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| 1 | Endothelial dysfunction as a predictor of cardiovascular disease in type 1 diabetes显示文摘Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes(T1DM).Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes,a cause-effect relationship is less clear in T1 DM.Although endothelial dysfunction(ED) precedes atherosclerosis,it is not clear weather,in recent onset T1 DM,it may progress to clinical macrovascular disease.Moreover,endothelial dysfunction may either be reversed spontaneously or in response to intensive glycemic control,long-term exercise training and use of statins.Acute,long-term and post-prandial hyperglycemia as well as duration of diabetes and microalbuminuria are all conditions associated with ED in T1 DM.The pathogenesis of endothelial dysfunction is closely related to oxidative-stress.NAD(P)H oxidase over activity induces excessive superoxide production inside the mitochondrial oxidative chain of endothelial cells,thus reducing nitric oxide bioavailability and resulting in peroxynitrite formation,a potent oxidant agent.Moreover,oxidative stress also uncouples endothelial nitric oxide synthase,which becomes dysfunctional,inducing formation of superoxide.Other important mechanisms are the activation of both the polyol and protein kinase C pathways as well as the presence of advanced glycation end-products.Future studies are needed to evaluate the potential clinical applicability of endothelial dysfunction as a marker for early vascular complications in T1 DM. | Marcello C Bertoluci Gislaine V Cé Antonio MV da Silva Marco V Wainstein Winston Boff Marcia Punales | 2015 | World Journal of Diabetes2015，6，5： | 5 |
| 2 | Angiographic coronary artery disease is associated with progressively higher levels of fasting plasma glucose显示文摘 | Quadros AS Sarmento-Leite R Bertoluci M | 2007 | Diabetes Res Clin Pract2007，75，2： | 1 |
| 3 | Increased renal GLUT1 abundance and urinary TGFβ1 in streptozotocin-induced diabetic rats:implications for the development of nephropathy complicating diabetes显示文摘 | D'Agord Schaan B Lacchini S Bertoluci M C | 2001 | Horm Metab Res2001，33，11： | 1 |
| 4 | Serotonin and hypothalamiccontrol of hunger : a review 显示文摘 | Feij6Fde M Bertoluci MC Reis C | 2011 | Rev Assoc Med Bras2011，57，1： | 1 |
| 5 | Insulin resistance and triglyeeride/HDLc index are associated with coronary artery disease显示文摘 | BERTOLUCI M C QUADROS A S SARMENTO LEITE R | 2010 | Diabetol Metal) Syndr2010，3，2： | 1 |
| 6 | Simultaneous determination of cefepime, vancomycin and imipenem in human plasma of burn patients by high-performance liquid chromatography显示文摘 | Lopez KJ Bertoluci DF Vicente KM | 2007 | J Chromatogr B Analyt Technol Biomed Life Sci2007，860，2： | 1 |
| 7 | Insulin resistance and triglyceride/HDLc index are associated with coronary artery disease显示文摘 | Bertoluci MC Quadros AS Sarmentoleite R | 2010 | Diabetology and Metabolic Syndrome2010，2，： | 1 |
| 8 | Insulin resistance and triglyceride/HDL-C index are associated with coronary artery disease显示文摘 | Bertoluci M C Quadros A S Sarmentoleite R | 2010 | Diabetology and Metabolic Syndrome2010，21，2： | 1 |
| 9 | Insulin resistance and triglyceride/HDLc index are asso- ciated with coronary artery disease 显示文摘 | Bertoluci M C QUadros A S Sarmento-Leite R | 2010 | Diabetol Metab Syndr2010，2，11： | 1 |
| 10 | Microalbuminuria is associated with impaired arterial and venous endotheli- urn-dependent vasodilation in patients with type 2 dia- betes显示文摘 | Silva A M Schaan B D Signori L U Plentz R D Moreno H Jr Bertoluci M C | 2010 | J Endocrinol Invest2010，33，： | 1 |
| 11 | Increased renal GLUT1 abundance and urinary TGFβ1 in streptozotocin induced diabetic rats:implications for the development of nephropathy complicating diabetes显示文摘 | D'Agord Schaan B Lacchini S Bertoluci MC | 2001 | Horm Metab Res2001，33，11： | 1 |
| 12 | Impact of renal denervation on renal content of GLUT1,albuminuria and urinary TGF-β1 in streptozotocin-induced diabetic rats显示文摘 | D'Agord Schaan B Lacchini S Bertoluci MC | | 0，，： | 1 |
| 13 | Angiographic coronary artery disease is associated with progressively higher levels of fasting plasma glucose显示文摘 | Quadros AS Sarmento-Leite R Bertoluci M | 2007 | Diabetes Res Clin Pract2007，75，2： | 1 |
| 14 | Increased renal GLUT1 abundance and urinary TGF-beta 1 in streptozotocin-induced diabetic rats:implications for the development of nephopathy complicating diabetes 显示文摘 | D'Agord Schaan B Lacchini S Bertoluci MC | 2001 | Horm Metab Res2001，33，11： | 1 |
| 15 | In-creased renal GLUT1 abundance and urinary TGF-beta 1 in streptozotocin-induced diabetic rats:implications for the develop ment of nephropathy complicating diabetes显示文摘 | BDA Schaan Lacchini S Bertoluci MC | | 0，，： | 1 |
| 16 | Increased renal GLUT1 abundance and urinary TGF-beta 1 in streptozotocin-induced diabetic rats: implications for the development of nephropathy complicating diabetes显示文摘 | D'Agord Schaan B Lacchini S Bertoluci MC | 2001 | Horm Metab Res2001，33，： | 1 |
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