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| 1 | Pathophysiology and biology of peritoneal carcinomatosis显示文摘Peritoneal carcinomatosis represents a devastating form of cancer progression with a very poor prognosis.Its complex pathogenesis is represented by a dynamic process comprising several steps.To the best of our knowledge pathogenesis can be partly explained by 3 major molecular pathways: (1) dissemination from the primary tumor;(2) primary tumor of peritoneum;and (3) independent origins of the primary tumor and peritoneal implants.These are not mutually exclusive and combinations of different mechanisms could occur inside a single case.There are still several aspects which need explanation by future studies.A comprehensive understanding of molecular events involved in peritoneal carcinomatosis is of paramount importance and should be systematically pursued not only to identify novel strategies for the prevention of the condition,but also to obtain therapeutic advances,through the identification of surrogate markers of prognosis and development of future molecular targeted therapies. | Shigeki Kusamura Dario Baratti Nadia Zaffaroni Raffaella Villa Barbara Laterza Maria Rosaria Balestra Marcello Deraco | 2010 | World Journal of Gastrointestinal Oncology2010，2，1： | 8 |
| 2 | Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement显示文摘 | J. Esquivel R. Sticca P. Sugarbaker E. Levine T. D. Yan R. Alexander D. Baratti D. Bartlett R. Barone P. Barrios S. Bieligk P. Bretcha-Boix C. K. Chang F. Chu Q. Chu S. Daniel E. Bree M. Deraco L. Dominguez-Parra D. Elias R. Flynn J. Foster A. Garofalo F. | 2007 | Annals of Surgical Oncology2007，，1： | 4 |
| 3 | Early and long-term postoperative management following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy显示文摘Peritoneal surface malignancies have been traditionally regarded as end-stage conditions amenable to merely palliative options. The combination of aggressive cytoreductive surgery (CRS), involving peritonectomy procedures and multivisceral resections, with intra-operative hyperthermic intra-peritoneal chemotherapy (HIPEC) and/or early postoperative intra-peritoneal chemotherapy (EPIC) to treat the microscopic residual tumor is a new concept. In recent years, promising results have been reported for peritoneal mesothelioma and carcinomatosis of gastrointestinal and gynaecologic origin treated by this combined protocol. However, CRS with HIPEC and/or EPIC is a complex procedure associated with high rates of potentially life-threatening complications. Furthermore, disease progression following comprehensive treatment is not uncommon and represents a relevant cause of treatment failure. The present paper reviews the available information on early postoperative management and long-term follow-up in patients treated with CRS and intraperitoneal chemotherapy. The peculiar clinical and biological alterations that can be expected during an uncomplicated postoperative course, as compared to standard digestive surgery, are discussed. Early recognition and appropriate management of the most common adverse events are addressed, in order to minimize the impact of treatment-related morbidity on survival and quality of life results. Since re-operative surgery with additional HIPEC, has proven to be useful in selected patients with recurrent disease, long-term surveillance aiming at early detection of postoperative disease progression has become a relevant issue. Current results on follow-up investigations are presented. | Dario Baratti Shigeki Kusamura Barbara Laterza Maria Rosaria Balestra Marcello Deraco | 2010 | World Journal of Gastrointestinal Oncology2010，2，1： | 4 |
| 4 | Outcome of non-variceal acute upper gastrointestinal bleeding in relation to the time of endoscopy and the experience of the endoscopist: A two-year survey显示文摘AIM: To prospectively assess the impact of time of endoscopy and endoscopist's experience on the outcome of non-variceal acute upper gastrointestinal (GI) bleeding patients in a large teaching hospital.METHODS: All patients admitted for non-variceal acute upper GI bleeding for over a 2-year period were potentially eligible for this study. They were managed by a team of seven endoscopists on 24-h call whose experience was categorized into two levels (high and low) according to the number of endoscopic hemostatic procedures undertaken before the study. Endoscopic treatment was standardized according to Forrest classification of lesions as well as the subsequent medical therapy. Time of endoscopy was subdivided into two time periods: routine (8 a.m.-5 p.m.) and on-call (5 p.m.-8 a.m.). For each category of experience and time periods rebleeding rate, transfusion requirement, need for surgery, length of hospital stay and mortality we compared. Multivariate analysis was used to discriminate the impact of different variables on the outcomes that were considered.RESULTS: Study population consisted of 272 patients (mean age 67.3 years) with endoscopic stigmata of hemorrhage. The patients were equally distributed among the endoscopists, whereas only 19% of procedures were done out of working hours. Rockall score and Forrest classification at admission did not differ between time periods and degree of experience.Univariate analysis showed that higher endoscopist's experience was associated with significant reduction in rebleeding rate (14% vs 37%), transfusion requirements (1.8±0.6 vs 3.0±1.7 units) as well as surgery (4% vs 10%), but not associated with the length of hospital stay nor mortality. By contrast, outcomes did not significantly differ between the two time periods of endoscopy.On multivariate analysis, endoscopist's experience was independently associated with rebleeding rate and transfusion requirements. Odds ratios for low experienced endoscopist were 4.47 for rebleeding and 6.90 for need of transfusion after the endoscopy.CONCLUSION: Endoscopist's experience is an important independent prognostic factor for non-variceal acute upper GI bleeding. Urgent endoscopy should be undertaken preferentially by a skilled endoscopist as less expert staff tends to underestimate some risk lesions with a negative influence on hemostasis. | Fabrizio Parente Andrea Anderloni Stefano Bargiggia Venerina Imbesi Emilio Trabucchi Cinzia Baratti Silvano Gallus Gabriele Bianchi Porro | 2005 | World Journal of Gastroenterology2005，11，45： | 4 |
| 5 | Experience with peritoneal mesothelioma at the Milan National Cancer Institute显示文摘Diffuse malignant peritoneal mesothelioma (DMPM) is an uncommon and rapidly fatal tumor.Therapeutic options have traditionally been limited and ineffective.The biologic and molecular events correlated with poor responsiveness to therapy are still poorly understood.In recent years,an innovative treatment approach involving aggressive cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy has reportedly resulted in improved outcome,as compared to historical controls.Since 1995,at the National Cancer Institute (NCI) of Milan (Italy),patients with DMPM have been treated with CRS and hyperthermic intraperitoneal chemotherapy (HIPEC).In the present paper,clinical experiences and basic science investigations on DMPM at Milan NCI are reviewed.Perioperative and long-term outcome results with CRS and HIPEC are presented.Clinico-pathological prognostic factors were investigated by multivariate analysis.The pathologic features and immunohistochemical markers related to DMPM biologic behavior were assessed in a large case-series uniformly treated at our institution.The prevalence and prognostic role of telomere maintenance mechanisms,which account for the limitless cell replicative potential of many malignancies,were studied.The dysregulation of the apoptotic pathways may play a role in the relative chemo-resistance of DMPM and a better understanding of apoptosis-related mechanisms could result in novel targeted therapeutic strategies.On this basis,the expression of survivin and other IAP family members (IAP-1,IAP-2,and X-IAP),the pro-apoptotic protein Smac/DIABLO,and antigens associated with cell proliferation (Ki-67) and apoptosis (caspase-cleaved cytokeratin-18) were analyzed.Finally,analyses of EGFR,PDGFRA and PDGFRB were performed to ascertain if deregulation of RTK could offer useful alternative therapeutic targets. | Marcello Deraco Dario Baratti Antonello Domenico Cabras Nadia Zaffaroni Federica Perrone Raffaella Villa Jenny Jocollè Maria Rosaria Balestra Shigeki Kusamura Barbara Laterza Silvana Pilotti | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 3 |
| 6 | Diffuse Malignant Peritoneal Mesothelioma: Failure Analysis Following Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)显示文摘 | D. Baratti MD S. Kusamura MD PhD A. D. Cabras MD P. Dileo MD B. Laterza MD M. Deraco MD | 2009 | Annals of Surgical Oncology2009，，2： | 2 |
| 7 | Prognostic Analysis of Clinicopathologic Factors in 49 Patients With Diffuse Malignant Peritoneal Mesothelioma Treated With Cytoreductive Surgery and Intraperitoneal Hyperthermic Perfusion显示文摘 | Marcello Deraco MD Daisuke Nonaka MD Dario Baratti MD Paolo Casali MD Juan Rosai MD Rami Younan MD Andreola Salvatore MD Antonello D. Cabras AD MD Shigeki Kusamura MD | 2006 | Annals of Surgical Oncology2006，，2： | 2 |
| 8 | Peritonectomy and Intraperitoneal Hyperthermic Perfusion (IPHP): A Strategy That Has Confirmed its Efficacy in Patients with Pseudomyxoma Peritonei显示文摘 | Marcello Deraco Dario Baratti Maria Grazia Inglese Biagino Allaria Salvatore Andreola Cecilia Gavazzi Shigeki Kusamura | 2004 | Annals of Surgical Oncology2004，，： | 2 |
| 9 | Prognostic Value of Circulating Tumor Markers in Patients with Pseudomyxoma Peritonei Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy显示文摘 | Dario Baratti MD Shigeki Kusamura MD PhD Antonia Martinetti MD Ettore Seregni MD Barbara Laterza MD Daniela G. Oliva MD Marcello Deraco MD | 2007 | Annals of Surgical Oncology2007，，8： | 2 |
| 10 | Phlorizin,a competitive inhibitor of glucose transport,facilitates memory storage in mice显示文摘 | Boccia M KopfS Baratti C | 1999 | Neurobiol Learn Mem1999，71，： | 1 |
| 11 | Consensus Statement on the Loco Regional Treatment of Colorectal Cancer with Peritoneal Dissemination显示文摘 | Esquivel J Elias D Baratti D | 2008 | J Surg Oncol2008，98，4： | 1 |
| 12 | Pseudomyxoma peritonei : biologicalfeatures are the dominant prognostic determinants after complete cytoreduc- tion and hyperthermic intraperitoneal chemotherapy 显示文摘 | Baratti D Kusamura S Nonaka D | 2009 | Ann Surg2009，249，2： | 1 |
| 13 | Continuous production of ethanol with Zymomonas mobilis growing on Jerusalem artichoke juice 显示文摘 | ALLAIS J J TORRES E F BARATTI J | 1987 | Biotechnol Bioeng1987，29，6： | 1 |
| 14 | The impairment of retention induced by beta-endorphin in mice may be mediated by a reduction of central cholinergic activity显示文摘 | Baratti CM | 1984 | Behav Neural Biol1984，41，2： | 1 |
| 15 | Short chain flavor ester synthesis by a new esterase from Bacillus lichenifirmis 显示文摘 | Alvarez-Macarie E Baratti J | 2000 | Journal of Molecular Catalysis B: Enzymatic2000，10，4： | 1 |
| 16 | Purification,properties and comparison of invertase,exoinulinases and endoinulinases of Aspergillus ficuum显示文摘 | ETTALIBI M BARATTI J C | 1987 | Appl Microbiol Biotechnol1987，26，： | 1 |
| 17 | Impact of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy on Systemic Toxicity显示文摘 | Shigeki Kusamura MD PhD Dario Baratti MD Rami Younan MD Barbara Laterza MD Grazia Daniela Oliva MD Pasqualina Costanzo MD Myriam Favaro MD Cecilia Gavazzi MD Federica Grosso MD Marcello Deraco MD | 2007 | Annals of Surgical Oncology2007，，9： | 1 |
| 18 | Opioid peptidergic systems modulate the activity of beta-adrenergic mechanisms during memory consolidation processes显示文摘 | Baratti CM | 1986 | Behav Neural Biol1986，46，2： | 1 |
| 19 | Cytoreductive surgery followed by intraperitoneal hyperthemic perfusion:analysis of morbidity and mortality in 209 peritoneal surface malignancies treated with closed abdomen technique显示文摘 | Kusamura S Younan R Baratti D | 2006 | Cancer2006，106，5： | 1 |
| 20 | Lumped kinetic model for propene-butene mixtures oligomerization on a supported phosphoric acid catalyst显示文摘 | Giacomo Cao Antonio Viola Roberto Baratti | 1988 | Applied catalysis1988，41，： | 1 |
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