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| 1 | Predictive factors of histological response of colorectal liver metastases after neoadjuvant chemotherapy显示文摘BACKGROUND Colorectal cancer is the third most common cancer in men and the second most common in women worldwide. Almost a third of the patients has or will develop liver metastases. Neoadjuvant chemotherapy(NAC) has recently become nearly systematic prior to surgery of colorectal livers metastases(CRLMs). The response to NAC is evaluated by radiological imaging according to morphological criteria.More recently, the response to NAC has been evaluated based on histological criteria of the resected specimen. The most often used score is the tumor regression grade(TRG), which considers the necrosis, fibrosis, and number of viable tumor cells.AIM To analyze the predictive factors of the histological response, according to the TRG, on CRLM surgery performed after NAC.METHODSFrom January 2006 to December 2013, 150 patients who had underwent surgery for CRLMs after NAC were included. The patients were separated into two groups based on their histological response, according to Rubbia-Brandt TRG.Based on their TRG, each patient was either assigned to the responder(R) group(TRG 1, 2, and 3) or to the non-responder(NR) group(TRG 4 and 5). All of the histology slides were re-evaluated in a blind manner by the same specialized pathologist. Univariate and multivariate analyses were performed.RESULTS Seventy-four patients were classified as responders and 76 as non-responders.The postoperative mortality rate was 0.7%, with a complication rate of 38%.Multivariate analysis identified five predictive factors of histological response.Three were predictive of non-response: More than seven NAC sessions, the absence of a radiological response after NAC, and a repeat hepatectomy(P <0.005). Two were predictive of a good response: A rectal origin of the primary tumor and a liver-first strategy(P < 0.005). The overall survival was 57% at 3 yr and 36% at 5 yr. The disease-free survival rates were 14% at 3 yr and 11% at 5 yr.The factors contributing to a poor prognosis for disease-free survival were: No histological response after NAC, largest metastasis > 3 cm, more than three preoperative metastases, R1 resection, and the use of a targeted therapy with NAC(P < 0.005).CONCLUSION A non-radiological response and a number of NAC sessions > 7 are the two most pertinent predictive factors of non-histological response(TRG 4 or 5). | Chloé Serayssol Charlotte Maulat Florence Breibach Fatima-Zohra Mokrane Janick Selves Rosine Guimbaud Philippe Otal Bertrand Suc Emilie Berard Fabrice Muscari | 2019 | World Journal of Gastrointestinal Oncology2019，11，4： | 4 |
| 2 | Epidemiology and Treatment Costs of Bone Metastases from Lung Cancer: A French Prospective, Observational, Multicenter Study (GFPC 0601)显示文摘 | Chantal Decroisette Isabelle Monnet Henri Berard Gilles Quere Herve Le Caer Suzanna Bota Clarisse Audigier-Valette Laurence Geriniere Jean-Marc Vernejoux Christos Chouaid | 2011 | Journal of Thoracic Oncology2011，，3： | 2 |
| 3 | High-cycle fatigue crack initiation and propagation behaviour of high strength spring steel wires 显示文摘 | Berard J Y Bathias C | 1999 | Fatigue and Fracture of Engineering Materials and Structures1999，22，： | 1 |
| 4 | Impairment of the intestinal barrier by ethanol involves enteric microflora and mast cell activation in rodents显示文摘 | Ferrier L Berard F Debrauwer L | 2006 | AmJ Pathol2006，168，4： | 1 |
| 5 | Hemophagocytic syndrome in patients with acute myeloid leukemia undergoing intensive chemotherapy显示文摘 | Delavigne K Berard E Bertoil S | 2014 | Heamatologica2014，99，： | 1 |
| 6 | Irrigation frequency and quantity affect root and top growth of fertigated McIntosh apple on M9,M6 and M7 rootstock显示文摘 | Neilsen G H Parchomchuk P Berard R | 1997 | Canadian Jouranl of Plant Science1997，77，： | 1 |
| 7 | Dynamic imaging of transient metabolic processes by small-animal PET for the evaluation of photosensitizers in photodynamic therapy of cancer 显示文摘 | Berard V Rousseau JA Cadorette J | 2006 | J Nucl Med2006，47，7： | 1 |
| 8 | Patellar instability in children and adolescents 显示文摘 | Chotel F Berard J Raux S | 2014 | Orthop Traumatol Surg Res2014，，1： | 1 |
| 9 | T-cell recognition of prostatic peptides in men with chronic prostatitis/chronic pelvic pain syndrome显示文摘 | Kouiavskaia DV Southwood S Berard CA | | 0，，5： | 1 |
| 10 | Vascular endothelial growth factor confers a growth advantage in vitro and invivo to stromal cells cultured from neonatal hemangiomas显示文摘 | Berard M Sordello S Ortega N | 1997 | Am J Pathol1997，150，： | 1 |
| 11 | Profiles and prognostic values of LDH isoenzymes in patients with non-Hodgkin's lymphoma显示文摘 | DUMONTET C BIENVENT J BERARD EN | 1999 | Leukemia1999，13，5： | 1 |
| 12 | Impact of chronic and acute pesticide exposures on periphyton communities显示文摘 | Tlili A Montuelle B Berard A | 2011 | Sci Total Environ2011，409，11： | 1 |
| 13 | Effects of dietary L-arginine sup- plementation to gilts during early gestation on foetal survival, growth and myofiber formation显示文摘 | BERARD J BEE G | 2010 | Animal2010，4，10： | 1 |
| 14 | Quantitative proteomic analyses of influenza virus-infected cultured human lung cells 显示文摘 | Coombs K M Berard A Xu W | 2010 | J Virol2010，84，10： | 1 |
| 15 | Corona discharges in atmospheric air between a wire and two plates显示文摘 | Berard P Lacoste D A Laux C O | 2011 | IEEE Transactions on Plasma Science2011，39，11： | 1 |
| 16 | Hihg-cycle fatigue crack initiation and propagation behavior of high-strength spring stell wires 显示文摘 | Wang Q Y Berard J Y Bathias C | 1999 | Fatigue Fraet Engng Mater Struct1999，22，8： | 1 |
| 17 | Socity for hematopathology program,proposed world health organization classification of neoplastic disease of hematopoietic and lymphoid tissue显示文摘 | Jaffe ES Berard CW Harris NL | 1997 | Am J Surg Pathol1997，21，1： | 1 |
| 18 | Cross-priming of naive CD8 + T cells against melanoma antigens using dendritic cells loaded with killed allogeneic melanoma cells显示文摘 | Blanco P Davoust J | 2000 | J Exp Med2000，192，： | 1 |
| 19 | Clinical assessment of spasticity in children显示文摘 | Vadot JP Berard C | 2003 | Neurochirurgie2003，49，232： | 1 |
| 20 | Transcriptional Activation of Apolipoprotein CIII Expression by Glucose May Contribute to Diabetic Dyslipidemia显示文摘 | Sandrine Caron An Verrijken Ilse Mertens Carolina Huaman Samanez Gisèle Mautino Joel T. Haas Daniel Duran-Sandoval Janne Prawitt Sven Francque Emmanuelle Vallez Anne Muhr-Tailleux Isabelle Berard Folkert Kuipers Jan A. Kuivenhoven Sudha B. Biddinger Marja | 2011 | Arteriosclerosis Thrombosis and Vascular Biology2011，，3： | 1 |
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