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21篇 您的检索式：作者名="Bergthaller"

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	题名	作者	年代	出处	被引量
1	AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer.	Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger	2019	Cell Research2019，29，7：	2
2	Comparative study of pilot scale rice starch production by an alkaline and an enzymatic process显示文摘	Puchongkavarin H Varavinit S Bergthaller W	2005	Starch/Starke2005，，57：	1
3	Potato StarchTechnology显示文摘	Bergthaller W Witt W Goldau H P	1999	Starch/Starke1999，51，7：	1
4	Recovery of an arenavirus entirely from RNA polymerase Ⅰ/Ⅱ-driven cDNA显示文摘	Flatz L Bergthaler L de la Torre JC	2006	Proc Natl Acad Sci USA2006，103，12：	1
5	Compara- tive study of pilot scale rice starch production by an alka- line and an enzymatic process 显示文摘	Puchongkavarin H Varavinit S Bergthaller W	2005	Starch/Starke2005，57，：	1
6	Processing and characterization of biodegradable products based on starch显示文摘	W Bergthaller M G Lindhauer U Funke	1998	Ploymer Degradation and Stability1998，59，13：	1
7	Processing and characterization of biodegradable products based onstarch显示文摘	Bergthaller F W Lindhauer M G	1998	Polymer Degradation and Stability1998，59，13：	1
8	Recovery of an arenavirus entirely from RNA polymerase I / II -driven cDNA显示文摘	Flatz L Bergthaler A de la Tone JC	2006	Proe Natl Aead Sei USA2006，103，12：	1
9	Processing and characterization of biodegradable products based on starch显示文摘	Funke U Bergthaller W Lindhauer M G	1998	Polymer Degradation and Stability1998，，59：	1
10	Compar- ative study of pilot scale rice starch production by an alkaline and an enzymatic process显示文摘	Puchongkavarin H Varavinit S Bergthaller W	2005	Starch/Starke2005，57，：	1
11	Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3 + T-bet + Cell Subset with Combined Th2 and Th1 Cell Functions显示文摘	Ahmed N. Hegazy Michael Peine Caroline Helmstetter Isabel Panse Anja Fr?hlich Andreas Bergthaler Lukas Flatz Daniel D. Pinschewer Andreas Radbruch Max L?hning	2010	Immunity2010，，1：	1
12	Processing and characterization of biodegradable products based on starch显示文摘	Funke U Bergthaller W Lindhauev M G	1998	Polymer Degradable Stability1998，59，：	1
13	Comparative study of pilot scale rice starch production by an alkaline and an enzymatic process显示文摘	Puchongkavarin H Varavinit S Bergthaller W		0，，57：	1
14	Neuropmteetive intervention by interferon-3' blockade prevents CDs : T cell- mediated dendrite and synapse loss 显示文摘	Kreutzfeldt M Bergthaler A Femandez M	2013	J Exp Med2013，210，10：	1
15	Processing and characterization of biodegradable products based on starch显示文摘	U Funke W Bergthaller M G Lindhauer	1998	Polym Degrad Stab1998，59，：	1
16	The Imaging Sci J显示文摘	Bergthaller P	2002	50:2332002，50，：	1
17	Recovery of an arenavirus entirely from RNA polymerase Ⅰ/Ⅱ driven cDNA显示文摘	FLATZ L BERGTHALER A DE LA TORRE J C	2006	Proc Natl Acad Sci USA2006，103，12：	1
18	Coupler in colour photography-chemistry and function Part 3 显示文摘	P Bergthaller	2002	The imaging Science Journal2002，，2：	1
19	Comparative study of pilot scale rice starch production by an alkaline and an enzymatic process显示文摘	Puchongkavarin H Varavinit S Bergthaller W	2005	Starch/Starke2005，57，：	1
20	Starch from Alberta potatoes:Wet-isolation and some physicochemical properties显示文摘	Vasanthan T Bergthaller W Driedger D		0，，05：	1

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