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| 1 | Artificial intelligence in gastroenterology: A state-of-the-art review显示文摘The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical specialties.The field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an exception.The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic examination.The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field. | Paul T Kröner Megan ML Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong | 2021 | World Journal of Gastroenterology2021，27，40： | 6 |
| 2 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 3 | Intrahepatic IL-8 producing Foxp3 + CD4 + regulatory T cells and fibrogenesis in chronic hepatitis C<!-- Doctopic: VH -->显示文摘 | Bettina Langhans Benjamin Kr?mer Marcell Louis Hans Dieter Nischalke Robert Hüneburg Andrea Staratschek-Jox Margarethe Odenthal Steffen Manekeller Michael Schepke J?rg Kalff Hans-Peter Fischer Joachim L. Schultze Ulrich Spengler | 2013 | Journal of Hepatology2013，，2： | 1 |
| 4 | Impaired CD4 + T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients<!-- Doctopic: VH -->显示文摘 | Andreas Gl?ssner Marianne Eisenhardt Pavlos Kokordelis Benjamin Kr?mer Franziska Wolter Hans Dieter Nischalke Christoph Boesecke Tilman Sauerbruch Jürgen K. Rockstroh Ulrich Spengler Jacob Nattermann | 2013 | Journal of Hepatology2013，，： | 1 |
| 5 | The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients显示文摘 | Hans Dieter Nischalke Cordula Berger Carolin Luda Tobias Müller Thomas Berg Martin Coenen Benjamin Kr?mer Christian K?rner Jonel Trebicka Frank Grünhage Frank Lammert Jacob Nattermann Tilman Sauerbruch Ulrich Spengler | 2011 | Journal of Hepatology2011，，4： | 1 |
| 6 | Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range显示文摘 | Thomson TM Benjamin KR Bush A | 2011 | Proc Nail Acad Sci USA2011，108，20： | 1 |
| 7 | The BCI competition 2003: Progress and perspectives in detection and discrimination of EEG single trials显示文摘 | Benjamin B Muller KR Curio G | 2004 | IEEE Trans Biomed Eng2004，51，6： | 1 |
| 8 | Intrahepatic IL-8 producing Foxp3 + CD4 + regulatory T cells and fibrogenesis in chronic hepatitis C显示文摘 | Bettina Langhans Benjamin Kr?mer Marcell Louis Hans Dieter Nischalke Robert Hüneburg Andrea Staratschek-Jox Margarethe Odenthal Steffen Manekeller Michael Schepke J?rg Kalff Hans-Peter Fischer Joachim L. Schultze Ulrich Spengler | 2013 | Journal of Hepatology2013，，2： | 1 |
| 9 | Impaired CD4 + T cell stimulation of NK cell anti-fibrotic activity may contribute to accelerated liver fibrosis progression in HIV/HCV patients显示文摘 | Andreas Gl?ssner Marianne Eisenhardt Pavlos Kokordelis Benjamin Kr?mer Franziska Wolter Hans Dieter Nischalke Christoph Boesecke Tilman Sauerbruch Jürgen K. Rockstroh Ulrich Spengler Jacob Nattermann | 2013 | Journal of Hepatology2013，，： | 1 |
| 10 | Ligase chain reaction显示文摘 | Benjamin WH Jr Smith KR Waites KB | 2003 | Methods Mol Biol2003，226，： | 1 |
| 11 | The ratio of calprotectin to total protein as a diagnostic and prognostic marker for spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites显示文摘 | Philipp Lutz Kenneth Pfarr Hans Dieter Nischalke Benjamin Kr?mer Felix Goeser Andreas Gl?ssner Franziska Wolter Pavlos Kokordelis Jacob Nattermann Tilman Sauerbruch Achim Hoerauf Christian P. Strassburg Ulrich Spengler | 2015 | Clinical Chemistry and Laboratory Medicine (CCLM)2015，，12： | 1 |
| 12 | Angiotensin‐II type 1 receptor‐mediated Janus kinase 2 activation induces liver fibrosis显示文摘 | Michaela Granzow Robert Schierwagen Sabine Klein Benita Kowallick Sebastian Huss Markus Linhart Irela G. Reza Mazar Jan G?rtzen Annabelle Vogt Frank A. Schildberg Maria A. Gonzalez‐Carmona Alexandra Wojtalla Benjamin Kr?mer Jacob Nattermann S?ren V. Siegm | 2014 | Hepatology2014，，1： | 1 |
| 13 | Numerical investigation of the dynamics of a rigidspherical particle in a vortical cross-slot flow atmoderate inertia显示文摘The study of flow and particle dynamics in microfluidic cross-slot channels is of high relevance for lab-on-a-chipapplications. In this work, we investigate the dynamics of a rigid spherical particle in a cross-slot junction for a channelheight-to-width ratio of 0.6 and at a Reynolds number of 120 for which a steady vortex exists in the junction area.Using an in-house immersed-boundary-lattice-Boltzmann code, we analyse the effect of the entry position of theparticle in the junction and the particle size on the dynamics and trajectory shape of the particle. We find that thedynamics of the particle depend strongly on its lateral entry position in the junction and weakly on its vertical entryposition;particles that enter close to the centre show trajectory oscillations. Larger particles have longer residencetimes in the junction and tend to oscillate less due to their confinement. Our work contributes to the understanding ofparticle dynamics in intersecting flows and enables the design of optimised geometries for cytometry and particlemanipulation. | Konstantinos Kechagidis Benjamin Owen Lionel Guillou Henry Tse Dino Di Carlo Timm Krüger | 2023 | Microsystems & Nanoengineering2023，9，4： | 0 |
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