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| 1 | Role of receptor tyrosine kinases in gastric cancer: New targets for a selective therapy显示文摘受体酷氨酸家族 ases (RTK ) 象表皮的生长因素受体家庭那样包括增长和变形传播参予肿瘤形成的几步。几已知的 RTK 起来在是主要的胃的癌症调整了定制的治疗的目标。仅仅初步的数据然而,在使用上存在当前临床上可得到的药象在胃的癌症的背景的 trastuzumab, cetuximab, bevacizumab, gefitinib, erlotinib,和 imatinib 那样。现出症状之前的潜的数据建议他们的使用的一个潜在的好处,特别在有“常规”的抑制细胞的联合治疗。这评论象新途径和药一样在癌症治疗关于他们的使用总结当前的知识优化治疗成功。 | JC Becker C Müller-Tidow H Serve W Domschke T Pohle | 2006 | World Journal of Gastroenterology2006，12，21： | 19 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Evaluating the performance of biologically active rapid filters 显示文摘 | Lechevallier M W William C Becker Paul Schorr | 1992 | J AWWA1992，84，4： | 2 |
| 4 | Kontrastmittelsonografie bei B-Bild-morphologisch unklaren Leberraumforderungen – Diagnostische Treffsicherheit im klinischen Alltag (DEGUM-Multicenter – Studie)显示文摘 | D Strobel K Seitz W Blank A Schuler C Dietrich A Herbay M Friedrich-Rust G Kunze D Becker U Will W Kratzer F Albert C Pachmann K Dirks H Strunk C Greis T Bernatik | 2008 | Ultraschall in Med2008，，05： | 2 |
| 5 | CT of coronary artery disease显示文摘 | SCHOEPF U J BECKER C R OHNESORGE B M | 2004 | Radiology2004，23，1： | 1 |
| 6 | Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activation显示文摘 | Onno J de Boer Floris Hirsch Allard C van der Wal Chris M van der Loos Pranab K Das Anton E Becker | 1997 | Atherosclerosis1997，，2： | 1 |
| 7 | Minimum criteria for immediate provisionalization of single-tooth dental implants in extraction sites:a 1-year retrospective study of 100 consecutive cases显示文摘 | BECKER C M WILSON T J JENSEN O T | 2011 | J Oral Maxillofac Surg2011，69，2： | 1 |
| 8 | The universal character of the tumor associated antigen survivin 显示文摘 | Andersen M H Svane I M Becker J C | 2007 | Clin Cancer Res2007，13，20： | 1 |
| 9 | Dielectrophorephic segregation of different human cell types on microscope slides 显示文摘 | Das C M Becker F Vernon S | 2005 | Anal Chem2005，77，： | 1 |
| 10 | The effect of audit quality on earnings management 显示文摘 | Becker C M DeFond J Jiambalvo Subramanyam K R | 1998 | Contemporary Accounting Research1998，，15： | 1 |
| 11 | A framework for applying organizationalroutines in empirical research: Linking antecedents, char-acteristics and performance outcomes of recurrent interac-tion pattems显示文摘 | Becker M C | 2005 | Industrial and Corporate Change2005，14，5： | 1 |
| 12 | Cloning,sequencing,and characterization of a heat-and alkali-stable type Ⅰ pullulanase from Anaerobranca gottschalkii显示文摘 | Bertoldo C Armbrecht M Becker F Sch(a)fer T Antranikian G Liebl W | | 0，，06： | 1 |
| 13 | The phage K lyric enzyme LysK and lysostaphin act synergistically to kill MRSA显示文摘 | Becker S C Foster-Frey J Donovan D M | 2008 | Ferns Microhiol Lett2008，287，2： | 1 |
| 14 | Cervi-cal papillomavirus infection and cervical dysplasia inHispanic,Native American and non-hispanic whitewomen In New Mexico显示文摘 | Becker T M Wheeler C M Megough N S | 1991 | American Journal of Pub-lic Health1991，81，5： | 1 |
| 15 | I-dentification of a cytotoxic T lymphocyte response to the apoptosis inhibitor protein Survivin in cancer patients 显示文摘 | ANDERSEN M H PEDERSEN L O BECKER J C | 2001 | Cancer Res2001，61，3： | 1 |
| 16 | Human follicle- stimulating hormone beta -subunit gene encodes multiple messenger ribonucleic acids显示文摘 | Jameson J L Becker C B Lindell C M | 1958 | Mol Endocrinol1958，2，9： | 1 |
| 17 | Cloning,sequen- cing,and characterization of a heat-and alkali-stable type I pullulanase from Anaerobranca gottschalkii显示文摘 | Bertoldo C Armbrecht M Becker F | 2004 | Applied and Environmental Microbiology2004，70，6： | 1 |
| 18 | Organizational routine: A review of the literature显示文摘 | Becker M C | 2004 | Industrial and Corporate Change2004，13，4： | 1 |
| 19 | Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression 显示文摘 | Bopp T Becker C Klein M Klein-Hessling S Palmetshofer A Serfling E | 2007 | J Exp Med2007，204，6： | 1 |
| 20 | Targeted expression of human O6-methylguanine-DNA methyhransferase (MGMT) in transgenic mice protects against tumor initiation in two-stage skin carcinogenesis显示文摘 | PAZ M F GREGEL C M | 1996 | Cancer Res1996，56，14： | 1 |
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