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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Development of dual-responsive chitosan-collagen scaffolds for pulsatilerelease of bioactive molecules 显示文摘 | Barroso T Viveiros R Casimiro T | 2014 | J Supercrit Fluid2014，94，： | 1 |
| 3 | Perox-isome proliferator-aetivated receptor(PPAR)beta/delta:a new potential therapeutic target for the treatment of metabolic syn-drome显示文摘 | COLL T RODRIGUEZ-CALVO R BARROSO E | 2009 | Curr Mol Pharmacol2009，2，： | 1 |
| 4 | Biosensor based on multi-walled carbon nanotubes paste electrode modified with laccase for pirimicarb pesticide quantification显示文摘 | OLIVEIRA T M B F BARROSO M F MORAIS S | | 0，，： | 1 |
| 5 | The role of peroxisome proliferator- activated receptor beta/delta on the inflammatory basis of metabolic disease 显示文摘 | Coil T Barroso E Alvarez - Guardia D | 2006 | PPAR Res2006，18，1： | 1 |
| 6 | A green approach toward antibody purification:a sustainable biomimetic ligand for direct immobilization on (bio)polymeric supports显示文摘 | BARROSO T LOUREN O A ARA JO M | 2013 | Journal of Molecular Recognition2013，26，12： | 1 |
| 7 | Structural evaluation of an alternative protein A biomimetic ligand for antibody purification显示文摘 | BARROSO T BRANCO R J F AGUIAR-RICARDO A | 2014 | Journal of Computer-Aided Molecular Design2014，28，1： | 1 |
| 8 | Oxidative stability and sensory evaluation of micro- encapsulated flaxseed oil显示文摘 | BARROSO A K M PIERUCCI A P T R FREITAS S P | 2013 | J Microencapsul2013，31，2： | 1 |
| 9 | Effects of TGF-betal,PDGF-BB, and IGF-1 on the rate of proliferation and adhesion of a periodontal ligament cell lineage in vitro 显示文摘 | Sant A Marques M Barroso T | 2007 | J Periodontal2007，78，10： | 1 |
| 10 | Bioethanol and ethanol electro-oxidation by amorphous alloys with low amount of platinum显示文摘 | Barroso J Pierna A R Blanco T C | 2012 | International Journal of Hydrogen Energy2012，37，7： | 1 |
| 11 | Crack detection in asphaltic mixtures by computed tomography显示文摘 | BRAZ D BARROSO R C LOPES R T | 2011 | NI)T & E International2011，44，2： | 1 |
| 12 | Preparation and charac- terization of a cellulose affinity membrane for human immuno- globulin G (IgG) purification 显示文摘 | Barroso T Temtem M Hussain A | 2010 | Journal of Membrane Science2010，348，： | 1 |
| 13 | Composition of the essential oil from sepals of Leonotis leonurus R Br J Essent显示文摘 | PEDRO L G BARROSO J G MARQUES N T | 1991 | Journal of Essential Oil Research1991，3，： | 1 |
| 14 | X-ray diffraction tomography using interference effects显示文摘 | BARROSO R C LOPES R T GONCALVES O D | 1998 | Nuclear Instruments and Methods in Physics Research A1998，418，： | 1 |
| 15 | Development of pH-Responsive Poly (Methylmethacrylate-co-Methacrylic Acid) Membranes Using scCO2 Technology: Application to Protein Permeation 显示文摘 | Barroso T Temtern M Casimiro T | 2009 | J Supercrit Fluids2009，51，1： | 1 |
| 16 | Dinfimica de raizes de esp6cies arb6reas: Visfio da Literatura显示文摘 | De Freitas T A S Barroso D G Carneiro J G A | 2008 | Cincia Florestal2008，18，1： | 1 |
| 17 | Antifoulingperformance of poly (acrylonitrile) -based membranes :From green synthesis to application 显示文摘 | Barroso T Temtem M Casimiro T | 2011 | The Journal ofSupercritical Fluids2011，56，3： | 1 |
| 18 | 查看详情显示文摘 | Delgado M J S Barroso S R Fernandez-Tostado G T | | 0，，： | 1 |
| 19 | Visual processing disorders in patients with Huntington's disease and asymptomatic carriers显示文摘 | Gomez-Tortosa E del Barrio A Barroso T | 1996 | J Neurol1996，243，3： | 1 |
| 20 | Dominant negative muta tions in human PPARgamma associated with severe insulin re sistance,diabetes mellitus and hypertension显示文摘 | Gurnell M Crowley V E F Agostini M Schwabe J W Soos M A LI Maslen G Williams T D M Lewis H Schafer A J Chatterjee V K K O' Rahilly S | 1999 | Nature1999，402，： | 1 |
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