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| 1 | Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c显示文摘AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA. | Tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna | 2018 | World Journal of Hepatology2018，10，9： | 4 |
| 2 | Noninvasive scores for the prediction of esophageal varices and risk stratification in patients with cirrhosis显示文摘The primary purpose of variceal screening in patients with cirrhosis is to detect gastroesophageal varices at high risk of hemorrhage and implement preventative intervention(s).It was previously recommended that all patients with cirrhosis undergo initial and periodic longitudinal variceal screening via upper endoscopy.However,there has been growing interest and methods to identify patients with cirrhosis who may not have clinically significant portal hypertension and therefore be unlikely to have varices requiring intervention or benefit from upper endoscopy.Because the population of patients with compensated advanced chronic liver disease continues to grow,it is neither beneficial nor cost-effective to perform endoscopic variceal screening in all patients.Therefore,there is ongoing research into the development of methods to non-invasively risk stratify patients with cirrhosis for the presence of high-risk esophageal varices and effectively limit the population that undergoes endoscopic variceal screening.This is particularly important and timely in light of increasing healthcare reform and barriers to healthcare.In this review,we discuss and compare,with respect to test characteristics and clinical applicability,the available methods used to noninvasively predict the presence of esophageal varices. | Saroja Bangaru Jihane N Benhammou James H Tabibian | 2020 | World Journal of Hepatology2020，12，11： | 3 |
| 3 | Metal oxide nanoparticles for advanced energy applications显示文摘 | Lee S H Deshpande R Benhammou D | 2009 | Thin Solid Films2009，517，： | 1 |
| 4 | Adsorption of metal ions onto Moroccan stevensite: Kinetic and isotherm studies显示文摘 | Benhammou A Yaacoubi A Nibou L | 2005 | Colloid and Interface Science2005，282，2： | 1 |
| 5 | Cranio-cervical junction malformations : a rare cause of bilateral vocal cord paralysis 显示文摘 | Benhammou A Benbouzid MA Bencheikh R | 2007 | Ann Otolaryngol Chit Cervicofac2007，124，2： | 1 |
| 6 | Adsorption of metal ions onto Moroccan stevensite: Kinetic and isotherm studies 显示文摘 | Benhammou A Yaacoubi A Nibou L | 2005 | Journal of Colloid and Interface Science2005，282，2： | 1 |
| 7 | Smoking and schizophrenia:abnormal nicotinic receptor expression显示文摘 | Leonard S Bresse C Adams C Benhammou K Gault J Steven K Lee M Adler L Olincy A Ross R Freedman R | 2000 | Eur J Pharmacol2000，393，： | 1 |
| 8 | Papillary adeno- carcinoma on ectopic thyroid tissue 显示文摘 | Dib N Benhammou A Meziane M | 2009 | Ann Otolaryngol CHir Cervicofae2009，126，2： | 1 |
| 9 | Non-linear multivariable adaptive control of an activated sludge wastewater treatment process显示文摘 | NEJJARI F BENHAMMOU A DAHHOU B | 1999 | Int J Adapt Control Signal Process1999，13，5： | 1 |
| 10 | Smoking and mental illness显示文摘 | Leonard S Adler LE Benhammou K | 2001 | Pharmaeol Bioehem Behav2001，70，3： | 1 |
| 11 | Study of the removal of mercury( 1I ) and chromium ( VI ) from aqueous solu- tions by Moroccan stevensite显示文摘 | Benhammou A Yaacoubi A Nibou L et al | 2005 | Journal of Hazardous Materials2005，117，2： | 1 |
| 12 | Synthesis and characterization of cordierite ceramic from Moroccan stevensite and andalusite显示文摘 | R. Bejjaoui A. Benhammou L. Nibou B. Tanouti J.P. Bonnet A. Yaacoubi A. Ammar | 2010 | Applied Clay Science2010，，： | 1 |
| 13 | Metal oxide nanoparticles for advanced energy applications显示文摘 | Lee S H Deshpande R Benhammou D etal | 2009 | Thin Solid Films2009，517，： | 1 |
| 14 | Adsorption of metal ions onto Moroccan stevensite: kinetic and isotherm studies显示文摘 | Benhammou A Yaacoubi A Nibou L | 2005 | Journal of Collid and Interface Science2005，282，： | 1 |
| 15 | Smoking and mental illness显示文摘 | Leonard S Adler LE Benhammou K | 2001 | Pharmacol Biochem Behav2001，70，： | 1 |
| 16 | Study of the removal of mercury ( Ⅱ ) chromium ( Ⅵ ) from aqueous solutions by Moroccan stevensite 显示文摘 | Benhammou A Yaacoubi A Nibou L | 2005 | Journal of Hazardous Materials2005，117，213： | 1 |
| 17 | Papillary adenocarcinoma on ectopic thyroid tissue 显示文摘 | Dib N Benhammou A Meziane M | 2009 | Ann Otolaryngol Chir Cervicofac2009，126，2： | 1 |
| 18 | Chromium (Ⅵ) adsorption from aqueous solution onto Moroccan Al-pillared and cationic surfactant stevensite显示文摘 | Benhammou A Yaacoubi A Nibou L | 2007 | Hazard Mater2007，140，： | 1 |
| 19 | Smoking and mental illness 显示文摘 | Leonard S Adler LE Benhammou K | 2001 | Pharmaeol Biochem Behav2001，70，4： | 1 |
| 20 | The impact of germline BHD mutation on histological concordance and clinical treatment of patients with bilateral renal masses and known unilateral oncocytoma显示文摘 | Boris RS Benhammou J Merino M | 2011 | J Urol2011，185，6： | 1 |
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