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| 1 | 全球药物滥用的疾病负担:来自2010年全球疾病负担研究显示文摘背景:直到目前还没有研究者系统地估计过全球及区域性的苯丙胺类、大麻、可卡因和阿片类药物依赖的患病率及其造成的疾病负担。我们旨在用伤残损失寿命年(YLDs)、过早死亡损失寿命年(YLLs)和伤残调整寿命年(DALYs)来估计药物依赖的患病率和其造成的疾病负担。方法:采用贝叶斯Meta回归的方法(Dis Mod-MR)对药物依赖的流行病学研究及2010年全球疾病、伤害及危险因素负担研究(GBD 2010)进行了系统综述,估计人群水平的药物依赖患病率。GBD 2010通过代表性社区调查和基于互联网的调查计算出新的失能权重。我们把估计的药物依赖患病率和新的失能权重结合起来估算药物依赖导致的YLDs、YLLs、DALYs和其作为相关疾病危险因素时导致的YLDs、YLLs和DALYs。结果:2010年,药物依赖直接造成了2千万的DALYs(95%UI(不确定区间)1.3-2.54千万),占全球全因DALYs的0.8%(0.6%-1.0%)。世界范围内,相比于其他药物,越来越多的人依赖于阿片类和苯丙胺类药物。阿片类药物依赖直接造成的疾病负担最大(DALYs为920万,95%UI为710-1140万)。在某些地区,药物依赖导致的DALYs所占比例比其他地区高出20倍,收入越高的国家药物依赖造成的负担所占比例也越高。注射吸毒所致HIV感染造成210万的DALYs(95%UI 110-360万),所致HCV感染导致50.2万的DALYs(95%UI 28.6-89.1万)。苯丙胺类药物依赖所致自杀造成85.4万的DALYs(95%UI 29.1-179.1万),阿片类药物依赖所致自杀造成67.1万的DALYs(95%UI 32.9-173.0万),可卡因依赖所致自杀造成32.4万的DALYs(95%UI 10.9-68.2万)。药物依赖导致的疾病负担最高的国家(>650 DALYs/10万人)包括美国,英国,俄罗斯和澳大利亚。结论:药物滥用是造成全球疾病负担的一个重要因素。为减少人群水平的疾病负担,我们需采取有效的措施(比如给予阿片类药物依赖者替代治疗及针具交换等)降低阿片类药物依赖和注射吸毒导致的疾病负担。 | 王同瑜 Degenhardt L Whiteford HA Ferrari AJ Baxter AJ Charlson FJ Hall WD Freedman G Burstein R Johns Engell RE Flaxman A Murray CJ Vos T | 2015 | 中国药物依赖性杂志2015，24，6： | 3 |
| 2 | Critical size limit of biodegradable nanopartides for enhanced lymph node trafficking and paracortex penetration显示文摘Lymph node (LN) targeti ng through interstitial drain age of nan oparticles (NPs) is an attractive strategy to stimulate a pote nt immune respo nse, as LNs are the primary site for lymphocyte priming by antigen presenting cells (APCs) and triggering of an adaptive immune response. NP size has been shown to influence the efficiency of LN-targeting and retention after subcutaneous injection. For clinical translation, biodegradable NPs are preferred as carrier for vaccine delivery. However, the selective 'size gateM for effective LN-drainage, particularly the kinetics of LN trafficking, is less well defined. This is partly due to the challenge in generating size-controlled NPs from biodegradable polymers in the sub-100-nm range. Here, we report the preparation of three sets of poly(lactic-co-glycolic)-b-poly(ethylene-glycol)(PLGA-b-PEG) NPs with number average diameters of 20-, 40-, and 100-nm and narrow size distributions using flash nanoprecipitation. Using NPs labeled with a near-infrared dye, we showed that 20-nm NPs drain rapidly across proximal and distal LNs following subcutaneous inoculation in mice and are retai ned in LNs more effectively than NPs with a nu mber average diameter of 40-nm. The drain age of 100-nm NPs was n egligible. Furthermore, the 20-nm NPs showed the highest degree of penetration around the paracortex region and had enhanced access to dendritic cells in the LNs. Together, these data confirmed that small, size-controlled PLGA-b-PEG NPs at the lower threshold of about 30-nm are most effective for LN trafficking, retention, and APC uptake after s.c. administration. This report could inform the design of LN-targeted NP carrier for the delivery of therapeutic or prophylactic vaccines. | Gregory P. Howard Garima Verma Xiyu Ke Winter M. Thayer Timothy Hamerly Victoria K. Baxter John E. Lee Rhoel R. Dinglasan Hai-Quan Mao | 2019 | Nano Research2019，12，4： | 3 |
| 3 | 核安全关键软件的验证与确认技术(英文)显示文摘介绍了加拿大重水铀反应堆CANDU的安全关键软件的验证与确认(V&V)技术,说明了CANDU核反应堆停堆系统的脱扣计算机及其设计方法,详细描述了用于停堆脱扣计算机软件的确认和可靠性V&R测试的多功能测试平台,以及该测试平台在停堆脱扣计算机软件V&R测试中的应用。V&V技术已被成功地应用于各国CANDU核反应堆停堆系统的脱扣计算机设计中,如韩国的月城CANDU核反应堆、中国的秦山CANDU核反应堆、罗马尼亚Cernavda的2号CANDU核反应堆和加拿大Point Lepreau重建的CANDU核反应堆。随着计算机软硬件技术的发展,所描述的过程和工具在近期的项目中已得到了不断的改善。 | 赵敏达 Baxter John | 2011 | 自动化仪表2011，32，4： | 2 |
| 4 | THE NUCLEAR HORMONE RECEPTOR GENE SUPERFAMILY显示文摘 | Ralff C. J. Ribeiro M.D Peter J. Kushner Ph.D John D. Baxter M.D | 1995 | Annual Review of Medicine1995，，： | 1 |
| 5 | Macrophage Infection via Selective Capture of HIV-1-Infected CD4 + T Cells显示文摘 | Amy E. Baxter Rebecca A. Russell Christopher J.A. Duncan Michael D. Moore Christian B. Willberg Jose L. Pablos Andrés Finzi Daniel E. Kaufmann Christina Ochsenbauer John C. Kappes Fedde Groot Quentin J. Sattentau | 2014 | Cell Host & Microbe2014，，： | 1 |
| 6 | A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor显示文摘 | Grazia Chiellini James W. Apriletti Hikari Al Yoshihara John D. Baxter Ralff C.J. Ribeiro Thomas S. Scanlan | 1998 | Chemistry & Biology1998，，6： | 1 |
| 7 | Palladium gold removal recovery from precious metal solutions electronic scrap leachates by desulfovibrie Desulfuricans显示文摘 | Creamer N J Baxter Plant Victoria S Henderson John | 2006 | Biotechnology Letters2006，28，18： | 1 |
| 8 | 效率驱动着玻璃弯曲和钢化技术的发展显示文摘建筑和汽车玻璃的生产厂家正承受着在保持低成本的同时而继续提供高工程性能产品的日益增长的压力。本文追溯了19世纪70年代至今的热处理设备的发展趋势。 珍贵的高性能的玻璃产品正源源不断地进入市场,生产厂家正在为提供日益增长的能量效率和系统生产能力而激烈竞争,建筑玻璃也不例外。 在70年代早期,水平辊底钢化系统为钢化平板玻璃生产质量带来了一场革命。 | John S Baxter 王典芬 | 1999 | 国外建材科技1999，20，3： | 1 |
| 9 | From Sitting Principles to Sitting Practices:A Case Study of Discord among Trust,Equity and Community Participation显示文摘 | Jamie W Baxter John D Eyles Susan J Elliott | 1999 | Journal of Environmental planning and Management1999，42，4： | 1 |
| 10 | Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett’s oesophagus显示文摘 | Nihit Rawat Ali Alhamdani Elizabeth McAdam James Cronin Zak Eltahir Paul Lewis Paul Griffiths John N. Baxter Gareth J. S. Jenkins | 2012 | Clinical and Translational Oncology2012，，4： | 1 |
| 11 | Acidosis Augments Myogenic Constriction in Rat Coronary Arteries显示文摘 | Keith A. Baxter MD FRCSC Ismail Laher PhD John Church PhD York N. Hsiang MD FRCSC | 2006 | Annals of Vascular Surgery2006，，5： | 1 |
| 12 | Determination of Clinically Relevant Cutoffs for HIV-1 Phenotypic Resistance Estimates Through a Combined Analysis of Clinical Trial and Cohort Data显示文摘 | Bart Winters Julio Montaner P Richard Harrigan Brian Gazzard Anton Pozniak Michael D Miller Sean Emery Frank van Leth Patrick Robinson John D Baxter Marie Perez-Elias Delivette Castor Scott Hammer Alex Rinehart Hans Vermeiren Elke Van Craenenbroeck Lee Ba | 2008 | JAIDS Journal of Acquired Immune Deficiency Syndromes2008，，1： | 1 |
| 13 | A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long - Term Potentiation 显示文摘 | Paul Smolen Douglas A Baxter John H Byrne | 2006 | Biophysical Journal2006，90，15： | 1 |
| 14 | Prolonged administration of doxycycline in patients with small asymptomatic abdominal aortic aneurysms: Report of a prospective (Phase II) multicenter study显示文摘 | B.Timothy Baxter William H. Pearce Eugene A. Waltke Fred N. Littooy John W. Hallett K.Craig Kent Gilbert R. Upchurch Elliot L. Chaikof Joseph L. Mills Beverly Fleckten G.Matt Longo Jason K. Lee Robert W. Thompson | 2002 | Journal of Vascular Surgery2002，，1： | 1 |
| 15 | Cardiac resynchronization therapy in pacemaker-dependent patients with left ventricular dysfunction显示文摘 | John Gierula Richard M. Cubbon Haqeel A. Jamil Rowenna Byrom Paul D. Baxter Sue Pavitt Mark S. Gilthorpe Jenny Hewison Mark T. Kearney Klaus K.A. Witte | 2013 | Europace2013，，11： | 1 |
| 16 | Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor β subtype selective agonist KB-141显示文摘 | Galina Bryzgalova Suad Effendic Akhtar Khan Stefan Rehnmark Peter Barbounis Jamie Boulet Gao Dong Rajni Singh Sue Shapses Johan Malm Paul Webb John D. Baxter Gary J. Grover | 2008 | Journal of Steroid Biochemistry and Molecular Biology2008，，3： | 1 |
| 17 | Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor β subtype selective agonist KB-141显示文摘 | Galina Bryzgalova Suad Effendic Akhtar Khan Stefan Rehnmark Peter Barbounis Jamie Boulet Gao Dong Rajni Singh Sue Shapses Johan Malm Paul Webb John D. Baxter Gary J. Grover | 2008 | Journal of Steroid Biochemistry and Molecular Biology2008，，3： | 1 |
| 18 | Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight显示文摘 | John D. Baxter Paul Webb Gary Grover Tom S. Scanlan | 2004 | Trends in Endocrinology & Metabolism2004，，4： | 1 |
| 19 | A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor显示文摘 | Grazia Chiellini James W. Apriletti Hikari Al Yoshihara John D. Baxter Ralff C.J. Ribeiro Thomas S. Scanlan | 1998 | Chemistry & Biology1998，，6： | 1 |
| 20 | Complication Rates of Percutaneous Brachial Artery Access in Peripheral Vascular Angiography显示文摘 | Peter J. Armstrong David C. Han John A. Baxter James R. Elmore David P. Franklin | 2003 | Annals of Vascular Surgery2003，，1： | 1 |
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