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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates 显示文摘 | Roman-Leshkov Y Barrett C J Liu Z Y Dumesic J A | 2007 | Nature2007，447，： | 1 |
| 3 | An exceptionally preserved Lower Cretaceous ecosystem显示文摘 | Zhou Z Barrett P M Hilton J | 2003 | Nature2003，421，： | 1 |
| 4 | 99mTc glucarate high-resolution imaging of drug sensitive and drug resistant human breast cancer xenografts in SCID mice显示文摘 | Liu Z Stevenson GD Barrett HH | 2004 | Nucl Med Commun2004，25，7： | 1 |
| 5 | Production of Dimethylfuran for Liquid Fuels from Biomass-derived Carbohydrates显示文摘 | ROMAN-LESHKOV Y BARRETT C J LIU Z Y | | 0，，： | 1 |
| 6 | Production of Dimethylfuran for Liquid Fuels from Biomass-derived Carbohydrates 显示文摘 | ROMAN-LESHKOV Y BARRETT C J LIU Z Y | 2007 | Nature2007，，447： | 1 |
| 7 | Disinhibition of neurotrophin-induced dorsal root ganglion cell neurite outgrowth on CNS myelin by siRNA-mediated knockdown of NgR, p75NTR and Rho-A显示文摘 | Ahmed Z Dent RG Suggate EL Barrett LB Seabfight R J Berry M | 2005 | Mol Cell Neurosci2005，28，3： | 1 |
| 8 | Geology,miner-alogy,and sulfur isotope geochemistry of the Sargaz Cu-Znvolcanogenic massive sulfide deposit,Sanandaj-Sirjan Zone,Iran显示文摘 | Badrzadeh Z Barrett T J Peter J M | 2011 | Mineralium Deposita2011，46，8： | 1 |
| 9 | Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates显示文摘 | Roman-Leshkov Y Barrett C J Liu Z Y | 2007 | Nature2007，447，： | 1 |
| 10 | Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates显示文摘 | Roman-Leshkov Y Barrett C J Liu Z Y | 2007 | Nature2007，447，7147： | 1 |
| 11 | High temperature ignition and combustion enhancement by dimethyl ether addition for liquid fuels from hiomas-derived carbohydrates显示文摘 | ROMAN-LESHKOV Y BARRETT C J LIU Z Y | 2007 | Nature2007，117，： | 1 |
| 12 | Wolly hair nevus with an ipsilateral associated epidermal nevus and additional findings of a white sponge nevus 显示文摘 | Allison L Traey T Barrett Z | 2010 | Pediatric Dermatol2010，27，1： | 1 |
| 13 | Anti-rhodopsin antibodies in sera from patients with normal-pressure glaucoma显示文摘 | Romano C Barrett DA Li Z | 1995 | Invest Ophthalmol Vis Sci1995，36，： | 1 |
| 14 | Production of dimethylfuran for liquid fuels from biomass-derived carbohydrates 显示文摘 | Roman-Leshkov Y Barrett C J Liu Z Y | 2007 | Nature2007，447，7147： | 1 |
| 15 | Dietary and other methyl group availabil ity factors and pancreatic cancer risk in a cohort of male smokers显示文摘 | Stolzenberg-Solomon R Z Pietinen P Barrett M J Taylor P R Virtamo J Albanes D | 2001 | Am J Epidemiol2001，153，： | 1 |
| 16 | High Temperature ignition and Combustion enhancement by Dimethyl Ether Addition for Liquid Fuels from Biomas-Derived Carbohydrates显示文摘 | Roman-Leshkov Y Barrett C J Liu Z Y | 2007 | Nature2007，，117： | 1 |
| 17 | Human protein metabolism:its measurement and regulation显示文摘 | Liu Z Barrett EJ | 2002 | Am J Physiol Endocrinol Metab2002，283，6： | 1 |
| 18 | Production of Dimethylfuran for Liquid Fuels from I3iomassderived Carbohydrates 显示文摘 | Roman--Leshkov Y Barrett C J Liu Z Y | 2007 | Nature2007，447，： | 1 |
| 19 | Production of dimethylfuran for liquid fuels from biomass-derived carbohy- drates 显示文摘 | Roman-Leshkov Y Barrett C J Liu Z Y | 2007 | Nature2007，447，7147： | 1 |
| 20 | Production of dimethylfuran for liquid fuels from biomass-derived car- bohydrates显示文摘 | ROMAN-LESHKOV Y BARRETT C J LIU Z Y | 2007 | Nature2007，447，7147： | 1 |
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