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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | MOS characteristics of ultrathin NO-grown oxynitrides显示文摘 | BHAT M KIM J YOON G W | 1994 | IEEE Trans Elec Dev1994，15，10： | 1 |
| 3 | Efficient Prins cyclization in environmentally benign method using ion exchange re- sin catalyst显示文摘 | More G P Rane M Bhat S V | 2012 | Green Chem Lett Rev2012，5，1： | 1 |
| 4 | Glyoxalase I is critical for human retinal capillary pericyte survival under hyperglycemic conditions显示文摘 | Miller A G Smith D G Bhat M | 2006 | J Biol Chem2006，281，11： | 1 |
| 5 | A simple general synthesis of 1-alkynyldiisop ropoxyboranes 显示文摘 | Brown H C Bhat N G Srebnik M | 1988 | Tetrahedron Letters1988，29，22： | 1 |
| 6 | The protein data bank显示文摘 | Berman H M Westbrook J Feng Z K Gilliland G Bhat T N Weissig H Shindyalov L N Bourne P E | | 0，，01： | 1 |
| 7 | FoxM1 is a general target for pro- teasome inhibitors 显示文摘 | Bhat U G Halasi M Gartel A L | 2009 | PLoS One2009，4，： | 1 |
| 8 | Selective inhibition of cyclooxygenase by C-phycocyanin, a biliprotein from Spirulina platensis显示文摘 | Reddy C M Bhat V B Kiranmai G | 2000 | Biochem Biophys Res Commun2000，277，： | 1 |
| 9 | Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells显示文摘 | Bhat U G Halasi M Gartel A L | 2009 | PLoS One2009，，5： | 1 |
| 10 | A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties显示文摘 | Olsen D B Eldrup AB Bartholomew L Bhat B Bosserman M R Ceccacci A Colwell L F Fay J F Flores O A Getty K L Grobler J A LaFemina R L Markel E J Migliaccio G Prhavc M Stahlhut M W Tomassini J E MacCoss M Hazuda D J Carroll S S | | 0，，10： | 1 |
| 11 | Spectrophotometric determination of selenium using potassium iodide and starch as reagents显示文摘 | Narayana B Mathew M Bhat N G | 2003 | Microchim Acta2003，141，： | 1 |
| 12 | Financing marine protected areas in Jamaica : An exploratory study 显示文摘 | Reid G K Bhat M G | 2009 | Marine Policy2009，33，1： | 1 |
| 13 | Sanjay Gupta isozyme - based genetic similarity in Cenchrus (Poaceae) 显示文摘 | Bhat B V Vishnu Bhat Gupta M G | 2007 | Range Management and Agroforestry2007，28，： | 1 |
| 14 | Valuable components of raw and ripe peels from two Indian mango varieties显示文摘 | AJILA C M BHAT S G UJ S P RAO | 2007 | Food Chemistry2007，，102： | 1 |
| 15 | Nickel induced crystallization of amorphous silicon thin films显示文摘 | JIN Z H BHAT G A YEUNG M | 1998 | J Appl Phys1998，84，1： | 1 |
| 16 | Star pattern identification using discrete attitude variation technique显示文摘 | Rao G N Bhat M S Alex T K | 2005 | Journal of Guidance Control and Dynamics2005，28，6： | 1 |
| 17 | Phytophthora sojae races in Ohio over a 10-year interval显示文摘 | Schrnitthenner A F Hobe M Bhat R G | 1994 | Plant Disease1994，78，： | 1 |
| 18 | Properties and Performance of Commercial TiCN Coatings显示文摘 | Bull S J Bhat D G Staia M H | 2003 | Surface and Coatings Technology2003，，： | 1 |
| 19 | Thermophilic fungi:their physiology and enzymes显示文摘 | MAHESHWARI R BHARADWAJ G BHAT M K | 2000 | Microb Mol Biol Rev2000，，64： | 1 |
| 20 | Properties and Performance of Commercial TiCN Coatings显示文摘 | Bull S J Bhat D G Staia M H | 2003 | Surface and Coatings Technology2003，，： | 1 |
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