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| 1 | Faecalibacterium prausnitzii and human intestinal health显示文摘 | S Miquel R Martín O Rossi LG Bermúdez-Humarán JM Chatel H Sokol M Thomas JM Wells P Langella | 2013 | Current Opinion in Microbiology2013，，： | 3 |
| 2 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 3 | Hospitalized Patients with Novel Influenza A (H1N1) Virus Infection - California, April-May, 2009显示文摘 | Louie J Winter K Harriman K Vugia D Glaser C Matyas B Schnurr D Guevara H Pan C Y Saguar E Berumen R Hunley E Messenger S Preas C Hatch D Chavez G Kriner P Lopez K Sunega D Rexin D Roach S Kempf J Gonzalez R Morgan L Barnes N Berm | 2009 | MMWR Morbidity and Mortality Weekly Report2009，，19： | 1 |
| 4 | Interstritial chemotherapy with drug polyer implants for the treatment of recurrent glioma显示文摘 | Berm H Mahaley Ms Jr Vick N A | 1991 | J Neurosurg1991，74，3： | 1 |
| 5 | Interstitial chemotherapy with drug polymer implants for the treatment of recurrent glioma 显示文摘 | Mahaley MS Jr Vick NA | 1991 | J Neurosurg1991，74，3： | 1 |
| 6 | Laparoscopic partial nephrectomy for renal tumor:single center experience comparing clamping and no clamping techniques of the renal vasculature显示文摘 | Guillonneau B Bermúdez H Gholami S | 2003 | J Urol2003，169，2： | 1 |
| 7 | Intersitial Chemotherapy with Drug Polymer Implants for the Treatment of Recurrent Gliomas显示文摘 | Berm H Mahalty M S Nichola A V | 1991 | J Neurosurg1991，，74： | 1 |
| 8 | Interstitial chemotherapy with drug polymer implant for the treament of recurrent glioma 显示文摘 | Berm H Mahaley S Nichalas | 1991 | J Neurosury1991，74，6： | 1 |
| 9 | Placebo-controlled trial of safety and efficafy of intraopertive controlled delivery by biogradable polymers of chemotherapy for recurrent gliomas 显示文摘 | Berm H Piantadosi S Burger PC | 1995 | Lancet1995，345，8956： | 1 |
| 10 | Down syndrome screening in the first and/or second trimester: model predicted performance using meta - analysis parameters显示文摘 | Cuckle H Berm P W rigbt D | 2005 | Semin Perinatol2005，29，4： | 1 |
| 11 | Ocean acidifica- tion-induced food quality deterioration constrains trophic transfer 显示文摘 | ROSSOLL D BERM HDEZ R HAUSS H | 2012 | PLoS ONE2012，7，34： | 1 |
| 12 | Manufacture and application of high nitrogen steels显示文摘 | Berms H | 1996 | ISIJ Intemational1996，36，7： | 1 |
| 13 | Insecticidal flavaglines and other compounds from Fijian Aglaia species显示文摘 | Greger H Pacher T Berm B | 2001 | Phytochemistry2001，57，： | 1 |
| 14 | Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas显示文摘 | Berm H Mahaley MS Jr Vick NA | 1991 | J Neurosurg1991，74，3： | 1 |
| 15 | Ocean acidification-induced food quality deterioration constrains trophic transfer显示文摘 | Rossoll D Bermúdez R Hauss H | 2012 | PLoS one2012，7，34： | 1 |
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