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| 1 | Artificial intelligence in gastroenterology: A state-of-the-art review显示文摘The development of artificial intelligence(AI)has increased dramatically in the last 20 years,with clinical applications progressively being explored for most of the medical specialties.The field of gastroenterology and hepatology,substantially reliant on vast amounts of imaging studies,is not an exception.The clinical applications of AI systems in this field include the identification of premalignant or malignant lesions(e.g.,identification of dysplasia or esophageal adenocarcinoma in Barrett’s esophagus,pancreatic malignancies),detection of lesions(e.g.,polyp identification and classification,small-bowel bleeding lesion on capsule endoscopy,pancreatic cystic lesions),development of objective scoring systems for risk stratification,predicting disease prognosis or treatment response[e.g.,determining survival in patients post-resection of hepatocellular carcinoma),determining which patients with inflammatory bowel disease(IBD)will benefit from biologic therapy],or evaluation of metrics such as bowel preparation score or quality of endoscopic examination.The objective of this comprehensive review is to analyze the available AI-related studies pertaining to the entirety of the gastrointestinal tract,including the upper,middle and lower tracts;IBD;the hepatobiliary system;and the pancreas,discussing the findings and clinical applications,as well as outlining the current limitations and future directions in this field. | Paul T Kröner Megan ML Engels Benjamin S Glicksberg Kipp W Johnson Obaie Mzaik Jeanin E van Hooft Michael B Wallace Hashem B El-Serag Chayakrit Krittanawong | 2021 | World Journal of Gastroenterology2021，27，40： | 6 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | Prevalence, incidence,prognosis, and predisposing conditions for atrial fibrillation: population-based estimates显示文摘 | Kannel W B Wolf P A Benjamin E J | 1998 | Am J Cardiol1998，82，8： | 1 |
| 4 | Prevalence,incidence prognosis,and predisposing conditions for atrial fibrillation:population based estimates显示文摘 | Kannel W B Wolf P A Benjamin E J | 1998 | Am J Cardiol1998，82，8： | 1 |
| 5 | The bedside insertion of inferior vena cava filters using ultrasound guidance 显示文摘 | UPPAL B FLINN W R Benjamin M E | 2007 | Perspect Vasc Surg Endovasc Ther2007，19，1： | 1 |
| 6 | Impact of at- rial fibrillation on the risk of death: the Framingham Heart Study显示文摘 | Benjamin E J Wolf P A D' Agostino R B | 1998 | Circulation1998，98，10： | 1 |
| 7 | A simple model for complex dynamical transitions in epidemics显示文摘 | Pejman R Benjamin M B | 2000 | Science2000，287，： | 1 |
| 8 | Loran data modulation: extensions and examples显示文摘 | SHERMAN C L BENJAMIN B P Per K E | 2007 | IEEE Aerospace and Electronic Systems Magazine2007，43，2： | 1 |
| 9 | Current perceptions of the epidemiology of atrial fibrillation显示文摘 | KANNEL W B BENJAMIN E J | | 0，，1： | 1 |
| 10 | The disintegration of wave trains on deep water Part I:theory 显示文摘 | Benjamin T B Feir J E | 1967 | Journal of Flhid Mechanics1967，27，3： | 1 |
| 11 | Impact of atrial fibrillarion on the risk of death: the Framingham Heart Study显示文摘 | BENJAMIN E J WOKF P A AGOSTIO R B | 1998 | Circulation1998，98，： | 1 |
| 12 | Guidelines for the safe handling of hazardous drugs: consensus recommendations显示文摘 | Chaffee B W Armitstead J A Benjamin B E | 2010 | Am J Health Syst Pharm2010，67，18： | 1 |
| 13 | Comparison of crystal and solution structures and 1H-NMR and ^13C-NMR chemical shifts for grandiflorenic acid, and monoginoic acid 显示文摘 | Raul G E Jutie B Benjamin O | 1997 | Can J Chem1997，75，： | 1 |
| 14 | A sim-ple model for complex dynamical transitions in epi-demics显示文摘 | David J D E Pejman R Benjamin M B | 2002 | Science2002，287，： | 1 |
| 15 | Using GPS-IWV in a 4-D data assimilation system显示文摘 | SMITH T L BENJAMIN S G SHWARTZ B E | 2000 | Earth Plants Space2000，52，2： | 1 |
| 16 | Chronic exogenous kisspeptin administration accelerates gonadal development in basses of the genus Morone显示文摘 | Benjamin H B Adam F S Matthew E | | 0，，162： | 1 |
| 17 | The disintegration of wavetrains on deep water 显示文摘 | Benjamin T B J E Feir | 1967 | J Fluid Mech1967，27，： | 1 |
| 18 | Thenitrification index:a unified concept for quantifying therisk of distribution显示文摘 | SPEITEL Jr G E KANNAPPAN R BENJAMIN M B | 2011 | American Water WorksAssociation2011，103，1： | 1 |
| 19 | Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions;the Framingham Heart Study显示文摘 | Dhingra R Ho Nam B Benjamin E J | 2005 | J Am Coll Cardiol2005，45，5： | 1 |
| 20 | Impact of atrial fibrillation on the risk of death; the Framinghan heart study显示文摘 | BENJAMIN E J WOLF P A D'AGOSTINO R B | 1998 | Circulation1998，98，10： | 1 |
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