|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus显示文摘BACKGROUND Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs(miRs) that play important roles in the regulation of biological processes such as cell proliferation and hepatic fibrosis.AIM To assess diffusion-weighted magnetic resonance imaging and miRs in diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.METHODS This prospective study included 208 patients and 82 age-and sex-matched controls who underwent diffusion-weighted magnetic resonance imaging of the abdomen, miR profiling, and liver biopsy. Pathological scoring was classified according to the METAVIR scoring system. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with pathological scoring.RESULTS The ADC value decreased significantly with the progression of fibrosis, from controls(F0) to patients with early fibrosis(F1 and F2) to those with late fibrosis(F3 and F4)(median 1.92, 1.53, and 1.25 × 10^(-3) mm^2/s, respectively)(P = 0.001).The cut-off ADC value used to differentiate patients from controls was 1.83 × 10^(-3) mm^2/s with an area under the curve(AUC) of 0.992. Combining ADC and miR-200 b revealed the highest AUC(0.995) for differentiating patients from controls with an accuracy of 96.9%. The cut-off ADC used to differentiate early fibrosis from late fibrosis was 1.54 × 10^(-3) mm^2/s with an AUC of 0.866. The combination of ADC and miR-200 b revealed the best AUC(0.925) for differentiating early fibrosis from late fibrosis with an accuracy of 80.2%. The ADC correlated with miR-200 b(r =-0.61, P = 0.001), miR-21(r =-0.62, P = 0.001), and miR-29(r = 0.52,P = 0.001).CONCLUSION Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C. | Tarek Besheer Hatem Elalfy Mohamed Abd El-Maksoud Ahmed Abd El-Razek Saher Taman Khaled Zalata Wagdy Elkashef Hossam Zaghloul Heba Elshahawy Doaa Raafat Wafaa Elemshaty Eman Elsayed Abdel-Hady El-Gilany Mahmoud El-Bendary | 2019 | World Journal of Gastroenterology2019，25，11： | 9 |
| 2 | HydPophohically Modified Hydroxyethyl Starch: Synthesis, Characterization, and Aqueous Self - as - Sembly into Nano - Sized Polymeric Micelles and Vesicles 显示文摘 | Besheer A Hause G Mader K | 2007 | Biomacromoleeules2007，8，2： | 1 |
| 3 | Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study ' recognition memory' 显示文摘 | Bevins RA Besheer J | 2006 | Nat Protoe2006，1，3： | 1 |
| 4 | Object recognition in rats and mice:a onetrial non-matching to-sample learning task to study ' recognition memory'显示文摘 | Bevins RA Besheer J | | 0，，： | 1 |
| 5 | Hydrophobically modified hydroxyethyl starch: Synthesis, characterization, and aqueous self-assembly into nano-sized polymeric micelles and vesicles显示文摘 | Ahmed Besheer Gerd Hause | 2007 | Biota2007，8，： | 1 |
| 6 | Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring(P)rats显示文摘 | Besheer J Faccidomo S Grondin JJ | | 0，，： | 1 |
| 7 | Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens显示文摘 | Besheer J Grondin JJ Sailing MC | | 0，，30： | 1 |
| 8 | Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanpl self-administration in a rat genetic model of high alcohol intake显示文摘 | Besheer J Grondin JJ Cannady R | | 0，，09： | 1 |
| 9 | Object recognition in rats and mice a one - trial non - matching - to - sample learning task to study recognition memory'显示文摘 | BEVINS R A BESHEER J | 2006 | Nat Protoc2006，1，3： | 1 |
| 10 | Ethanol-in duced alterations of c-Fos immunoreactivity in specific limbie brain regions following ethanol discrimination training 显示文摘 | Besheer J Schroeder J P Stevenson R A | 2008 | Brain Res2008，1232，： | 1 |
| 11 | Pharmecologieal and Anatomical Evidence for an Interaction Between mGluR5-and GABAA al-Containing Receptors in the Discriminative Stimulus Effects of Ethanol显示文摘 | BESHEER J HODGEL C W | 2005 | Neuropsychopharmaeology2005，30，： | 1 |
| 12 | Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'显示文摘 | Bevins RA Besheer J | 2006 | Nat Protoc2006，1，3： | 1 |
| 13 | Characterization of PLGA nanospheres stabilized with amphiphilic polymers: hydrophohically modified hydroxyethyl starch vs pluronics显示文摘 | BESHEER A VOGEL J GLANZ D | 2009 | Pharmaceutics2009，6，2： | 1 |
| 14 | Object recognition in rats and mice: a one-trial non-matching- to-sample learning task to study ' recognition memory' 显示文摘 | Bevins R A Besheer J | 2006 | Nature Protocol2006，1，： | 1 |
| 15 | Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study ' recognition memory' 显示文摘 | Bevins R A Besheer J | 2006 | Nat Protoc2006，1，： | 1 |
| 16 | Influence of hydroxypropyl-beta-cyclodextrin on the stability of dilute and highly concentrated immunoglobulin G formulations 显示文摘 | H?rtl E Winter G Besheer A | 2013 | J Pharm Sci2013，102，11： | 1 |
| 17 | Hydrophobically modified hydroxyethyl starch:synthesis,characterization,and aqueous self-assembly into nano-sized polymeric micelles and vesicles显示文摘 | Hanse G Kressler J | 2007 | Biomacromolecules2007，8，2： | 1 |
| 18 | Object recognition in rats and mice : a one-trial non-matching- to-sample learning task to study ' recognition memory' 显示文摘 | Bevins R A Besheer J | 2006 | Nature Protocol2006，1，： | 1 |
| 19 | Hydrophobically Modified Hydroxyethyl Starch: Synthesis, Characterization and Aqueous Self-Assembly into Nano-Sized Polymeric Micelles and Vesicles显示文摘 | Besheer A Hause G Kressler J Mader K | 2007 | Biomacromolecules2007，8，： | 1 |
| 20 | 显示文摘 | Besheer A Vogel J Glanz D | 2009 | Molecular Pharmaceu- tics2009，6，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员