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| 1 | Using strain energy-based prediction of effective elastic properties in topology optimization of material microstructures显示文摘一个其他的紧张精力方法在这篇论文为 orthotropic 材料的有效有弹性的性质的预言被建议。方法在拓扑学优化过程被实现设计细胞的固体。比较研究在紧张精力方法和著名 homogenization 方法之间被做。当同类的边界条件适当地被指定时,数字结果证明两个方法在数字预言和有效有弹性的张肌的敏感分析同意很好。二维并且三维的微观结构被把建议方法与凸的编程的双优化算法相结合为最大的僵硬图案优化。令人满意的结果为许多设计盒子被获得。 | Weihong Zhang Gaoming Dai Fengwen Wang Shiping Sun Hicham Bassir | 2007 | Acta Mechanica Sinica2007，23，1： | 15 |
| 2 | 蜂窝夹芯圆环的拓扑优化设计及尺度效应研究显示文摘采用尺度关联的一体化设计方法开展了旋转周期圆环结构的拓扑优化设计研究,以宏观结构的最大刚度为目标,研究了材料表征体胞尺度、构型以及不同载荷作用形式对蜂窝夹芯圆环结构优化结果的影响.所提出的无量纲结构构型因子实现了优化结构的结构效率量化评估.结合SIMP材料模型和周长控制方法,实现了宏观结构和细观表征体胞的优化设计,获得清晰的材料分布.数值算例表明,尺度关联的一体化设计方法能有效地完成圆环结构的拓扑优化设计,设计结果充分反映体胞尺度效应对旋转周期圆环结构夹芯构型的影响. | 孙士平 张卫红 邱克鹏 郭中泽 Bassir Hicham | 2007 | 力学学报2007，39，6： | 5 |
| 3 | Pancreatic cancer serum biomarker PC-594:Diagnostic performance and comparison to CA19-9显示文摘AIM:To investigate serum PC-594 fatty acid levels as a potential biomarker in North American pancreatic cancer(PaC) patients,and to compare its performance to CA19-9.METHODS:Using tandem mass spectrometry,we evaluated serum PC-594 levels from 84 North American patients with confirmed PaC and 99 cancer-free control subjects.We determined CA19-9 levels by ELISA.Significance between Pa C patients and controls,and association with clinical variables was determined by analysis of variance and t-tests.Diagnostic performance was evaluated by receiver-operator characteristic(ROC)curve analysis,and PC-594 correlation with age and CA19-9 determined by regression analysis.RESULTS:Mean PC-594 levels were 3.7 times lower in Pa C patients compared to controls(P < 0.0001).The mean level in PaC patient serum was 0.76 ± 0.07 μmol/L,and the mean level in control subjects was 2.79 ± 0.15 μmol/L.There was no correlation between PC-594 and age,disease stage or gender(P > 0.05).Using 1.25 μmol/L as a PC-594 threshold produced a relative risk(RR) of 9.4(P < 0.0001,95%CI:5.0-17.7).The area under the receiver-operator characteristic curve(ROCAUC) was 0.93(95%CI:0.91-0.95) for PC-594 and 0.85(95%CI:0.82-0.88) for CA19-9.Sensitivity at 90% specificity was 87% for PC-594 and 71% for CA19-9.Six Pa C patients with CA19-9 above 35 U/m L showed normal PC-594 levels,while 24 Pa C patients with normal CA19-9 showed low PC-594 levels.Eighty-five of the 99 control subjects(86%) showed normal levels of both markers.CONCLUSION:PC-594 biomarker levels are significantly reduced in North American Pa C patients,and showed superior diagnostic performance compared to CA19-9. | Shawn A Ritchie Bassirou Chitou Qingan Zheng Dushmanthi Jayasinghe Wei Jin Asuka Mochizuki Dayan B Goodenowe | 2015 | World Journal of Gastroenterology2015，21，21： | 3 |
| 4 | 内质网应激在大鼠心肌缺血再灌注损伤中的作用:与细胞自噬的关系显示文摘目的评价内质网应激在大鼠心肌缺血再灌注损伤中的作用及其与细胞自噬的关系。方法清洁级健康成年雄性SD大鼠36只,体重250~300 g,采用随机数字表法分为3组(n=12):假手术组(Sham组)、心肌缺血再灌注组(IR组)和内质网应激抑制剂4-PBA组(PBA组)。采用阻断冠状动脉左前降支(LAD)缺血30 min,再灌注120 min的方法制备大鼠心肌缺血再灌注损伤模型。Sham组仅行开胸处理但不阻断LAD;PBA组于造模前3 d连续灌胃给予内质网应激抑制剂4-PBA 500 mg·kg^(-1)·d^(-1),Sham组和IR组给予等量生理盐水。于再灌注120 min时采集髂静脉血样,采用ELISA法测定血浆CK-MB和cTnI浓度;随后处死大鼠取心肌组织,采用Western blot法检测心肌葡萄糖调节蛋白78(GRP78)、微管相关蛋白轻链3Ⅱ(LC3Ⅱ)和自噬相关蛋白5(ATG5)的表达。结果与Sham组比较,IR组和PBA组血浆CK-MB和cTnI浓度升高,IR组心肌组织GRP78、ATG5和LC3Ⅱ表达上调(P<0.05),病理学损伤加重;与IR组比较,PBA组血浆CK-MB和cTnI浓度降低,心肌组织GRP78、ATG5和LC3Ⅱ表达下调(P<0.05),病理学损伤减轻。结论内质网应激参与了大鼠心肌缺血再灌注损伤的过程,其机制可能与促进细胞自噬有关。 | 和凤 颜学滔 卢清 周慧敏 夏韵 Mohamed Bassirou MY 柯剑娟 王焱林 | 2021 | 中华麻醉学杂志2021，41，12： | 2 |
| 5 | A new pilot plant scale acetifier designed for vinegar production in Sub-Saharan Africa显示文摘 | Bassirou Ndoye Stephane Lebecque Jacqueline Destain | 2007 | Process Biochemis- try2007，，： | 1 |
| 6 | 显示文摘 | Huang L Bassir M Kaliaguine S | 2007 | Mater Chem Phys2007，101，： | 1 |
| 7 | Perovskitetype oxides synthesized by reacting grinding:Part 111 Kinetics of n-hexane oxidation over LaCo1-xFexO3显示文摘 | Szabo V Bassir M Van Neste A | | 0，，： | 1 |
| 8 | A review of the molecular approaches to investigate the diversity and activity of cheese microbiota显示文摘 | BASSIROU NDOYE ERIC ANDRIAMAHERY RASOLOFO GISELE LAPOINTE | 2011 | Dairy Sci & Technol2011，，91： | 1 |
| 9 | Raw milk composition of Malian Zebu cows(Bos indicus) raised under traditional system 显示文摘 | | 2005 | Journal of Food Composition and Analysis2005，，18： | 1 |
| 10 | Developments of Sizing Sensitivity Analysis with the ABAQUS Code 显示文摘 | Zhang W H Domaszewski M Bassir H | 1994 | Structural Optimization1994，，17： | 1 |
| 11 | Investigation of mastitis problems on farms显示文摘 | Ruegg P Bassirou B Jakob Z | 2003 | Vet Clin North Am:Food Anim Praet2003，19，1： | 1 |
| 12 | Problem-based learning in dental education : a systematic review of the literature 显示文摘 | Bassir SH Sadr-Eshkevari P Amirikhorheh S | 2014 | J Dent Educ2014，78，1： | 1 |
| 13 | Raw milk composition of Malian Zebu cows (Bos indicus)raised under traditional system显示文摘 | Bassirou B Jakob Z Zakaria F | 2005 | Journal of Food Composition and Analysis2005，18，： | 1 |
| 14 | Developments of sizing sensitivity analysis with ABAQUS code显示文摘 | Zhang WH Domaszewski M Bassir H | 1999 | International Journal of Structural Optimization1999，17，23： | 1 |
| 15 | Toxicological study of gamma-irradi- ated aflatoxins using the chicken embryo显示文摘 | Ogbadu G Bassir O | 1979 | Toxicology and applied pharmacology1979，51，2： | 1 |
| 16 | Perovskite -type oxides synthesized by reactive grinding: part Ⅱ: catalytic properties of LaCo(1 - x) Fe2O3 in VOC oxidation 显示文摘 | Szabo V Bassir M Van Neste A | 2002 | Applied Catalysis B : Environmental2002，37，2： | 1 |
| 17 | Effect of food stimulated liquids and thermocycling on the monomer elution from a nanofilled composite显示文摘 | Tabatabaei MH Sadrai S Bassir SH | 2013 | The Open Dentistry Journal2013，7，： | 1 |
| 18 | Temporal Changes in Root Growth and 15N Uptake and Water Relations of Two Tussock Grass Species Recovering Form Water Stress显示文摘 | BASSIR R H CALDWELL M M | 1992 | Physiol Plant1992，86，： | 1 |
| 19 | Reducibility of Co3+ in perovskite-type LaCoO3 and promotion of copper on the reduction of Co3+ in perovskite-type oxides显示文摘 | HUANG L BASSIR M KALIAGUINE S | 2005 | Applied Surface Science2005，243，2： | 1 |
| 20 | miRNA-146a在小鼠小胶质细胞炎症反应中的作用显示文摘目的评价microRNA(miR)-146a在小鼠小胶质细胞炎症反应中的作用。方法小鼠小胶质细胞BV2进行培养,选取对数生长期的细胞,采用随机数字表法分为5组(n=48):对照组(C组)、LPS组、LPS+miR-146a模拟物组(LPS-M组)、LPS+miR146-a抑制物组(LPS-I组)和LPS+阴性对照组(LPS-NC组)。LPS-M组、LPS-I组和LPS-NC组分别将miR-146-a模拟物RNA、miR-146a抑制物RNA和模拟物/抑制物的错义RNA转染至细胞。转染成功后,LPS组、LPS-M组、LPS-I组和LPS-NC组细胞分别加入终浓度为1μg/ml的LPS,C组加入等容量培养基,孵育6 h。采用qRT-PCR法检测细胞miR-146a、白介素受体相关激酶1(IRAK1)mRNA和肿瘤坏死因子受体相关因子6(TRAF6)mRNA的表达,采用Western blot法检测细胞IRAK1和TRAF6的表达。收集细胞上清液,采用ELISA法检测TNF-α、IL-1β和IL-6的浓度。结果与C组比较,LPS组细胞miR-146a表达、IRAK1和TRAF6及其mRNA及表达上调,上清液TNF-α、IL-1β和IL-6的浓度升高(P<0.05);与LPS组比较,LPS-M组细胞miR-146a表达上调,IRAK1和TRAF6及其mRNA表达下调,上清液TNF-α、IL-1β和IL-6的浓度降低,LPS-I组细胞miR-146a表达下调,IRAK1和TRAF6及其mRNA表达上调,上清液TNF-α、IL-1β和IL-6的浓度升高(P<0.05),LPS-NC组上述指标差异无统计学意义(P>0.05)。结论miR-146a是小鼠小胶质细胞炎症反应的内源性保护机制。 | 刘晨辉 Yacouba Mohamed Bassirou Moukeila 陈磊 董瑞 陆雅媛 周莹 彭勉 王焱林 | 2020 | 中华麻醉学杂志2020，40，12： | 1 |
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