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	题名	作者	年代	出处	被引量
1	Endothelial adhesion of synchronized gastric tumor cells changes during cell cycle transit and correlates with the expression level of CD44 splice variants显示文摘AIM: To study adhesion capacity and CD44 expression of human gastric adenocarcinoma MKN45 cells at different stages of a first cell cycle.METHODS: MKN45 cells were synchronized by aphidicolin and assayed for adhesion to an endothelial cell (HUVEC)monolayer. Surface expression of CD44 and CD44 splice variants on MKN45 cells was evaluated by flow cytometry.Functional relevance of CD44 adhesion receptors was investigated by blocking studies using anti CD44 monoclonal antibodies or by hyaluronan digestion.RESULTS: Adhesion of MKN45 to HUVEC was increased during G2/M transit, after which adhesion returned to baseline levels with cell cycle completion. In parallel, CD44splice variants CD44v4, CD44v5, and CD44v7 were all upregulated on MKN45 during cell cycle progression with a maximum effect in G2/M. The function of CD44 surface receptors was assessed with specific receptor blocking monodonal antibodies or removal of hyaluronan by digestion with hyaluronidase. Both strategies inhibited tumor cell adhesion to HUVEC by nearly 50%, which indicates that MKN45-HUVEC-interaction is CD44 dependent.CONCLUSION: CD44 expression level is linked to the cell cycle in gastrointestinal tumor cells, which in turn leads to cell cyde dependent alterations of their adhesion behaviour to endothelium.	Anton Oertl Jens Castein Tobias Engl Wolf-Dietrich Beecken Dietger Jonas Richard Melamed Roman A. Blaheta	2005	World Journal of Gastroenterology2005，11，40：	3
2	Radiation therapy to primary tumoRaccelerates metastatic growth in mice显示文摘	Camphausen K Moses M A Beecken W D	2001	CanceRResearch2001，61，5：	1
3	Roboticassisted laparoscopic radical cystectomy and intraabdominal formation of an orthotopic ileal neobladder显示文摘	BEECKEN WD WOLFRAM M ENGL T	2003	Eur Urol2003，44，：	1
4	New molecular mediators in tumor angiogenesis显示文摘	Beecken W D Kramer W Jonas D		0，，04：	1
5	Radiation therapy to a primary tumor accelerates metastatic growth in mice 显示文摘	Camphausen K Mose M A Beecken W D	2001	Cancer Res2001，61，5：	1
6	Effect of angiostatinic therapy on slowly growing,poorly vascularized tumors in mice显示文摘	Fernandez A Joussen AM	2001	J Natl Cancer Inst2001，93，5：	1
7	Plasmin-clipped beta(2)-glycoprotein-I inhibits endothelial cell growth by down-regulating cyclin A,B and D1 and up-regulating p21 and p27显示文摘	Beecken WD Ringel EM Babica J	2010	Cancer Lett2010，296，2：	1
8	Expression of angiogenesis inhibitors in human bladder cancer may explain rapid metastatic progression after radical cystectomy显示文摘	Beecken WD Engl T Jonas D	2009	Int J Mol Med2009，23，2：	1
9	Expression of angiogenesis inhibitors in human blader cancer may explain rapid metastatic progression after radical eystectomy显示文摘	Beecken WD Engl T Jonas D	2009	lnt J Moled2009，23，2：	1
10	Robticassisted laparoendoscopic radical cystectomy and intraabdominl formation of an orthotopic ileal neobladder显示文摘	Beecken WD Wolfram M Engl T	2003	Eur Urol2003，44，3：	1
11	New molecular mediators in tumor angiogenesis显示文摘	Beecken WD Kramer W Jonas D	2001	Cell Mol Med2001，4，4：	1
12	New molecular mediators in tumor angiogenesis 显示文摘	Beecken WD Kramer W Jonas D	2000	J Cell Mol Med2000，4，4：	1
13	Radiation therapy to a primary tumor accelerates metastatic growth in mice显示文摘	Camphausen K Moses MA Beecken WD	2001	Cancer Res2001，61，5：	1
14	Robotic- assisted laparoscopic radical cystectomy and intra-abdominal formation of an orthotopic ileal neobladder显示文摘	BEECKEN W D WOLFRAM M ENGL T	2003	Eur Urol2003，44，3：	1
15	Robotic-assisted laparoscopic radical cystectomy and intra-abdominal formation of an orthotopic ileal neobladder显示文摘	Beecken WD Wolfram M Engl T	2003	Eur Urol2003，44，3：	1
16	Robotic--assisted laparoscopic radical cystectomy and intra--abdominal formation of an orthotopic ileal neobladder显示文摘	Beecken WD Wolfram M Engl T	2003	Eur Urol2003，44，：	1
17	Clinilal relevance of maspin expression in bladder cancer显示文摘	Beecken WD	2006	World J Urol2006，24，：	1
18	Radiation therapy to a primary tumor accelerates metastatic growth in mice显示文摘	Camphausen K Moses MA Beecken WD	2001	Cancer Res2001，61，5：	1
19	Robotic-assisted laparoscopic radical cystectomy and intra-abdominal formation of an orthotopic ileal neobladder 显示文摘	BEECKEN WD WOLFRAM M ENGL T	2003	Eur Urol2003，44，3：	1
20	Clinical relevance of Maspin expression in bladder cancer 显示文摘	Wolf D Beecken Tobias Engl	2006	Worht J Urol2006，24，：	1

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