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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting : the clopidogrel aspirin stent international cooperative study (CLASSICS) 显示文摘 | RUPPRECHT HJ URBAN P | 2000 | Circulation2000，102，6： | 1 |
| 3 | Management of acutecoronary syndromes:acutecoronary syndromes withoutper sistent ST segment elevation;rccomsendations of the Task Force of the Europe an Society of Cardiology显示文摘 | Bertrand ME Simoons ML Fox KA et a1 | 2000 | EurHeartJ2000，21，： | 1 |
| 4 | Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting:the clopidogrel aspirin stent international co-opreative study(CLASSICS)显示文摘 | Rupprecht HJ Urban P | 2000 | Circulation2000，102，6： | 1 |
| 5 | A meta-analysis of the renal safety of isosmolar iodixanol compared with low-osmolar contrast media显示文摘 | Mecullough P Bertrand ME Brinker JA | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 6 | Management of acute coronary syndromes:acute coronary syndromes with out persistent ST segment elevation:recommendation of the task force of the European Society of Cardiology显示文摘 | Bertrand ME Simoons ML Fox KA et a1 | 2000 | Eur Heart J2000，2，17： | 1 |
| 7 | A meta-analysis of the renal safety of isosmolar iodixanol compared with low-os- molar contrast media 显示文摘 | McCullough PA Bertrand ME Bfinker JA | 2006 | J Am Coil Cardiol2006，48，4： | 1 |
| 8 | Relation to restenosis after PTCA显示文摘 | Bertrand ME Lablanche JM Fourrier JL | 1989 | Am J Cardiol1989，63，： | 1 |
| 9 | Routine upstream initiation vs deferred selective use of glycoprotein Ⅱb/Ⅲa inhibitors in acute coronary syndromes:The ACUITY timing trial显示文摘 | Stone GW Bertrand ME Moses JW | 2007 | JAMA2007，297，6： | 1 |
| 10 | Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combina- tion with aspirin after coronary stenting: the clopidogrel aspirin stent international cooperative study ( CLASSICS ) 显示文摘 | Bertrand ME Rupprecht HJ Urban P | 2000 | Circula- tion2000，102，6： | 1 |
| 11 | Management of acute coronary syndromes: acute coronary syndromes without persistent ST segment elevation: recommendation of the task force of the European Society of Cardiology显示文摘 | Bertrand ME Simoons ML Fox KA | 2000 | Eur Heart J2000，21，17： | 1 |
| 12 | Management of acute coronary syndromes:acute coronary syndromes without persistent ST segment elevation;recommendations of the Task Force of the European Society of Cardiology显示文摘 | Bertrand ME Simoons ML Fox KA | 2000 | Eur Heart J2000，21，17： | 1 |
| 13 | Management of acute coronary syndromes:acute coronary syndromes without persistent ST segment elevation:recommendations of the TaSk Force of the European Society of Cardiology显示文摘 | Bertrand ME Simoons ML Fox KA | 2000 | Eur Heart J2000，21，17： | 1 |
| 14 | Management of acute coronary syndromes in patients presenting without persistent ST-segment elevation显示文摘 | Bertrand ME Simoons ML Fox KA | 2002 | Eur Heart J2002，24，12： | 1 |
| 15 | A meta-analysis of the renal safety of isosmolar iodixanol compared with low-osmolar contrast media显示文摘 | Mccullough PA Bertrand ME Brinker JA | 2006 | J Am Coll Cardiol2006，48，4： | 1 |
| 16 | Management of a- cute coronary syndromes:acute coronary syndromes without persistent ST segment elevation; recommendations of the Task Force of the European Society of Cardiology 显示文摘 | Bertrand ME Simoons ML Fox KA | 2000 | Eur Heart J2000，21，17： | 1 |
| 17 | Optimization of the conditions for preservation of induced sputum: influence of freezing on cellular analysis显示文摘 | Prince P Bertrand M Boulay ME | 2005 | Chest2005，128，： | 1 |
| 18 | Provision of cardiovascular protection by ACE inhibitors: a review of recent trials显示文摘 | Bertrand ME | 2004 | Curr Med Resopin2004，20，10： | 1 |
| 19 | A meta- analysis of the renal safety of isosmolar iodixanol com- pared with low-osmolar contrast media显示文摘 | McCullongh PA Bertrand ME Brinker JA | 2006 | J Am Coil Car- diol2006，48，4： | 1 |
| 20 | Managementofacute coro- nary syndromes: acute coronary syndrowithout persistent ST seg- ment elevation: recommendations of the Task Force of the European Society of Cardiology显示文摘 | Bertrand ME Simoons ML Fox KA | 2000 | Eur Heart J2000，21，17： | 1 |
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