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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Continuous High-Frequency Dissolved O-2/Ar Measurements by Equilibrator Inlet Mass Spectrometry 显示文摘 | Cassar N Barnett B A Bender M L | 2009 | Analytical Chemistry2009，81，5： | 1 |
| 3 | Using patch isolation metrics to predict animal movement in binary landscapes显示文摘 | BENDER D J TISCHENDORF L FAHRIG L | 2003 | Landscape Ecology2003，18，1： | 1 |
| 4 | Pseudomonas syringae phytotoxins:mode of action,regulation,and biosynthesis by peptide and polyketide synthetases显示文摘 | Bender C L Alarcon-Chaidez F Gross D C | | 0，，： | 1 |
| 5 | Lunar laser ranging:a c ontinuing legacy of the Apollo program显示文摘 | P L Bender J E Faller | 1994 | Science1994，265，： | 1 |
| 6 | Ostwald ripening of liquid phase sintered Cu-Co dispersions at high volume fractions 显示文摘 | Bender W Ratke L | 1998 | Aeta Mater1998，46，4： | 1 |
| 7 | MLSR: a novel routing algorithm for multilayered satellite IP networks显示文摘 | AKYILDIZ L F EKICI E BENDER M D | 2002 | IEEE/ACM Trans on Networking2002，10，3： | 1 |
| 8 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: suboxic diagenesis 显示文摘 | Froelieh P N Klinkhammer G P Bender M L Luedtke N A Heath G R Cullen D Dauphin P Hammond D Hartman B | 1979 | Geoehim Cosmoehim Acta1979，43，7： | 1 |
| 9 | A rechargeable room-temperature sodium superoxide (NaOz) battery显示文摘 | Hartmann P Bender C L Vracar M | 2013 | Nature Materials2013，12，3： | 1 |
| 10 | The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines显示文摘 | Gonzalgo M L Hayashida T Bender C M | 1998 | Cancer Res1998，58，6： | 1 |
| 11 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic:Suboxic diagenesis显示文摘 | Froelich P N Klinkhammer G P Bender M L | 1979 | Geochimica et Cosmochimica Acta1979，43，： | 1 |
| 12 | The distribution of manganese in the Pacific Ocean显示文摘 | Klinkhammer G P Bender M L | 1980 | Earth Planet Sci Lett1980，46，： | 1 |
| 13 | Dynamic processes observed at a gas hydrate outcropping onthe continental slope of the Gulf of Mexico显示文摘 | VARDARO M MACDONALD I BENDER L | 2006 | Geo-Mar Lett2006，26，1： | 1 |
| 14 | Hemiplegic shoulder pain: defining the problem and its management 显示文摘 | Bender L McKenna K | 2001 | Disabil Rehabil2001，23，16： | 1 |
| 15 | Early oxidation of organic matter in pelagic sediments of the eastern equatorial Atlantic: Suboxic diagenesis 显示文摘 | Froelieh P N Klinkhammer G P Bender M L Luedtke N A Heath G R Cullen D Dauphin P Hammond D Hartman B Maynard V | 1979 | Geochim Cosmochim Acta1979，43，7： | 1 |
| 16 | Purified chemicals and resins from Phenol and Formaldehyde显示文摘 | Bender H L Farnham A G Guyer J W | 1952 | Ind Engng Chem1952，44，6： | 1 |
| 17 | Two Arabidopsis methylation-deficiency muta- tions confer only partial effects on a methylated endogenous gene family显示文摘 | Bartee L Bender J | 2001 | Nucleic Acids Res2001，29，10： | 1 |
| 18 | Habitat loss and population decline: A meta-analysis of the patch size effect显示文摘 | Bender D J Contreras T A Fahring L | 1998 | Ecology1998，79，2： | 1 |
| 19 | Toward better sodium-oxygen batteries: A study on the performance of engineered oxygen electrodes based on carbon nanotubes 显示文摘 | Bender C L Bartuli W Schwab M G | 2015 | Energy Technology2015，3，3： | 1 |
| 20 | Roles of 17ss-estradiol in-volve regulation of reelin expression and synaptogenesis in the den-tate gyrus显示文摘 | Bender RA Zhou L Wilkars W | 2010 | Cereb Cortex2010，20，： | 1 |
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