic profiling of skeletal muscle显示文摘 | Tarelli E | 2004 | Proteomics2004，4，9： | 1 |
| 10 | Differentiation of Benign Versus Pathologic Compression Fractures with Diffusion-Weighted MR Imaging:a Closer Step toward the 'Holy Grail' of Tissue Characterization显示文摘 | Le Bihan DJ | 1998 | Radiology1998，207，2： | 1 |
| 11 | MR diffusion tensor spectroscopy and imaging显示文摘 | P Basser J Mattiello D Le Bihan | 1994 | Biophysical Journal1994，66，： | 1 |
| 12 | Echo-planar imaging of intravoxel incoherent motion显示文摘 | Turner R Le Bihan D Maier J | 1990 | Radiology1990，177，2： | 1 |
| 13 | Syntax production in bilinguals显示文摘 | Golestani N Alario F X Meriaux S Bihan L D Dehaene S Pallier C | | 0，，： | 1 |
| 14 | MR imaging of in- travoxel incoherent motions: application to diffusion and perfu- sion in neurologic disorders显示文摘 | Le Bihan D Breton E Lallemand D | 1986 | Radiology1986，161，2： | 1 |
| 15 | Diffusion tensor imaging:concepts and applications显示文摘 | Le Bihan D Mangin JF Poupon C | | 0，，： | 1 |
| 16 | Temperature mapping with MR imaging of molecular diffusion: application to hyperthermia显示文摘 | Le Bihan D Delannoy J Levin RL | 1989 | Radiology1989，171，3： | 1 |
| 17 | Looking into the functional architecture of the brain with diffusion MRI显示文摘 | Le Bihan D | 2003 | Nat Rev Neurosci2003，4，： | 1 |
| 18 | Looking into the functional architecture of the brain with diffusion MRI显示文摘 | Le Bihan D | 2003 | Nature Rev Neurosci2003，4，6： | 1 |
| 19 | Multi sensor probe and defect classification in eddy current tubing inspection显示文摘 | Joubert P Y Le Bihan Y | 2006 | Sensors and Actuators A: Physical2006，129，12： | 1 |
| 20 | Quaternion--MUSIC for vector- sensor array processing 显示文摘 | Sebastian Miron Nicolas Le Bihan | 2006 | IEEE Transactions on Signal Processing2006，54，4： | 1 |
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